7ERK
Crystal structure of V30M-TTR in complex with dasatinib
Summary for 7ERK
Entry DOI | 10.2210/pdb7erk/pdb |
Descriptor | Transthyretin, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total) |
Functional Keywords | amyloidosis, inhibitor, complex, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 35661.18 |
Authors | Yokoyama, T.,Kashihara, M.,Mizuguchi, M. (deposition date: 2021-05-06, release date: 2021-11-24, Last modification date: 2023-11-29) |
Primary citation | Yokoyama, T.,Kashihara, M.,Mizuguchi, M. Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J.Med.Chem., 64:14344-14357, 2021 Cited by PubMed: 34547896DOI: 10.1021/acs.jmedchem.1c00823 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.703 Å) |
Structure validation
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