5AV3
 
 | |
5CG6
 | | Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate and isopentenyl pyrophosphate | | 分子名称: | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, ... | | 著者 | Yokoyama, T, Mizuguchi, M, Ostermann, A, Kusaka, K, Niimura, N, Schrader, T.E, Tanaka, I. | | 登録日 | 2015-07-09 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | NEUTRON DIFFRACTION (1.7 Å), X-RAY DIFFRACTION | | 主引用文献 | Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase
J.Med.Chem., 58, 2015
|
|
7X7I
 | | Ancestral L-Lys oxidase (AncLLysO-2) ligand free form | | 分子名称: | FAD dependent enzyme, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Motoyama, T, Ishida, C, Hasebe, F, Ito, S, Nakano, S. | | 登録日 | 2022-03-09 | | 公開日 | 2023-01-18 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Reaction Mechanism of Ancestral l-Lys alpha-Oxidase from Caulobacter Species Studied by Biochemical, Structural, and Computational Analysis
Acs Omega, 7, 2022
|
|
7X7J
 | | Ancestral L-Lys oxidase (AncLLysO-2) L-Lys binding form | | 分子名称: | FAD dependent enzyme, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE | | 著者 | Motoyama, T, Ishida, C, Hasebe, F, Ito, S, Nakano, S. | | 登録日 | 2022-03-09 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Reaction Mechanism of Ancestral l-Lys alpha-Oxidase from Caulobacter Species Studied by Biochemical, Structural, and Computational Analysis
Acs Omega, 7, 2022
|
|
8IG1
 | |
7X7K
 | | Ancestral L-Lys oxidase (AncLLysO-2) L-Arg binding form | | 分子名称: | ARGININE, FAD dependent enzyme, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Motoyama, T, Ishida, C, Hasebe, F, Ito, S, Nakano, S. | | 登録日 | 2022-03-09 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Reaction Mechanism of Ancestral l-Lys alpha-Oxidase from Caulobacter Species Studied by Biochemical, Structural, and Computational Analysis
Acs Omega, 7, 2022
|
|
4Y9E
 | | Crystal structure of V30M mutated transthyretin in complex with gamma-mangostin | | 分子名称: | 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, CHLORIDE ION, Transthyretin | | 著者 | Yokoyama, T, Mizuguchi, M. | | 登録日 | 2015-02-17 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor
Sci Rep, 5, 2015
|
|
4Y9B
 | | Crystal structure of V30M mutated transthyretin in complex with alpha-mangostin | | 分子名称: | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Yokoyama, T, Mizuguchi, M. | | 登録日 | 2015-02-17 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor
Sci Rep, 5, 2015
|
|
4Y9F
 | | Crystal structure of V30M mutated transthyretin with bromide in complex with gamma-mangostin | | 分子名称: | 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, BROMIDE ION, Transthyretin | | 著者 | Yokoyama, T, Mizuguchi, M. | | 登録日 | 2015-02-17 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor
Sci Rep, 5, 2015
|
|
4Y9C
 | | Crystal structure of V30M mutated transthyretin with bromide in complex with alpha-mangostin | | 分子名称: | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, BROMIDE ION, Transthyretin | | 著者 | Yokoyama, T, Mizuguchi, M. | | 登録日 | 2015-02-17 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor
Sci Rep, 5, 2015
|
|
4Y9G
 | | Crystal structure of V30M mutated transthyretin in complex with 3-isomangostin | | 分子名称: | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, Transthyretin | | 著者 | Yokoyama, T, Mizuguchi, M. | | 登録日 | 2015-02-17 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor
Sci Rep, 5, 2015
|
|
5AV1
 | |
5AUU
 | |
5AUY
 | | Crystal structure of DAPK1 in complex with morin. | | 分子名称: | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, Death-associated protein kinase 1 | | 著者 | Yokoyama, T, Mizuguchi, M. | | 登録日 | 2015-06-10 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids.
J.Med.Chem., 58, 2015
|
|
5AUZ
 | |
5AUW
 | | Crystal structure of DAPK1 in complex with quercetin. | | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Death-associated protein kinase 1 | | 著者 | Yokoyama, T, Mizuguchi, M. | | 登録日 | 2015-06-10 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids.
J.Med.Chem., 58, 2015
|
|
5AV4
 | |
5AV2
 | |
6M1U
 | |
5Y1G
 | | Monomeric L-threonine 3-dehydrogenase from metagenome database (AKB and NADH bound form) | | 分子名称: | 2-AMINO-3-KETOBUTYRIC ACID, NAD dependent epimerase/dehydratase family, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Motoyama, T, Nakano, S, Yamamoto, Y, Tokiwa, H, Asano, Y, Ito, S. | | 登録日 | 2017-07-20 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Product Release Mechanism Associated with Structural Changes in Monomeric l-Threonine 3-Dehydrogenase.
Biochemistry, 56, 2017
|
|
5Y1E
 | | monomeric L-threonine 3-dehydrogenase from metagenome database (L-Ser and NAD+ bound form) | | 分子名称: | NAD dependent epimerase/dehydratase family, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SERINE | | 著者 | Motoyama, T, Nakano, S, Yamamoto, Y, Tokiwa, H, Asano, Y, Ito, S. | | 登録日 | 2017-07-20 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Product Release Mechanism Associated with Structural Changes in Monomeric l-Threonine 3-Dehydrogenase.
Biochemistry, 56, 2017
|
|
5Y1D
 | | Monomeric L-threonine 3-dehydrogenase from metagenome database (apo form) | | 分子名称: | NAD dependent epimerase/dehydratase family | | 著者 | Motoyama, T, Nakano, S, Yamamoto, Y, Tokiwa, H, Asano, Y, Ito, S. | | 登録日 | 2017-07-20 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Product Release Mechanism Associated with Structural Changes in Monomeric l-Threonine 3-Dehydrogenase.
Biochemistry, 56, 2017
|
|
6AA4
 | | Crystal structure of MTH1 in complex with alpha-mangostin (cocktail No. 9) | | 分子名称: | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ... | | 著者 | Yokoyama, T, Kitakami, R, Mizuguchi, M. | | 登録日 | 2018-07-17 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.
Eur J Med Chem, 167, 2019
|
|
6AA3
 | | Crystal structure of MTH1 in apo form (cocktail No. 1) | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ZINC ION | | 著者 | Yokoyama, T, Kitakami, R, Mizuguchi, M. | | 登録日 | 2018-07-17 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | | 主引用文献 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.
Eur J Med Chem, 167, 2019
|
|
6AA5
 | | Crystal structure of MTH1 in complex with 3-isomangostin | | 分子名称: | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ... | | 著者 | Yokoyama, T, Kitakami, R, Mizuguchi, M. | | 登録日 | 2018-07-17 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening.
Eur J Med Chem, 167, 2019
|
|
