3C4F
FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Basic fibroblast growth factor receptor 1 | polymer | 302 | 34487.7 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | FGFR-1, bFGF-R, Fms-like tyrosine kinase 2, c-fgr, CD331 antigen |
| 2 | C, D (A, B) | 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine | non-polymer | 238.3 | 2 | Chemie (C4F) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 356 | Chemie (HOH) |
Sequence modifications
A, B: 464 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Ala 488 | Cys 488 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68975.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 476.6 | |
| All* | Total formula weight | 69452.0 |
