6HIJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hij by Molmil](/molmil-images/mine/6hij) | Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked | 分子名称: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ATP-binding cassette sub-family G member 2, CHOLESTEROL, ... | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | 登録日 | 2018-08-30 | 公開日 | 2018-09-19 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat.Struct.Mol.Biol., 25, 2018
|
|
6FN1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fn1 by Molmil](/molmil-images/mine/6fn1) | |
5NIV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5niv by Molmil](/molmil-images/mine/5niv) | |
5OGL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ogl by Molmil](/molmil-images/mine/5ogl) | Structure of bacterial oligosaccharyltransferase PglB in complex with an acceptor peptide and an lipid-linked oligosaccharide analog | 分子名称: | MANGANESE (II) ION, SODIUM ION, Substrate mimicking peptide, ... | 著者 | Napiorkowska, M, Boilevin, J, Sovdat, T, Darbre, T, Reymond, J.-L, Aebi, M, Locher, K.P. | 登録日 | 2017-07-13 | 公開日 | 2017-10-25 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase. Nat. Struct. Mol. Biol., 24, 2017
|
|
5OVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ovw by Molmil](/molmil-images/mine/5ovw) | Nanobody-bound BtuF, the vitamin B12 binding protein in Escherichia coli | 分子名称: | GLYCEROL, Nanobody, Vitamin B12-binding protein | 著者 | Mireku, S.A, Sauer, M.M, Glockshuber, R, Locher, K.P. | 登録日 | 2017-08-30 | 公開日 | 2017-11-08 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.653 Å) | 主引用文献 | Structural basis of nanobody-mediated blocking of BtuF, the cognate substrate-binding protein of the Escherichia coli vitamin B12 transporter BtuCD. Sci Rep, 7, 2017
|
|
5NJ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nj3 by Molmil](/molmil-images/mine/5nj3) | Structure of an ABC transporter: complete structure | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | 著者 | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | 登録日 | 2017-03-28 | 公開日 | 2017-06-07 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structure of the human multidrug transporter ABCG2. Nature, 546, 2017
|
|
5NRP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nrp by Molmil](/molmil-images/mine/5nrp) | |
5NP4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5np4 by Molmil](/molmil-images/mine/5np4) | |
5NSA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nsa by Molmil](/molmil-images/mine/5nsa) | Beta domain of human transcobalamin bound to Co-beta-[2-(2,4-difluorophenyl)ethinyl]cobalamin | 分子名称: | 1-ethynyl-2,4-difluorobenzene, CALCIUM ION, COBALAMIN, ... | 著者 | Bloch, J.S, Ruetz, M, Krautler, B, Locher, K.P. | 登録日 | 2017-04-25 | 公開日 | 2017-09-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.273 Å) | 主引用文献 | Structure of the human transcobalamin beta domain in four distinct states. PLoS ONE, 12, 2017
|
|
5NO0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5no0 by Molmil](/molmil-images/mine/5no0) | |
5NBD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nbd by Molmil](/molmil-images/mine/5nbd) | PglK flippase in complex with inhibitory nanobody | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nanobody, WlaB protein | 著者 | Perez, C, Pardon, E, Steyaert, J, Locher, K.P. | 登録日 | 2017-03-01 | 公開日 | 2017-05-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody. Sci Rep, 7, 2017
|
|
5NJG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5njg by Molmil](/molmil-images/mine/5njg) | Structure of an ABC transporter: part of the structure that could be built de novo | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | 著者 | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | 登録日 | 2017-03-28 | 公開日 | 2017-06-07 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structure of the human multidrug transporter ABCG2. Nature, 546, 2017
|
|
6QEX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qex by Molmil](/molmil-images/mine/6qex) | |
6EJK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ejk by Molmil](/molmil-images/mine/6ejk) | Structure of a glycosyltransferase | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-glucopyranose, NerylNeryl pyrophosphate, Uridine-Diphosphate-Methylene-N-acetyl-galactosamine, ... | 著者 | Ramirez, A.S, Boilevin, J, Mehdipour, A.R, Hummer, G, Darbre, T, Reymond, J.L, Locher, K.P. | 登録日 | 2017-09-21 | 公開日 | 2018-02-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nat Commun, 9, 2018
|
|
