3PPJ

Human B-Raf Kinase in Complex with a Furopyridine Inhibitor

Summary for 3PPJ

Related3PPK 3PRF 3PRI
DescriptorSerine/threonine-protein kinase B-raf, methyl 3-{[(5S)-1-(hydroxyamino)-5H-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate (2 entities in total)
Functional Keywordsprotein kinase, atp-competitive inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity) P15056
Total number of polymer chains2
Total molecular weight71109.92
Authors
Voegtli, W.C.,Vigers, G.P.A.,Morales, T.,Brandhuber, B.J. (deposition date: 2010-11-24, release date: 2011-02-02, Last modification date: 2011-07-13)
Primary citation
Ren, L.,Wenglowsky, S.,Miknis, G.,Rast, B.,Buckmelter, A.J.,Ely, R.J.,Schlachter, S.,Laird, E.R.,Randolph, N.,Callejo, M.,Martinson, M.,Galbraith, S.,Brandhuber, B.J.,Vigers, G.,Morales, T.,Voegtli, W.C.,Lyssikatos, J.
Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 21:1243-1247, 2011
PubMed: 21251822 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2010.12.061
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.235141.7%10.4%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution