4WBH
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I APO - 2.2A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004629 | molecular_function | phospholipase C activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016298 | molecular_function | lipase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| A | 0030500 | biological_process | regulation of bone mineralization |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0060348 | biological_process | bone development |
| A | 0090090 | biological_process | negative regulation of canonical Wnt signaling pathway |
| A | 0140776 | molecular_function | protein-containing complex destabilizing activity |
| A | 1990697 | biological_process | protein depalmitoleylation |
| A | 1990699 | molecular_function | palmitoleyl hydrolase activity |
| B | 0004629 | molecular_function | phospholipase C activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0016298 | molecular_function | lipase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| B | 0030500 | biological_process | regulation of bone mineralization |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0060348 | biological_process | bone development |
| B | 0090090 | biological_process | negative regulation of canonical Wnt signaling pathway |
| B | 0140776 | molecular_function | protein-containing complex destabilizing activity |
| B | 1990697 | biological_process | protein depalmitoleylation |
| B | 1990699 | molecular_function | palmitoleyl hydrolase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"25731175","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PDB","id":"4UYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UYW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
