3PPJ
Human B-Raf Kinase in Complex with a Furopyridine Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 307 | 35217.6 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B | methyl 3-{[(5S)-1-(hydroxyamino)-5H-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate | non-polymer | 337.3 | 2 | Chemie (FOI) |
Sequence modifications
A, B: 432 - 726 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Met 420 | - | expression tag |
Asp 421 | - | expression tag |
Arg 422 | - | expression tag |
Gly 423 | - | expression tag |
Ser 424 | - | expression tag |
His 425 | - | expression tag |
His 426 | - | expression tag |
His 427 | - | expression tag |
His 428 | - | expression tag |
His 429 | - | expression tag |
His 430 | - | expression tag |
Gly 431 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70435.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 674.7 | |
All* | Total formula weight | 71109.9 |