5GTM
 
 | | Modified human MxA, nucleotide-free form | | 分子名称: | Interferon-induced GTP-binding protein Mx1 | | 著者 | Chen, Y, Gao, S. | | 登録日 | 2016-08-22 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.896 Å) | | 主引用文献 | Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
Nat Commun, 8, 2017
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4WCM
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8W41
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4M49
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8VJK
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8VK3
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8TU3
 | | Bruton's tyrosine kinase in complex with covalent inhibitor compound 10 | | 分子名称: | 1-[(4R)-4-{[(6P,8S)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one, Tyrosine-protein kinase BTK | | 著者 | Metrick, C.M. | | 登録日 | 2023-08-15 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J.Med.Chem., 67, 2024
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8TU5
 | | Bruton's tyrosine kinase in complex with covalent inhibitor compound 27 | | 分子名称: | 1-[(1S,5S,6S)-6-methyl-6-{[(6M,8R)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one, Tyrosine-protein kinase BTK | | 著者 | Metrick, C.M. | | 登録日 | 2023-08-15 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J.Med.Chem., 67, 2024
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4WCL
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8TU4
 | | Bruton's tyrosine kinase in complex with covalent inhibitor compound 25 | | 分子名称: | N-methyl-N-[(1S,3r)-3-methyl-3-{[(6M,8S)-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide, Tyrosine-protein kinase BTK | | 著者 | Metrick, C.M. | | 登録日 | 2023-08-15 | | 公開日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J.Med.Chem., 67, 2024
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8VJJ
 | | Structure of mouse RyR1 (EGTA-only dataset) | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ... | | 著者 | Weninger, G, Marks, A.R. | | 登録日 | 2024-01-07 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structural insights into the regulation of RyR1 by S100A1.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8VK4
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4WCN
 | | Crystal Structure of Tripeptide bound Cell Shape Determinant Csd4 protein from Helicobacter pylori | | 分子名称: | Conserved hypothetical secreted protein, IODIDE ION, N-acetyl-L-alanyl-N-[(1S,5R)-5-amino-1,5-dicarboxypentyl]-D-glutamine, ... | | 著者 | Chan, A.C, Murphy, M.E. | | 登録日 | 2014-09-05 | | 公開日 | 2014-12-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Helical Shape of Helicobacter pylori Requires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4.
J.Biol.Chem., 290, 2015
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4WBH
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5HBA
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4WCK
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5HBZ
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4EQ6
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7COM
 | | Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121) | | 分子名称: | 3C-like proteinase, boceprevir (bound form) | | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J. | | 登録日 | 2020-08-04 | | 公開日 | 2020-08-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
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7F6G
 | | Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin receptor AT1R, CHOLESTEROL, ... | | 著者 | Zhang, D, Xu, L, Zhan, Y, Guo, J, Zhang, H. | | 登録日 | 2021-06-25 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.
Embo J., 42, 2023
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5I9H
 | | Crystal structure of designed pentatricopeptide repeat protein dPPR-U8G2 in complex with its target RNA U8G2 | | 分子名称: | RNA (5'-R(*GP*GP*GP*GP*UP*UP*UP*UP*GP*GP*UP*UP*UP*UP*CP*CP*CP*C)-3'), pentatricopeptide repeat protein dPPR-U8G2 | | 著者 | Shen, C, Zhang, D, Guan, Z, Zou, T, Yin, P. | | 登録日 | 2016-02-20 | | 公開日 | 2016-04-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | | 主引用文献 | Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins.
Nat Commun, 7, 2016
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4O0Z
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5I9G
 | | Crystal structure of designed pentatricopeptide repeat protein dPPR-U8C2 in complex with its target RNA U8C2 | | 分子名称: | RNA (5'-R(*GP*GP*G*GP*UP*UP*UP*UP*CP*CP*UP*UP*UP*UP*CP*CP*CP*C)-3'), pentatricopeptide repeat protein dPPR-U8C2 | | 著者 | Shen, C, Zhang, D, Guan, Z, Zou, T, Yin, P. | | 登録日 | 2016-02-20 | | 公開日 | 2016-04-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | | 主引用文献 | Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins.
Nat Commun, 7, 2016
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6KUR
 | | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B1) | | 分子名称: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 4, 2019
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6KUK
 | | Structure of influenza D virus polymerase bound to vRNA promoter in mode A conformation (class A1) | | 分子名称: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 4, 2019
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