3C4E
 
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3C4F
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7YLM
 | | Cryo-EM structure of 8-subunit Smc5/6 hinge region | | 分子名称: | MMS21 isoform 1, SMC6 isoform 1, Structural maintenance of chromosomes protein 5 | | 著者 | Qian, L, Jun, Z, Xiang, Z, Wang, Z, Tong, C, Duo, J, Zhenguo, C, Wang, L. | | 登録日 | 2022-07-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (6.17 Å) | | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms.
Nat.Struct.Mol.Biol., 2024
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3V43
 | | Crystal structure of MOZ | | 分子名称: | ACETATE ION, Histone H3.1, Histone acetyltransferase KAT6A, ... | | 著者 | Qiu, Y, Li, F. | | 登録日 | 2011-12-14 | | 公開日 | 2012-06-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription
Genes Dev., 26, 2012
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8IFF
 | | Cryo-EM structure of Arabidopsis phytochrome A. | | 分子名称: | 3-[5-[[(3~{R},4~{R})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, Phytochrome A | | 著者 | Ma, L, Zhou, C, Wang, J, Guan, Z, Yin, P. | | 登録日 | 2023-02-17 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Plant phytochrome A in the Pr state assembles as an asymmetric dimer.
Cell Res., 33, 2023
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8XZQ
 | | Crystal structure of folE riboswitch with 8-N Guanine | | 分子名称: | 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL, MAGNESIUM ION, RNA (53-MER), ... | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZL
 | | Crystal structure of folE riboswitch with DHF | | 分子名称: | DIHYDROFOLIC ACID, MAGNESIUM ION, RNA (53-MER), ... | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZW
 | | Crystal structure of THF-II riboswitch with THF and soaked with Ir | | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, MAGNESIUM ION, RNA (53-MER), ... | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZN
 | | Crystal structure of folE riboswitch with BH4 | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, MAGNESIUM ION, RNA (53-MER), ... | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZE
 | | Crystal structure of THF-II riboswitch with THF and soaked with Ir | | 分子名称: | (6S)-5,6,7,8-TETRAHYDROFOLATE, IRIDIUM ION, MAGNESIUM ION, ... | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZR
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8XZM
 | | Crystal structure of folE riboswitch with DHN | | 分子名称: | 2-AMINO-7,8-DIHYDRO-6-(1,2,3-TRIHYDROXYPROPYL)-4(1H)-PTERIDINONE, MAGNESIUM ION, RNA (53-MER), ... | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZO
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8XZK
 | | Crystal structure of folE riboswitch | | 分子名称: | RNA (53-MER) | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8XZP
 | | Crystal structure of folE riboswitch with 8-CH3 Guanine | | 分子名称: | 2-azanyl-8-methyl-1,9-dihydropurin-6-one, MAGNESIUM ION, RNA (53-MER), ... | | 著者 | Li, C.Y, Ren, A.M. | | 登録日 | 2024-01-21 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structure-based characterization and compound identification of the wild-type THF class-II riboswitch.
Nucleic Acids Res., 52, 2024
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8TXG
 | | Crystal structure of KRAS G12D in complex with GDP and compound 8 | | 分子名称: | (4M)-4-(6-chloro-4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}quinazolin-7-yl)-7-fluoro-1,3-benzothiazol-2-amine, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Chen, P, Irimia, A, Yang, Z. | | 登録日 | 2023-08-23 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8TXH
 | | Crystal structure of KRAS G12D in complex with GDP and compound 14 | | 分子名称: | (4P)-2-amino-4-{4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}-6-(trifluoromethyl)quinazolin-7-yl}-7-fluoro-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Chen, P, Irimia, A, Yang, Z. | | 登録日 | 2023-08-23 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8TXE
 | | Crystal structure of KRAS G12D in complex with GDP and compound 5 | | 分子名称: | (6M)-6-(6-chloro-4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}quinazolin-7-yl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Chen, P, Irimia, A, Yang, Z. | | 登録日 | 2023-08-23 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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5DRY
 | | Crystal structure of Dot1L in complex with inhibitor CPD3 [N-(1-(2-chlorophenyl)-1H-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1H-tetrazol-1-yl)acetyl)hydrazinecarboxamide] | | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, N-[1-(2-chlorophenyl)-1H-indol-6-yl]-2-{[5-(2-chlorophenyl)-1H-tetrazol-1-yl]acetyl}hydrazinecarboxamide, ... | | 著者 | Scheufler, C, Gaul, C, Be, C, Moebitz, H. | | 登録日 | 2015-09-16 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach.
Acs Med.Chem.Lett., 7, 2016
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8Z9Z
 | | Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Odorant receptor, ApisOR5, ... | | 著者 | Wang, Y.D, Qiu, L, Guan, Z.Y, Wang, Q, Wang, G.R, Yin, P. | | 登録日 | 2024-04-24 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex.
Science, 384, 2024
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8Z9A
 | | Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum bound with geranyl acetate | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Odorant receptor, ApisOR5, ... | | 著者 | Wang, Y.D, Qiu, L, Guan, Z.Y, Wang, Q, Wang, G.R, Yin, P. | | 登録日 | 2024-04-23 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex.
Science, 384, 2024
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8JHZ
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8JI0
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5EEH
 | | Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with SAH and 2-chloro-4-nitrophenol | | 分子名称: | 2-chloranyl-4-nitro-phenol, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Wang, F, Singh, S, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2015-10-22 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.
Acs Chem.Biol., 11, 2016
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6LS2
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