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REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
分子名称:	BETA-MERCAPTOETHANOL, T4 LYSOZYME
著者	Bell, J.A, Dao-Pin, S, Matthews, B.W.
登録日	1989-05-01
公開日	1990-01-15
最終更新日	2022-11-23
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science, 239, 1988

1L76

TOLERANCE OF T4 LYSOZYME TO PROLINE SUBSTITUTIONS WITHIN THE LONG INTERDOMAIN ALPHA-HELIX ILLUSTRATES THE ADAPTABILITY OF PROTEINS TO POTENTIALLY DESTABILIZING LESIONS
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Sauer, U, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. J.Biol.Chem., 267, 1992

1L69

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Zhang, X, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L73

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Zhang, X, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2020-07-22
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L24

ENHANCED PROTEIN THERMOSTABILITY FROM SITE-DIRECTED MUTATIONS THAT DECREASE THE ENTROPY OF UNFOLDING
分子名称:	T4 LYSOZYME
著者	Nicholson, H, Matthews, B.W.
登録日	1989-05-01
公開日	1990-01-15
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding. Proc.Natl.Acad.Sci.USA, 84, 1987

1L34

HIGH-RESOLUTION STRUCTURE OF THE TEMPERATURE-SENSITIVE MUTANT OF PHAGE LYSOZYME, ARG 96 (RIGHT ARROW) HIS
分子名称:	T4 LYSOZYME
著者	Weaver, L.H, Matthews, B.W.
登録日	1989-05-01
公開日	1990-01-15
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	High-resolution structure of the temperature-sensitive mutant of phage lysozyme, Arg 96----His. Biochemistry, 28, 1989

1L74

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Zhang, X, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2020-07-22
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L35

STRUCTURE OF A THERMOSTABLE DISULFIDE-BRIDGE MUTANT OF PHAGE T4 LYSOZYME SHOWS THAT AN ENGINEERED CROSSLINK IN A FLEXIBLE REGION DOES NOT INCREASE THE RIGIDITY OF THE FOLDED PROTEIN
分子名称:	T4 LYSOZYME
著者	Pjura, P.E, Matsumura, M, Wozniak, J.A, Matthews, B.W.
登録日	1989-10-26
公開日	1990-01-15
最終更新日	2024-10-30
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structure of a thermostable disulfide-bridge mutant of phage T4 lysozyme shows that an engineered cross-link in a flexible region does not increase the rigidity of the folded protein. Biochemistry, 29, 1990

1L23

ENHANCED PROTEIN THERMOSTABILITY FROM SITE-DIRECTED MUTATIONS THAT DECREASE THE ENTROPY OF UNFOLDING
分子名称:	T4 LYSOZYME
著者	Nicholson, H, Matthews, B.W.
登録日	1989-05-01
公開日	1990-01-15
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding. Proc.Natl.Acad.Sci.USA, 84, 1987

1L72

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Zhang, X, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2017-11-29
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L58

ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME
分子名称:	BETA-MERCAPTOETHANOL, T4 LYSOZYME
著者	Nicholson, H, Matthews, B.W.
登録日	1991-05-06
公開日	1991-10-15
最終更新日	2017-11-29
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	To be Published

1L64

TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Heinz, D, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc.Natl.Acad.Sci.USA, 89, 1992

1L71

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Zhang, X, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L70

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Zhang, X, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2017-11-29
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L75

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
分子名称:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
著者	Zhang, X, Matthews, B.W.
登録日	1991-09-23
公開日	1991-10-15
最終更新日	2020-07-22
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

5F3H

Structure of myostatin in complex with humanized RK35 antibody
分子名称:	Growth/differentiation factor 8, humanized RK35 antibody heavy chain, humanized RK35 antibody light chain
著者	Parris, K.D, Mosyak, L.
登録日	2015-12-02
公開日	2016-09-28
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8, 2016

5F3B

Structure of myostatin in complex with chimeric RK35 antibody
分子名称:	GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ...
著者	Parris, K.D, Mosyak, L.
登録日	2015-12-02
公開日	2016-09-28
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.76 Å)
主引用文献	Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8, 2016

4IUD

Crystal structure of an O2-tolerant [NiFe]-hydrogenase from Ralstonia eutropha in its as-isolated form with ascorbate - partly reduced state
分子名称:	CHLORIDE ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ...
著者	Hammer, M, Schmidt, A, Frielingsdorf, S, Fritsch, J, Lenz, O, Scheerer, P.
登録日	2013-01-20
公開日	2014-04-02
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Reversible [4Fe-3S] cluster morphing in an O2-tolerant [NiFe] hydrogenase. Nat.Chem.Biol., 10, 2014

4IUC

Crystal structure of an O2-tolerant [NiFe]-hydrogenase from Ralstonia eutropha in its as-isolated form - oxidized state 2
分子名称:	CHLORIDE ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ...
著者	Frielingsdorf, S, Schmidt, A, Fritsch, J, Lenz, O, Scheerer, P.
登録日	2013-01-20
公開日	2014-04-02
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Reversible [4Fe-3S] cluster morphing in an O2-tolerant [NiFe] hydrogenase. Nat.Chem.Biol., 10, 2014

4IUB

Crystal structure of an O2-tolerant [NiFe]-hydrogenase from Ralstonia eutropha in its as-isolated form - oxidized state 1
分子名称:	CHLORIDE ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ...
著者	Frielingsdorf, S, Schmidt, A, Fritsch, J, Lenz, O, Scheerer, P.
登録日	2013-01-20
公開日	2014-04-02
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.61 Å)
主引用文献	Reversible [4Fe-3S] cluster morphing in an O2-tolerant [NiFe] hydrogenase. Nat.Chem.Biol., 10, 2014

7K45

SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2E12 neutralizing antibody Fab fragment (heavy chain), S2E12 neutralizing antibody Fab fragment (light chain), ...
著者	Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2020-09-14
公開日	2020-10-07
最終更新日	2024-10-30
実験手法	ELECTRON MICROSCOPY (3.7 Å)
主引用文献	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

7K3Q

An ultra-potent human neutralizing antibody locks the SARS-CoV-2 spike in the closed conformation
分子名称:	1,2-ETHANEDIOL, Fab fragment of S2E12 monoclonal antibody, heavy chain, ...
著者	Snell, G, Czudnochowski, N, Ng, C.
登録日	2020-09-12
公開日	2020-10-07
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (1.38 Å)
主引用文献	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

7K4N

SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2E12 neutralizing antibody Fab fragment (heavy chain), ...
著者	Tortorici, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2020-09-15
公開日	2020-10-07
最終更新日	2020-12-02
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

7K43

SARS-CoV-2 spike in complex with the S2M11 neutralizing antibody Fab fragment
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2M11 Fab fragment (heavy chain), ...
著者	Tortorici, M.A, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日	2020-09-14
公開日	2020-10-07
最終更新日	2024-10-30
実験手法	ELECTRON MICROSCOPY (2.6 Å)
主引用文献	Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science, 370, 2020

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