6S7P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s7p by Molmil](/molmil-images/mine/6s7p) | Nucleotide bound ABCB4 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, MAGNESIUM ION, ... | 著者 | Olsen, J.A, Alam, A, Kowal, J, Stieger, B, Locher, K.P. | 登録日 | 2019-07-05 | 公開日 | 2019-12-25 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the human lipid exporter ABCB4 in a lipid environment. Nat.Struct.Mol.Biol., 27, 2020
|
|
6S7T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s7t by Molmil](/molmil-images/mine/6s7t) | Cryo-EM structure of human oligosaccharyltransferase complex OST-B | 分子名称: | (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl dihydrogen phosphate, (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, ... | 著者 | Ramirez, A.S, Kowal, J, Locher, K.P. | 登録日 | 2019-07-05 | 公開日 | 2019-12-18 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Science, 366, 2019
|
|
6EJI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eji by Molmil](/molmil-images/mine/6eji) | Structure of a glycosyltransferase | 分子名称: | CHLORIDE ION, GLYCEROL, POTASSIUM ION, ... | 著者 | Ramirez, A.S, Boilevin, J, Mehdipour, A.R, Hummer, G, Darbre, T, Reymond, J.L, Locher, K.P. | 登録日 | 2017-09-21 | 公開日 | 2018-02-07 | 最終更新日 | 2018-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nat Commun, 9, 2018
|
|
6S7O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s7o by Molmil](/molmil-images/mine/6s7o) | Cryo-EM structure of human oligosaccharyltransferase complex OST-A | 分子名称: | (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, ... | 著者 | Ramirez, A.S, Kowal, J, Locher, K.P. | 登録日 | 2019-07-05 | 公開日 | 2019-12-18 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Science, 366, 2019
|
|
6EJJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ejj by Molmil](/molmil-images/mine/6ejj) | Structure of a glycosyltransferase / state 2 | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, NerylNeryl pyrophosphate, ... | 著者 | Ramirez, A.S, Boilevin, J, Mehdipour, A.R, Hummer, G, Darbre, T, Reymond, J.L, Locher, K.P. | 登録日 | 2017-09-21 | 公開日 | 2018-02-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase. Nat Commun, 9, 2018
|
|
6FFC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ffc by Molmil](/molmil-images/mine/6ffc) | Structure of an inhibitor-bound ABC transporter | 分子名称: | ATP-binding cassette sub-family G member 2, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Taylor, N.M.I, Bause, M, Bauer, S, Bartholomaeus, R, Stahlberg, H, Bernhardt, G, Koenig, B, Buschauer, A, Altmann, K.H, Locher, K.P. | 登録日 | 2018-01-06 | 公開日 | 2018-04-11 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
|
|
6FEQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6feq by Molmil](/molmil-images/mine/6feq) | Structure of inhibitor-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | 登録日 | 2018-01-03 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
|
|
6SNI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sni by Molmil](/molmil-images/mine/6sni) | Cryo-EM structure of nanodisc reconstituted yeast ALG6 in complex with 6AG9 Fab | 分子名称: | 6AG9-Fab heavy chain, 6AG9-Fab light chain, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Bloch, J.S, Pesciullesi, G, Boilevin, J, Nosol, K, Irobalieva, R.N, Darbre, T, Aebi, M, Kossiakoff, A.A, Reymond, J.L, Locher, K.P. | 登録日 | 2019-08-24 | 公開日 | 2020-03-11 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and mechanism of the ER-based glucosyltransferase ALG6. Nature, 579, 2020
|
|
6ETI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eti by Molmil](/molmil-images/mine/6eti) | Structure of inhibitor-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | 登録日 | 2017-10-26 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
|
|
6FN4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6fn4 by Molmil](/molmil-images/mine/6fn4) | Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Apo form of Human-mouse chimeric ABCB1 (ABCB1HM) in complex with Antigen binding fragment of UIC2., ... | 著者 | Alam, A, Locher, K.P. | 登録日 | 2018-02-02 | 公開日 | 2018-02-21 | 最終更新日 | 2021-06-02 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7ZLG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zlg by Molmil](/molmil-images/mine/7zlg) | Cryo-EM structure of C-mannosyltransferase CeDPY19, in complex with acceptor peptide and bound to CMT2-Fab and anti-Fab nanobody | 分子名称: | Anti-Fab nanobody, C-mannosyltransferase dpy-19, CMT2-Fab heavy chain, ... | 著者 | Bloch, J.S, Mukherjee, S, Mao, R, Irobalieva, R, Kossiakoff, A.A, Goddard-Borger, E.D, Locher, K.P. | 登録日 | 2022-04-15 | 公開日 | 2023-01-11 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase. Nat.Chem.Biol., 19, 2023
|
|