1YRG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yrg by Molmil](/molmil-images/mine/1yrg) | THE CRYSTAL STRUCTURE OF RNA1P: A NEW FOLD FOR A GTPASE-ACTIVATING PROTEIN | 分子名称: | GTPASE-ACTIVATING PROTEIN RNA1_SCHPO | 著者 | Hillig, R.C, Renault, L, Vetter, I.R, Drell, T, Wittinghofer, A, Becker, J. | 登録日 | 1999-03-29 | 公開日 | 2000-03-29 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | The crystal structure of rna1p: a new fold for a GTPase-activating protein. Mol.Cell, 3, 1999
|
|
5U0P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5u0p by Molmil](/molmil-images/mine/5u0p) | Cryo-EM structure of the transcriptional Mediator | 分子名称: | Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... | 著者 | Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. | 登録日 | 2016-11-26 | 公開日 | 2017-03-08 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Mediator structure and rearrangements required for holoenzyme formation. Nature, 544, 2017
|
|
1I3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1i3v by Molmil](/molmil-images/mine/1i3v) | THREE-DIMENSIONAL STRUCTURE OF A LAMA VHH DOMAIN UNLIGANDED | 分子名称: | ANTIBODY VHH LAMA DOMAIN | 著者 | Spinelli, S, Tegoni, M, Frenken, L, van Vliet, C, Cambillau, C. | 登録日 | 2001-02-16 | 公開日 | 2001-08-08 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Lateral recognition of a dye hapten by a llama VHH domain. J.Mol.Biol., 311, 2001
|
|
1HE9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1he9 by Molmil](/molmil-images/mine/1he9) | Crystal structure of the GAP domain of the Pseudomonas aeruginosa ExoS toxin | 分子名称: | EXOENZYME S | 著者 | Wurtele, M, Renault, L, Barbieri, J.T, Wittinghofer, A, Wolf, E. | 登録日 | 2000-11-21 | 公開日 | 2001-03-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of the Exos Gtpase Activating Domain FEBS Lett., 491, 2001
|
|
5U0S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5u0s by Molmil](/molmil-images/mine/5u0s) | Cryo-EM structure of the Mediator-RNAPII complex | 分子名称: | Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... | 著者 | Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. | 登録日 | 2016-11-26 | 公開日 | 2017-03-08 | 最終更新日 | 2020-01-01 | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | 主引用文献 | Mediator structure and rearrangements required for holoenzyme formation. Nature, 544, 2017
|
|
1I3U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1i3u by Molmil](/molmil-images/mine/1i3u) | THREE-DIMENSIONAL STRUCTURE OF A LLAMA VHH DOMAIN COMPLEXED WITH THE DYE RR1 | 分子名称: | 5-(4,6-DIAMINO-[1,3,5]TRIAZIN-2-YLAMINO)-4-HYDROXY-3-(2-SULFO-PHENYLAZO)-NAPHTHALENE-2,7-DISULFONIC ACID, ANTIBODY VHH LAMA DOMAIN, SULFATE ION | 著者 | Spinelli, S, Tegoni, M, Frenken, L, van Vliet, C, Cambillau, C. | 登録日 | 2001-02-16 | 公開日 | 2001-08-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Lateral recognition of a dye hapten by a llama VHH domain. J.Mol.Biol., 311, 2001
|
|
1OIV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1oiv by Molmil](/molmil-images/mine/1oiv) | X-ray structure of the small G protein Rab11a in complex with GDP | 分子名称: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, RAS-RELATED PROTEIN RAB-11A, ... | 著者 | Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J. | 登録日 | 2003-06-26 | 公開日 | 2004-01-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes J.Biol.Chem., 279, 2004
|
|
1JLN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1jln by Molmil](/molmil-images/mine/1jln) | Crystal structure of the catalytic domain of protein tyrosine phosphatase PTP-SL/BR7 | 分子名称: | Protein Tyrosine Phosphatase, receptor type, R | 著者 | Szedlacsek, S.E, Aricescu, A.R, Fulga, T.A, Renault, L, Scheidig, A.J. | 登録日 | 2001-07-16 | 公開日 | 2001-08-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation. J.Mol.Biol., 311, 2001
|
|
1OIW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1oiw by Molmil](/molmil-images/mine/1oiw) | X-ray structure of the small G protein Rab11a in complex with GTPgammaS | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, RAS-RELATED PROTEIN RAB-11A | 著者 | Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J. | 登録日 | 2003-06-26 | 公開日 | 2004-01-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The Structural Gdp/GTP Cycle of Rab11 Reveals a Novel Interface Involved in the Dynamics of Recycling Endosomes J.Biol.Chem., 279, 2004
|
|
1DG3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1dg3 by Molmil](/molmil-images/mine/1dg3) | STRUCTURE OF HUMAN GUANYLATE BINDING PROTEIN-1 IN NUCLEOTIDE FREE FORM | 分子名称: | PROTEIN (INTERFERON-INDUCED GUANYLATE-BINDING PROTEIN 1) | 著者 | Prakash, B, Praefcke, G.J.K, Renault, L, Wittinghofer, A, Herrmann, C. | 登録日 | 1999-11-23 | 公開日 | 2000-10-11 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Nature, 403, 2000
|
|
1E8J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1e8j by Molmil](/molmil-images/mine/1e8j) | SOLUTION STRUCTURE OF DESULFOVIBRIO GIGAS ZINC RUBREDOXIN, NMR, 20 STRUCTURES | 分子名称: | RUBREDOXIN | 著者 | Lamosa, P, Brennan, L, Vis, H, Turner, D.L, Santos, H. | 登録日 | 2000-09-21 | 公開日 | 2001-10-18 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of Desulfovibrio gigas rubredoxin: a model for studying protein stabilization by compatible solutes. Extremophiles, 5, 2001
|
|
1SJV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sjv by Molmil](/molmil-images/mine/1sjv) | Three-Dimensional Structure of a Llama VHH Domain Swapping | 分子名称: | r9 | 著者 | Spinelli, S, Desmyter, A, Frenken, L, Verrips, T, Cambillau, C. | 登録日 | 2004-03-04 | 公開日 | 2004-06-01 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Domain swapping of a llama VHH domain builds a crystal-wide beta-sheet structure. Febs Lett., 564, 2004
|
|
2K3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2k3v by Molmil](/molmil-images/mine/2k3v) | Solution Structure of a Tetrahaem Cytochrome from Shewanella Frigidimarina | 分子名称: | HEME C, Tetraheme cytochrome c-type | 著者 | Paixao, V.B, Turner, D.L, Salgueiro, C.A, Brennan, L, Reid, G.A, Chapman, S.K. | 登録日 | 2008-05-19 | 公開日 | 2009-03-31 | 最終更新日 | 2019-10-02 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of a tetraheme cytochrome from Shewanella frigidimarina reveals a novel family structural motif Biochemistry, 47, 2008
|
|
1SJX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1sjx by Molmil](/molmil-images/mine/1sjx) | Three-Dimensional Structure of a Llama VHH Domain OE7 binding the cell wall protein Malf1 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, immunoglobulin VH domain | 著者 | Dolk, E, van der Vaart, M, Hulsik, D.L, Vriend, G, de Haard, H, Spinelli, S, Cambillau, C, Frenken, L, Verrips, T. | 登録日 | 2004-03-04 | 公開日 | 2005-03-15 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo. Appl.Environ.Microbiol., 71, 2005
|
|
1OIX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1oix by Molmil](/molmil-images/mine/1oix) | X-ray structure of the small G protein Rab11a in complex with GDP and Pi | 分子名称: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Pasqualato, S, Senic-Matuglia, F, Renault, L, Goud, B, Salamero, J, Cherfils, J. | 登録日 | 2003-06-26 | 公開日 | 2005-01-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystallographic Evidence for Substrate-Assisted GTP Hydrolysis by a Small GTP Binding Protein Structure, 13, 2005
|
|
4E4X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4e4x by Molmil](/molmil-images/mine/4e4x) | Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor | 分子名称: | N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | 著者 | Voegtli, W.C, Sturgis, H.L. | 登録日 | 2012-03-13 | 公開日 | 2012-05-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 22, 2012
|
|
4XJ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4xj0 by Molmil](/molmil-images/mine/4xj0) | Crystal structure of ERK2 in complex with an inhibitor 14K | 分子名称: | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1H)-one, Mitogen-activated protein kinase 1 | 著者 | Yin, J, Wang, W. | 登録日 | 2015-01-08 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2. J.Med.Chem., 58, 2015
|
|
3PRF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3prf by Molmil](/molmil-images/mine/3prf) | Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor | 分子名称: | 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol, Serine/threonine-protein kinase B-raf | 著者 | Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J. | 登録日 | 2010-11-29 | 公開日 | 2011-02-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3PPK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ppk by Molmil](/molmil-images/mine/3ppk) | Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor | 分子名称: | 3-[(5-hydroxynaphthalen-2-yl)amino]-N-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamide, Serine/threonine-protein kinase B-raf | 著者 | Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J. | 登録日 | 2010-11-24 | 公開日 | 2011-02-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3PPJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ppj by Molmil](/molmil-images/mine/3ppj) | Human B-Raf Kinase in Complex with a Furopyridine Inhibitor | 分子名称: | Serine/threonine-protein kinase B-raf, methyl 3-{[(5S)-1-(hydroxyamino)-5H-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate | 著者 | Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J. | 登録日 | 2010-11-24 | 公開日 | 2011-02-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3PRI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3pri by Molmil](/molmil-images/mine/3pri) | Crystal Structure of Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor | 分子名称: | 3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1H-indazol-3-yl)propan-1-ol, Serine/threonine-protein kinase B-raf | 著者 | Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J. | 登録日 | 2010-11-29 | 公開日 | 2011-02-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 21, 2011
|
|
8FCC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fcc by Molmil](/molmil-images/mine/8fcc) | |
8FCD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fcd by Molmil](/molmil-images/mine/8fcd) | HIV-1 Reverse Transcriptase in complex with 6-membered bicyclic core NNRTI | 分子名称: | 4-[(8-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino]benzonitrile, L(+)-TARTARIC ACID, p51 RT, ... | 著者 | Lansdon, E.B. | 登録日 | 2022-12-01 | 公開日 | 2023-02-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties. J.Med.Chem., 66, 2023
|
|
8FCE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fce by Molmil](/molmil-images/mine/8fce) | HIV-1 Reverse Transcriptase in complex with 7-membered bicyclic core NNRTI | 分子名称: | 4-[(9-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]benzonitrile, L(+)-TARTARIC ACID, p51 RT, ... | 著者 | Lansdon, E.B. | 登録日 | 2022-12-01 | 公開日 | 2023-02-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties. J.Med.Chem., 66, 2023
|
|
4EHG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ehg by Molmil](/molmil-images/mine/4ehg) | B-Raf Kinase Domain in Complex with an Aminopyridimine-based Inhibitor | 分子名称: | N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | 著者 | Voegtli, W.C. | 登録日 | 2012-04-02 | 公開日 | 2013-04-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties. J.Med.Chem., 55, 2012
|
|