3O2U
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![BU of 3o2u by Molmil](/molmil-images/mine/3o2u) | S. cerevisiae Ubc12 | 分子名称: | GLYCEROL, NEDD8-conjugating enzyme UBC12 | 著者 | Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A. | 登録日 | 2010-07-22 | 公開日 | 2010-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | A dual E3 mechanism for Rub1 ligation to Cdc53. Mol.Cell, 39, 2010
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3O2P
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![BU of 3o2p by Molmil](/molmil-images/mine/3o2p) | A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB) | 分子名称: | Cell division control protein 53, Defective in cullin neddylation protein 1, GLYCEROL | 著者 | Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A. | 登録日 | 2010-07-22 | 公開日 | 2010-09-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.233 Å) | 主引用文献 | A dual E3 mechanism for Rub1 ligation to Cdc53. Mol.Cell, 39, 2010
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3ONH
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![BU of 3onh by Molmil](/molmil-images/mine/3onh) | Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways | 分子名称: | Ubiquitin-activating enzyme E1-like | 著者 | Wang, J, Taherbhoy, A.M, Hunt, H.W, Seyedin, S.N, Miller, D.W, Huang, D.T, Schulman, B.A. | 登録日 | 2010-08-28 | 公開日 | 2011-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways. Plos One, 5, 2010
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3O6B
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![BU of 3o6b by Molmil](/molmil-images/mine/3o6b) | A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB) low resolution | 分子名称: | Cell division control protein 53, Defective in cullin neddylation protein 1 | 著者 | Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A. | 登録日 | 2010-07-28 | 公開日 | 2010-09-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A dual E3 mechanism for Rub1 ligation to Cdc53. Mol.Cell, 39, 2010
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3ONG
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![BU of 3ong by Molmil](/molmil-images/mine/3ong) | Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways | 分子名称: | SUMO-conjugating enzyme UBC9, Ubiquitin-activating enzyme E1-like | 著者 | Wang, J, Taherbhoy, A.M, Hunt, H.W, Seyedin, S.N, Miller, D.W, Huang, D.T, Schulman, B.A. | 登録日 | 2010-08-28 | 公開日 | 2011-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways. Plos One, 5, 2010
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6OJJ
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6P5W
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![BU of 6p5w by Molmil](/molmil-images/mine/6p5w) | Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1-phenyl-4-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide | 分子名称: | 3-methyl-N-[(4S,5S)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide, Lysozyme,DCN1-like protein 1 chimera | 著者 | Guy, R.K, Kim, H.S, Hammill, J.T, Scott, D.C, Schulman, B.A. | 登録日 | 2019-05-31 | 公開日 | 2019-09-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. J.Med.Chem., 62, 2019
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6P5V
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![BU of 6p5v by Molmil](/molmil-images/mine/6p5v) | Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-methylbenzamide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Lysozyme,DCN1-like protein 1 fusion, N-[(4S,5S)-1-[(1S)-cyclohex-3-en-1-yl]-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-methylbenzamide | 著者 | Guy, R.K, Kim, H.S, Hammill, J.T, Scott, D.C, Schulman, B.A. | 登録日 | 2019-05-31 | 公開日 | 2019-09-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | 主引用文献 | Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. J.Med.Chem., 62, 2019
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4GAO
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![BU of 4gao by Molmil](/molmil-images/mine/4gao) | DCNL complex with N-terminally acetylated NEDD8 E2 peptide | 分子名称: | BROMIDE ION, DCN1-like protein 2, NEDD8-conjugating enzyme Ubc12 | 著者 | Monda, J.K, Scott, D.C, Miller, D.J, Harper, J.W, Bennett, E.J, Schulman, B.A. | 登録日 | 2012-07-25 | 公開日 | 2012-11-28 | 最終更新日 | 2013-01-30 | 実験手法 | X-RAY DIFFRACTION (3.28 Å) | 主引用文献 | Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes. Structure, 21, 2013
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4GSJ
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![BU of 4gsj by Molmil](/molmil-images/mine/4gsj) | Crystal structure of Atg7 NTD K14A F16A D18A mutant | 分子名称: | CITRIC ACID, ISOPROPYL ALCOHOL, Ubiquitin-like modifier-activating enzyme ATG7 | 著者 | Kaiser, S.E, Mao, K, Taherbhoy, A.M, Yu, S, Olszewski, J.L, Duda, D.M, Kurinov, I, Deng, A, Fenn, T.D, Klionsky, D.J, Schulman, B.A. | 登録日 | 2012-08-27 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | 主引用文献 | Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat.Struct.Mol.Biol., 19, 2012
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4GSL
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![BU of 4gsl by Molmil](/molmil-images/mine/4gsl) | Crystal structure of an Atg7-Atg3 crosslinked complex | 分子名称: | Autophagy-related protein 3, Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION | 著者 | Kaiser, S.E, Mao, K, Taherbhoy, A.M, Yu, S, Olszewski, J.L, Duda, D.M, Kurinov, I, Deng, A, Fenn, T.D, Klionsky, D.J, Schulman, B.A. | 登録日 | 2012-08-27 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | 主引用文献 | Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat.Struct.Mol.Biol., 19, 2012
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4GSK
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![BU of 4gsk by Molmil](/molmil-images/mine/4gsk) | Crystal structure of an Atg7-Atg10 crosslinked complex | 分子名称: | Ubiquitin-like modifier-activating enzyme ATG7, Ubiquitin-like-conjugating enzyme ATG10, ZINC ION | 著者 | Kaiser, S.E, Mao, K, Taherbhoy, A.M, Yu, S, Olszewski, J.L, Duda, D.M, Kurinov, I, Deng, A, Fenn, T.D, Klionsky, D.J, Schulman, B.A. | 登録日 | 2012-08-27 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat.Struct.Mol.Biol., 19, 2012
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4GBA
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![BU of 4gba by Molmil](/molmil-images/mine/4gba) | DCNL complex with N-terminally acetylated NEDD8 E2 peptide | 分子名称: | DCN1-like protein 3, NEDD8-conjugating enzyme UBE2F | 著者 | Monda, J.K, Scott, D.C, Miller, D.J, Harper, J.W, Bennett, E.J, Schulman, B.A. | 登録日 | 2012-07-26 | 公開日 | 2012-11-28 | 最終更新日 | 2013-01-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes. Structure, 21, 2013
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4F52
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![BU of 4f52 by Molmil](/molmil-images/mine/4f52) | Structure of a Glomulin-RBX1-CUL1 complex | 分子名称: | Cullin-1, E3 ubiquitin-protein ligase RBX1, Glomulin, ... | 著者 | Duda, D.M, Olszewski, J.L, Schulman, B.A. | 登録日 | 2012-05-11 | 公開日 | 2012-09-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface. Mol.Cell, 47, 2012
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8PMQ
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![BU of 8pmq by Molmil](/molmil-images/mine/8pmq) | Catalytic module of yeast GID E3 ligase bound to multiphosphorylated Ubc8~ubiquitin | 分子名称: | E3 ubiquitin-protein ligase RMD5, Protein FYV10, Ubiquitin, ... | 著者 | Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A. | 登録日 | 2023-06-29 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Mol.Cell, 84, 2024
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8R5H
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![BU of 8r5h by Molmil](/molmil-images/mine/8r5h) | Ubiquitin ligation to neosubstrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-VHL-MZ1 with trapped UBE2R2~donor UB-BRD4 BD2 | 分子名称: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 5-azanylpentan-2-one, Bromodomain-containing protein 4, ... | 著者 | Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. | 登録日 | 2023-11-16 | 公開日 | 2024-02-21 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
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3RTR
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![BU of 3rtr by Molmil](/molmil-images/mine/3rtr) | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases | 分子名称: | Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION | 著者 | Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A. | 登録日 | 2011-05-03 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases. Nat.Struct.Mol.Biol., 18, 2011
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3T7H
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![BU of 3t7h by Molmil](/molmil-images/mine/3t7h) | Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway | 分子名称: | Ubiquitin-like modifier-activating enzyme ATG7 | 著者 | Taherbhoy, A.M, Tait, S.W, Kaiser, S.E, Williams, A.H, Deng, A, Nourse, A, Hammel, M, Kurinov, I, Rock, C.O, Green, D.R, Schulman, B.A. | 登録日 | 2011-07-30 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway. Mol.Cell, 44, 2011
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3T7G
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![BU of 3t7g by Molmil](/molmil-images/mine/3t7g) | Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway | 分子名称: | Autophagy-related protein 3, Ubiquitin-like modifier-activating enzyme ATG7 | 著者 | Taherbhoy, A.M, Tait, S.W, Kaiser, S.E, Williams, A.H, Deng, A, Nourse, A, Hammel, M, Kurinov, I, Rock, C.O, Green, D.R, Schulman, B.A. | 登録日 | 2011-07-30 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway. Mol.Cell, 44, 2011
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7ADO
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![BU of 7ado by Molmil](/molmil-images/mine/7ado) | Cryo-EM structure of human ER membrane protein complex in lipid nanodiscs | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ... | 著者 | Braeuning, B, Prabu, J.R, Miller-Vedam, L.E, Weissman, J.S, Frost, A, Schulman, B.A. | 登録日 | 2020-09-15 | 公開日 | 2020-12-02 | 最終更新日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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3T7F
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![BU of 3t7f by Molmil](/molmil-images/mine/3t7f) | Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway | 分子名称: | Ubiquitin-like modifier-activating enzyme ATG7 | 著者 | Taherbhoy, A.M, Tait, S.W, Kaiser, S.E, Williams, A.H, Deng, A, Nourse, A, Hammel, M, Kurinov, I, Rock, C.O, Green, D.R, Schulman, B.A. | 登録日 | 2011-07-30 | 公開日 | 2011-11-23 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway. Mol.Cell, 44, 2011
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3TDI
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![BU of 3tdi by Molmil](/molmil-images/mine/3tdi) | yeast Cul1WHB-Dcn1P acetylated Ubc12N complex | 分子名称: | Defective in cullin neddylation protein 1, NEDD8-conjugating enzyme UBC12 | 著者 | Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A. | 登録日 | 2011-08-11 | 公開日 | 2011-10-12 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science, 334, 2011
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3TDZ
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![BU of 3tdz by Molmil](/molmil-images/mine/3tdz) | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: Structure of a human Cul1WHB-Dcn1P-stapled acetylated Ubc12N complex | 分子名称: | Cullin-1, DCN1-like protein 1, STAPLED PEPTIDE | 著者 | Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A. | 登録日 | 2011-08-11 | 公開日 | 2011-10-12 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science, 334, 2011
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3TDU
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![BU of 3tdu by Molmil](/molmil-images/mine/3tdu) | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: Structure of a human Cul1WHB-Dcn1P-acetylated Ubc12N complex | 分子名称: | Cullin-1, DCN1-like protein 1, NEDD8-conjugating enzyme Ubc12 | 著者 | Scott, D.C, Monda, J.K, Bennett, E.J, Harper, J.W, Schulman, B.A. | 登録日 | 2011-08-11 | 公開日 | 2011-10-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science, 334, 2011
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7ADP
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![BU of 7adp by Molmil](/molmil-images/mine/7adp) | Cryo-EM structure of human ER membrane protein complex in GDN detergent | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ... | 著者 | Braeuning, B, Prabu, J.R, Miller-Vedam, L.E, Weissman, J.S, Frost, A, Schulman, B.A. | 登録日 | 2020-09-15 | 公開日 | 2020-12-02 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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