7ERK

Crystal structure of V30M-TTR in complex with dasatinib

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 1N1 A 201

Chain	Residue
A	LYS15
A	LEU110
A	SER117
A	SER117
A	THR119
A	THR119
A	VAL121
A	LYS15
A	LEU17
A	LEU17
A	GLU54
A	HIS56
A	ALA108
A	ALA108
A	ALA109

---

site_id	AC2
Number of Residues	13
Details	binding site for residue 1N1 B 201

Chain	Residue
B	LYS15
B	LEU17
B	LEU17
B	GLU54
B	THR106
B	ALA108
B	ALA108
B	ALA109
B	LEU110
B	LEU110
B	SER117
B	SER117
B	THR119

---

Functional Information from PROSITE/UniProt

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT

Chain	Residue	Details
A	LYS15
A	GLU54
A	SER117
B	LYS15
B	GLU54
B	SER117

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E

Chain	Residue	Details
A	CYS10
B	CYS10

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012

Chain	Residue	Details
A	GLU42
B	GLU42

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767

Chain	Residue	Details
A	SER52
B	SER52

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329

Chain	Residue	Details
A	ASN98
B	ASN98

---