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4G3C
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BU of 4g3c by Molmil
Crystal structure of apo murine Nf-kappaB inducing kinase (NIK)
分子名称: NF-kappa-beta-inducing kinase, SULFATE ION
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
7VM1
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BU of 7vm1 by Molmil
Crystal Structure of HasAp Capturing Iron Tetra(4-pyridyl)porphyrin
分子名称: Fe-Tetra(4-pyridyl)porphyrin, GLYCEROL, Heme acquisition protein HasAp
著者Shisaka, Y, Ueda, G, Sakakibara, E, Sugimoto, H, Shoji, O.
登録日2021-10-06
公開日2022-08-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.
Chembiochem, 23, 2022
6DGF
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BU of 6dgf by Molmil
Ubiquitin Variant bound to USP2
分子名称: Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 2, ...
著者Manczyk, N, Sicheri, F.
登録日2018-05-17
公開日2019-02-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.
J. Mol. Biol., 431, 2019
2I4Z
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BU of 2i4z by Molmil
Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours.
分子名称: (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID, Peroxisome proliferator-activated receptor gamma
著者Pochetti, G, Mazza, F.
登録日2006-08-23
公開日2007-04-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands
J.Biol.Chem., 282, 2007
2I4P
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BU of 2i4p by Molmil
Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). Structure obtained from crystals of the apo-form soaked for 30 days.
分子名称: (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID, Peroxisome proliferator-activated receptor gamma
著者Pochetti, G, Mazza, F.
登録日2006-08-22
公開日2007-04-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
J.Biol.Chem., 282, 2007
4I4E
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BU of 4i4e by Molmil
Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound.
分子名称: Focal adhesion kinase 1, [4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone
著者Skene, R.J, Hosfield, D.J.
登録日2012-11-27
公開日2013-03-06
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structure-based discovery of cellular-active allosteric inhibitors of FAK.
Bioorg.Med.Chem.Lett., 23, 2013
1DJG
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BU of 1djg by Molmil
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH LANTHANUM
分子名称: ACETATE ION, LANTHANUM (III) ION, PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ...
著者Essen, L.-O, Perisic, O, Williams, R.L.
登録日1996-09-25
公開日1997-07-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
Biochemistry, 36, 1997
4G3F
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BU of 4g3f by Molmil
Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)
分子名称: 3-{2-[(5-fluoro-2-hydroxyphenyl)amino]-1,3-thiazol-4-yl}benzonitrile, NF-kappa-beta-inducing kinase
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.642 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
1DJH
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BU of 1djh by Molmil
PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH BARIUM
分子名称: ACETATE ION, BARIUM ION, PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ...
著者Essen, L.-O, Perisic, O, Williams, R.L.
登録日1996-09-25
公開日1997-07-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
Biochemistry, 36, 1997
2QNB
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BU of 2qnb by Molmil
Glycogen Phosphorylase b in complex with N-benzoyl-N'-beta-D-glucopyranosyl urea
分子名称: Glycogen phosphorylase, muscle form, N-[(phenylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine
著者Chrysina, E.D, Tiraidis, C, Alexacou, K.-M, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G.
登録日2007-07-18
公開日2008-07-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published
2QLM
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BU of 2qlm by Molmil
Glycogen phosphorylase in complex with FN67
分子名称: Glycogen phosphorylase, muscle form, N-{[(4-methylphenyl)carbonyl]carbamoyl}-beta-D-glucopyranosylamine
著者Oikonomakos, N.G, Chryina, E.D, Tiraidis, C, Kosmopoulou, M.N, Zographos, S.E, Leonidas, D.D.
登録日2007-07-13
公開日2008-07-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published
2QN7
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BU of 2qn7 by Molmil
Glycogen Phosphorylase b in complex with N-4-hydroxybenzoyl-N'-4-beta-D-glucopyranosyl urea
分子名称: Glycogen phosphorylase, muscle form, INOSINIC ACID, ...
著者Chrysina, E.D, Tiraidis, K, Alexacou, K.-M, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G.
登録日2007-07-18
公開日2008-07-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published
2QN3
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BU of 2qn3 by Molmil
Glycogen Phosphorylase in complex with N-4-chlorobenzoyl-N-beta-D-glucopyranosyl urea
分子名称: Glycogen phosphorylase, muscle form, N-{[(4-chlorophenyl)carbonyl]carbamoyl}-beta-D-glucopyranosylamine
著者Chrysina, E.D, Tiraidis, C, Alexacou, K.-M, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G.
