4WBH
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I APO - 2.2A
Summary for 4WBH
Entry DOI | 10.2210/pdb4wbh/pdb |
Descriptor | Protein notum homolog, CHLORIDE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | wnt, extracellular esterase, alpha/beta hydrolase, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : Q6P988 |
Total number of polymer chains | 2 |
Total formula weight | 106656.87 |
Authors | Zebisch, M.,Jones, E.Y. (deposition date: 2014-09-03, release date: 2015-02-25, Last modification date: 2020-07-29) |
Primary citation | Kakugawa, S.,Langton, P.F.,Zebisch, M.,Howell, S.A.,Chang, T.-H.,Liu, Y.,Feizi, T.,Bineva, G.,O'Reilly, N.,Snijders, A.P.,Jones, E.Y.,Vincent, J.-P. Notum deacylates Wnt proteins to suppress signalling activity Nature, 519:187-192, 2015 Cited by PubMed: 25731175DOI: 10.1038/nature14259 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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