3C4F

FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole

Summary for 3C4F

Related3C4C 3C4D 3C4E
DescriptorBasic fibroblast growth factor receptor 1, 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (3 entities in total)
Functional Keywordsfibroblast growth factor receptor, tyrosine kinase domain, receptor tyrosine kinase, fgfr1, fgfr, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, dwarfism, glycoprotein, heparin-binding, immunoglobulin domain, kallmann syndrome, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P11362
Total number of polymer chains2
Total molecular weight69452.03
Authors
Zhang, K.Y.J.,Wang, W. (deposition date: 2008-01-29, release date: 2008-02-26, Last modification date: 2011-07-13)
Primary citation
Tsai, J.,Lee, J.T.,Wang, W.,Zhang, J.,Cho, H.,Mamo, S.,Bremer, R.,Gillette, S.,Kong, J.,Haass, N.K.,Sproesser, K.,Li, L.,Smalley, K.S.,Fong, D.,Zhu, Y.L.,Marimuthu, A.,Nguyen, H.,Lam, B.,Liu, J.,Cheung, I.,Rice, J.,Suzuki, Y.,Luu, C.,Settachatgul, C.,Shellooe, R.,Cantwell, J.,Kim, S.H.,Schlessinger, J.,Zhang, K.Y.,West, B.L.,Powell, B.,Habets, G.,Zhang, C.,Ibrahim, P.N.,Hirth, P.,Artis, D.R.,Herlyn, M.,Bollag, G.
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105:3041-3046, 2008
PubMed: 18287029 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0711741105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.07 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers30.9%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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