8HB5
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![BU of 8hb5 by Molmil](/molmil-images/mine/8hb5) | Crystal structure of Mincle in complex with HD-275 | 分子名称: | (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol, C-type lectin domain family 4 member E, CALCIUM ION | 著者 | Ishizuka, S, Nagae, M, Yamasaki, S. | 登録日 | 2022-10-27 | 公開日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand. Acs Cent.Sci., 9, 2023
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2YXO
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![BU of 2yxo by Molmil](/molmil-images/mine/2yxo) | Histidinol Phosphate Phosphatase complexed with Sulfate | 分子名称: | FE (III) ION, GLYCEROL, Histidinol phosphatase, ... | 著者 | Omi, R. | 登録日 | 2007-04-26 | 公開日 | 2007-11-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structure of Monofunctional Histidinol Phosphate Phosphatase from Thermus thermophilus HB8. Biochemistry, 46, 2007
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2YZ5
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8HSH
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![BU of 8hsh by Molmil](/molmil-images/mine/8hsh) | Thermus thermophilus RNA polymerase coreenzyme | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Murayama, Y, Ehara, H, Sekine, S. | 登録日 | 2022-12-19 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8HSG
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![BU of 8hsg by Molmil](/molmil-images/mine/8hsg) | Thermus thermophilus RNA polymerase elongation complex | 分子名称: | DNA (27-MER), DNA (37-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Murayama, Y, Ehara, H, Sekine, S. | 登録日 | 2022-12-19 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8HSL
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![BU of 8hsl by Molmil](/molmil-images/mine/8hsl) | Thermus thermophilus RNA polymerase bound with an inverted Rho hexamer | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ... | 著者 | Murayama, Y, Ehara, H, Sekine, S. | 登録日 | 2022-12-19 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8HSJ
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![BU of 8hsj by Molmil](/molmil-images/mine/8hsj) | Thermus thermophilus transcription termination factor Rho bound with ADP-BeF3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | 著者 | Murayama, Y, Ehara, H, Sekine, S. | 登録日 | 2022-12-19 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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8HSR
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![BU of 8hsr by Molmil](/molmil-images/mine/8hsr) | Thermus thermophilus Rho-engaged RNAP elongation complex (composite structure) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... | 著者 | Murayama, Y, Ehara, H, Sekine, S. | 登録日 | 2022-12-20 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
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6ANL
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![BU of 6anl by Molmil](/molmil-images/mine/6anl) | Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | 分子名称: | Mitogen-activated protein kinase 14, TAK-715 | 著者 | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | 登録日 | 2017-08-14 | 公開日 | 2018-01-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
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7EIC
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7EID
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7EIE
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![BU of 7eie by Molmil](/molmil-images/mine/7eie) | Crystal structure of YEATS2 YEATS domain | 分子名称: | GLYCEROL, YEATS domain-containing protein 2 | 著者 | Kikuchi, M, Umehara, T. | 登録日 | 2021-03-30 | 公開日 | 2022-04-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles. J.Biol.Chem., 298, 2022
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5ZFI
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![BU of 5zfi by Molmil](/molmil-images/mine/5zfi) | Mouse kallikrein 7 in complex with 6-benzyl-1,4-diazepan-7-one derivative | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[(3Z,6R)-6-[(2,6-dichlorophenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxo-1,4-diazepan-1-yl]-N-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]acetamide, Kallikrein-7 | 著者 | Sugawara, H. | 登録日 | 2018-03-06 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones. Bioorg. Med. Chem., 26, 2018
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5ZFH
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![BU of 5zfh by Molmil](/molmil-images/mine/5zfh) | Mouse Kallikrein 7 | 分子名称: | Kallikrein-7 | 著者 | Sugawara, H. | 登録日 | 2018-03-06 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones. Bioorg. Med. Chem., 26, 2018
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7CSS
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![BU of 7css by Molmil](/molmil-images/mine/7css) | |
7D37
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7Y1G
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![BU of 7y1g by Molmil](/molmil-images/mine/7y1g) | Crystal structure of human PRKACA complexed with DS01080522 | 分子名称: | 1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide, ZINC ION, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Suzuki, M, Ubukata, O, Toyoda, A. | 登録日 | 2022-06-08 | 公開日 | 2022-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model. Biochem.Biophys.Res.Commun., 621, 2022
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5X9O
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![BU of 5x9o by Molmil](/molmil-images/mine/5x9o) | Crystal structure of the BCL6 BTB domain in complex with Compound 1a | 分子名称: | 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | 登録日 | 2017-03-08 | 公開日 | 2017-08-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
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5X9P
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![BU of 5x9p by Molmil](/molmil-images/mine/5x9p) | Crystal structure of the BCL6 BTB domain in complex with Compound 5 | 分子名称: | 3-[[4-chloranyl-2-nitro-5-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]phenyl]amino]propanoic acid, B-cell lymphoma 6 protein | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | 登録日 | 2017-03-08 | 公開日 | 2017-08-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
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6IYQ
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8I1C
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8I1A
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8I1I
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![BU of 8i1i by Molmil](/molmil-images/mine/8i1i) | Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP at pH 7.7 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Yamagata, Y. | 登録日 | 2023-01-13 | 公開日 | 2023-03-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. Febs Lett., 597, 2023
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8I1D
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![BU of 8i1d by Molmil](/molmil-images/mine/8i1d) | Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 7.7 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Yamagata, Y. | 登録日 | 2023-01-13 | 公開日 | 2023-03-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. Febs Lett., 597, 2023
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8I1E
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![BU of 8i1e by Molmil](/molmil-images/mine/8i1e) | Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 8.0 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Yamagata, Y. | 登録日 | 2023-01-13 | 公開日 | 2023-03-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. Febs Lett., 597, 2023
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