登録日2007-07-17
公開日2008-07-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published
2QLN
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BU of 2qln by Molmil
Glycogen Phosphorylase b in complex with N-4-phenylbenzoyl-N'-beta-D-glucopyranosyl urea
分子名称: Glycogen phosphorylase, muscle form, N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine
著者Oikonomakos, N.G, Chrysina, E.D, Tiraidis, C, Alexacou, K.-M, Leonidas, D.D, Sographos, S.E.
登録日2007-07-13
公開日2008-07-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published
6HUD
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BU of 6hud by Molmil
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient.
分子名称: Monoclonal immunoglobulin light chains (LC)
著者Paissoni, C, Camilloni, C.
登録日2018-10-06
公開日2019-03-27
最終更新日2019-04-03
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient.
Nat Commun, 10, 2019
4OBQ
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BU of 4obq by Molmil
MAP4K4 in complex with inhibitor (compound 31), N-[3-(4-AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, Mitogen-activated protein kinase kinase kinase kinase 4, ...
著者Harris, S.F, Wu, P, Coons, M.
登録日2014-01-07
公開日2014-04-23
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization.
J.Med.Chem., 57, 2014
2E7A
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BU of 2e7a by Molmil
TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
分子名称: Tumor necrosis factor
著者Mukai, Y, Yamagata, Y, Tsutsumi, Y.
登録日2007-01-09
公開日2007-11-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
J.Biol.Chem., 283, 2008
2DOK
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BU of 2dok by Molmil
Crystal structure of the PIN domain of human EST1A
分子名称: Telomerase-binding protein EST1A
著者Takeshita, D.
登録日2006-05-01
公開日2007-05-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the PIN domain of human telomerase-associated protein EST1A
Proteins, 68, 2007
2QN8
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BU of 2qn8 by Molmil
Glycogen Phosphorylase b in complex with N-4-nitrobenzoyl-N'-beta-D-glucopyranosyl urea
分子名称: Glycogen phosphorylase, muscle form, N-{[(4-nitrophenyl)carbonyl]carbamoyl}-beta-D-glucopyranosylamine, ...
著者Chrysina, E.D, Tiraidis, C, Alexacou, K.-M, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G.
登録日2007-07-18
公開日2008-07-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published
1IXU
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BU of 1ixu by Molmil
Solution structure of marinostatin, a protease inhibitor, containing two ester linkages
分子名称: marinostatin
著者Kanaori, K, Kamei, K, Koyama, T, Yasui, T, Takano, R, Imada, C, Tajima, K, Hara, S.
登録日2002-07-04
公開日2004-02-17
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Solution structure of marinostatin, a natural ester-linked protein protease inhibitor
Biochemistry, 44, 2005
6JQ9
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BU of 6jq9 by Molmil
Crystal structure of a lyase from Alteromonas sp.
分子名称: CALCIUM ION, SULFATE ION, Short ulvan lyase
著者Qin, H.M, Guo, Q.Q.
登録日2019-03-29
公開日2020-04-01
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Biochemical characterization and structural analysis of ulvan lyase from marine Alteromonas sp. reveals the basis for its salt tolerance.
Int.J.Biol.Macromol., 147, 2020
3WVS
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BU of 3wvs by Molmil
Crystal Structure of Cytochrome P450revI
分子名称: (2E,4S,5S,6E,8E)-10-{(2R,3S,6S,8R,9S)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl}-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid, GLYCEROL, L(+)-TARTARIC ACID, ...
著者Nagano, S, Takahashi, S, Osada, H, Shiro, Y.
登録日2014-06-06
公開日2014-10-01
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T.
J.Biol.Chem., 289, 2014
2W2W
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BU of 2w2w by Molmil
PLCg2 Split Pleckstrin Homology (PH) Domain
分子名称: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2W2T
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BU of 2w2t by Molmil
Rac2 (G12V) in complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2W2V
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Rac2 (G12V) in complex with GTPgS
分子名称: GUANOSINE-5'-TRIPHOSPHATE, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009

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