3H8B
 
 | | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 9) | | 分子名称: | Cathepsin L1, N~2~,N~6~-bis(biphenyl-4-ylacetyl)-L-lysyl-D-arginyl-N-(2-phenylethyl)-L-phenylalaninamide | | 著者 | Tulsidas, S.R, Chowdhury, S.F, Kumar, S, Joseph, L, Purisima, E.O, Sivaraman, J. | | 登録日 | 2009-04-29 | | 公開日 | 2009-10-20 | | 最終更新日 | 2014-02-05 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J.Med.Chem., 52, 2009
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3H89
 | | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 4) | | 分子名称: | Cathepsin L1, N~2~,N~6~-bis(biphenyl-4-ylacetyl)-L-lysyl-D-arginyl-N-(2-phenylethyl)-L-tyrosinamide | | 著者 | Tulsidas, S.R, Chowdhury, S.F, Kumar, S, Joseph, L, Purisima, E.O, Sivaraman, J. | | 登録日 | 2009-04-29 | | 公開日 | 2009-10-20 | | 最終更新日 | 2014-02-05 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J.Med.Chem., 52, 2009
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3H8C
 | | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors (compound 14) | | 分子名称: | Cathepsin L1, N-(biphenyl-4-ylacetyl)-S-methyl-L-cysteinyl-D-arginyl-N-(2-phenylethyl)-L-phenylalaninamide | | 著者 | Tulsidas, S.R, Chowdhury, S.F, Kumar, S, Joseph, L, Purisima, E.O, Sivaraman, J. | | 登録日 | 2009-04-29 | | 公開日 | 2009-10-20 | | 最終更新日 | 2014-11-12 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Combined Crystallographic and Molecular Dynamics Study of Cathepsin L Retrobinding Inhibitors
J.Med.Chem., 2009
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3HH7
 | | Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra) | | 分子名称: | Muscarinic toxin-like protein 3 homolog | | 著者 | Roy, A, Zhou, X, Chong, M.Z, D'hoedt, D, Foo, C.S, Rajagopalan, N, Nirthanan, S, Bertrand, D, Sivaraman, J, Kini, R.M. | | 登録日 | 2009-05-15 | | 公開日 | 2010-01-12 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)
J.Biol.Chem., 285, 2010
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5E38
 | | Structural basis of mapping the spontaneous mutations with 5-flourouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis | | 分子名称: | Uracil phosphoribosyltransferase | | 著者 | Ghode, P, Jobichen, C, Ramachandran, S, Bifani, P, Sivaraman, J. | | 登録日 | 2015-10-02 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis of mapping the spontaneous mutations with 5-flurouracil in uracil phosphoribosyltransferase from Mycobacterium tuberculosis
Biochem.Biophys.Res.Commun., 467, 2015
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3EAA
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1PVJ
 | | Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex | | 分子名称: | (3R)-3-{[(BENZYLOXY)CARBONYL]AMINO}-2-OXO-4-PHENYLBUTANE-1-DIAZONIUM, pyrogenic exotoxin B | | 著者 | Ziomek, E, Sivaraman, J, Doran, J, Menard, R, Cygler, M. | | 登録日 | 2003-06-27 | | 公開日 | 2004-09-28 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Inhibition of autoprocessing of the streptococcal pyrogenic exotoxin B (speB). Crystal structure of the proenzyme-inhibitor complex
To be published
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3BUN
 | | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 | | 分子名称: | 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL | | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | | 登録日 | 2008-01-03 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
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3BUX
 | | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | | 分子名称: | 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL | | 著者 | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | | 登録日 | 2008-01-03 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
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5XWE
 | | Structure of a three finger toxin from Ophiophagus hannah venom | | 分子名称: | CHLORIDE ION, GLYCEROL, Weak toxin DE-1 homolog 1, ... | | 著者 | Jobichen, C, Roy, A, Kini, R.M, Sivaraman, J. | | 登録日 | 2017-06-29 | | 公開日 | 2018-07-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of a three finger toxin from Ophiophagus hannah venom
To Be Published
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1CJL
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5YDX
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5YDY
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2PY2
 | | Structure of Herring Type II Antifreeze Protein | | 分子名称: | Antifreeze protein type II, CALCIUM ION | | 著者 | Liu, Y, Li, Z, Lin, Q, Seetharaman, J, Sivaraman, J, Hew, C.-L. | | 登録日 | 2007-05-15 | | 公開日 | 2007-06-26 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure and Evolutionary Origin of Ca-Dependent Herring Type II Antifreeze Protein.
PLoS ONE, 2, 2007
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1MHW
 | | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides | | 分子名称: | 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, Cathepsin L | | 著者 | Chowdhury, S, Sivaraman, J, Wang, J, Devanathan, G, Lachance, P, Qi, H, Menard, R, Lefebvre, J, Konishi, Y, Cygler, M, Sulea, T, Purisima, E.O. | | 登録日 | 2002-08-21 | | 公開日 | 2002-12-11 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
J.Med.Chem., 45, 2002
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2QCY
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6K3O
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6K4M
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6K43
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3BC3
 | | Exploring inhibitor binding at the S subsites of cathepsin L | | 分子名称: | Cathepsin L heavy and light chains, S-benzyl-N-(biphenyl-4-ylacetyl)-L-cysteinyl-N~5~-(diaminomethyl)-D-ornithyl-N-(2-phenylethyl)-L-tyrosinamide | | 著者 | Chowdhury, S.F, Joseph, L, Kumar, S, Tulsidas, S.R, Bhat, S, Ziomek, E, Nard, R.M, Sivaraman, J, Purisima, E.O. | | 登録日 | 2007-11-12 | | 公開日 | 2008-03-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Exploring inhibitor binding at the S' subsites of cathepsin L
J.Med.Chem., 51, 2008
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1MIR
 | | RAT PROCATHEPSIN B | | 分子名称: | PROCATHEPSIN B | | 著者 | Cygler, M, Sivaraman, J, Grochulski, P, Coulombe, R, Storer, A.C, Mort, J.S. | | 登録日 | 1996-01-12 | | 公開日 | 1997-01-11 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion.
Structure, 4, 1996
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3E3C
 | | Structure of GrlR-lipid complex | | 分子名称: | (2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL HEXANOATE, L0044 | | 著者 | Jobichen, C, Sivaraman, J. | | 登録日 | 2008-08-07 | | 公開日 | 2009-04-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Identification and characterization of the lipid binding property of GrlR, a locus of enterocyte effacement regulator.
Biochem.J., 2009
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3EBK
 | | Crystal structure of major allergens, Bla g 4 from cockroaches | | 分子名称: | Allergen Bla g 4 | | 著者 | Tan, Y.W, Chan, S.L, Chew, F.T, Sivaraman, J, Mok, Y.K. | | 登録日 | 2008-08-28 | | 公開日 | 2008-12-02 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
J.Biol.Chem., 284, 2008
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3EBW
 | | Crystal structure of major allergens, Per a 4 from cockroaches | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Per a 4 allergen | | 著者 | Tan, Y.W, Chan, S.L, Chew, F.T, Sivaraman, J, Mok, Y.K. | | 登録日 | 2008-08-28 | | 公開日 | 2008-12-02 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
J.Biol.Chem., 284, 2008
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3ELP
 | | Structure of cystationine gamma lyase | | 分子名称: | Cystathionine gamma-lyase | | 著者 | Sun, Q, Sivaraman, J. | | 登録日 | 2008-09-23 | | 公開日 | 2008-11-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S
J.Biol.Chem., 284, 2009
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