7ERK

Crystal structure of V30M-TTR in complex with dasatinib

Summary for 7ERK

Entry DOI	10.2210/pdb7erk/pdb
Descriptor	Transthyretin, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total)
Functional Keywords	amyloidosis, inhibitor, complex, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	35661.18
Authors	Yokoyama, T.,Kashihara, M.,Mizuguchi, M. (deposition date: 2021-05-06, release date: 2021-11-24, Last modification date: 2023-11-29)
Primary citation	Yokoyama, T.,Kashihara, M.,Mizuguchi, M. Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. J.Med.Chem., 64:14344-14357, 2021 Cited by PubMed: 34547896 DOI: 10.1021/acs.jmedchem.1c00823 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.703 Å)

Structure validation