2QLN

Glycogen Phosphorylase b in complex with N-4-phenylbenzoyl-N'-beta-D-glucopyranosyl urea

Summary for 2QLN

Related2QLM 2QN3 2QN7 2QN8 2QN9 2QNB
DescriptorGlycogen phosphorylase, muscle form, N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine (3 entities in total)
Functional Keywordsglycogenolysis, type 2 diabetes, acetylation, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase
Biological sourceOryctolagus cuniculus (Rabbit)
Total number of polymer chains1
Total molecular weight97921.72
Authors
Oikonomakos, N.G.,Chrysina, E.D.,Tiraidis, C.,Alexacou, K.-M.,Leonidas, D.D.,Sographos, S.E. (deposition date: 2007-07-13, release date: 2008-07-15, Last modification date: 2011-07-13)
Primary citation
Nagy, V.,Felf ldi, N.,Praly, J.-P.,Dosca, T.,Gergerly, P.,Chrysina, E.D.,Tiraidis, C.,Kosmopoulou, M.N.,Alexacou, K.-M.,Konstantakaki, M.
N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation
To be Published,
Experimental method
X-RAY DIFFRACTION (2.15 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers104.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution