4EHG

B-Raf Kinase Domain in Complex with an Aminopyridimine-based Inhibitor

Summary for 4EHG

Entry DOI	10.2210/pdb4ehg/pdb
Related	4EHE
Descriptor	Serine/threonine-protein kinase B-raf, N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide (2 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (By similarity): P15056
Total number of polymer chains	2
Total formula weight	71356.09
Authors	Voegtli, W.C. (deposition date: 2012-04-02, release date: 2013-04-24, Last modification date: 2024-02-28)
Primary citation	Mathieu, S.,Gradl, S.N.,Ren, L.,Wen, Z.,Aliagas, I.,Gunzner-Toste, J.,Lee, W.,Pulk, R.,Zhao, G.,Alicke, B.,Boggs, J.W.,Buckmelter, A.J.,Choo, E.F.,Dinkel, V.,Gloor, S.L.,Gould, S.E.,Hansen, J.D.,Hastings, G.,Hatzivassiliou, G.,Laird, E.R.,Moreno, D.,Ran, Y.,Voegtli, W.C.,Wenglowsky, S.,Grina, J.,Rudolph, J. Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties. J.Med.Chem., 55:2869-2881, 2012 Cited by PubMed: 22335519 DOI: 10.1021/jm300016v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation