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2BOL
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BU of 2bol by Molmil
CRYSTAL STRUCTURE AND ASSEMBLY OF TSP36, A METAZOAN SMALL HEAT SHOCK PROTEIN
分子名称: SMALL HEAT SHOCK PROTEIN, SULFATE ION
著者Stamler, R.J, Kappe, G, Boelens, W.C, Slingsby, C.
登録日2005-04-12
公開日2005-09-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Wrapping the Alpha-Crystallin Domain Fold in a Chaperone Assembly.
J.Mol.Biol., 353, 2005
2O20
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BU of 2o20 by Molmil
Crystal structure of transcription regulator CcpA of Lactococcus lactis
分子名称: CHLORIDE ION, Catabolite control protein A, SULFATE ION
著者Loll, B, Kowalczyk, M, Alings, C, Chieduch, A, Bardowski, J, Saenger, W, Biesiadka, J.
登録日2006-11-29
公開日2007-03-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the transcription regulator CcpA from Lactococcus lactis
Acta Crystallogr.,Sect.D, 63, 2007
2V2U
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BU of 2v2u by Molmil
Structure of Mouse gammaC-crystallin
分子名称: GAMMA CRYSTALLIN C
著者Purkiss, A.G, Bateman, O.A, Wyatt, K, David, L.L, Wistow, G.J, Slingsby, C.
登録日2007-06-07
公開日2007-06-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Evolutionary Adaptation of Human and Mouse Eye Lens Gammac-Crystallins for Solubility and Stability: Fine-Tuning of Molecular Dipoles.
J.Mol.Biol., 372, 2007
1O9J
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BU of 1o9j by Molmil
The X-ray crystal structure of eta-crystallin
分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ALDEHYDE DEHYDROGENASE, ...
著者Purkiss, A.G, Van Montfort, R, Wistow, G, Slingsby, C.
登録日2002-12-15
公開日2003-04-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Eta-Crystallin: Adaptation of a Class 1 Aldehyde Dehydrogenase for a New Role in the Eye Lens
Biochemistry, 42, 2003
1GME
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BU of 1gme by Molmil
Crystal structure and assembly of an eukaryotic small heat shock protein
分子名称: HEAT SHOCK PROTEIN 16.9B
著者Van Montfort, R.L.M, Basha, E, Friedrich, K.L, Slingsby, C, Vierling, E.
登録日2001-09-13
公開日2001-11-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure and Assembly of an Eukaryotic Small Heat Shock Protein
Nat.Struct.Biol., 8, 2001
1OKI
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BU of 1oki by Molmil
Crystal structure of truncated human beta-B1-crystallin
分子名称: BETA CRYSTALLIN B1
著者van Montfort, R.L.M, Bateman, O.A, Lubsen, N.H, Slingsby, C.
登録日2003-07-25
公開日2004-01-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal Structure of Truncated Human Beta-B1-Crystallin
Protein Sci., 12, 2003
1QEW
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BU of 1qew by Molmil
HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A 0201) COMPLEX WITH A NONAMERIC PEPTIDE FROM MELANOMA-ASSOCIATED ANTIGEN 3 (RESIDUES 271-279)
分子名称: PROTEIN (BETA-2-MICROGLOBULIN), PROTEIN (HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-35 B* 3501 ALPHA CHAIN), ...
著者Orth, P, Alings, C, Saenger, W, Ziegler, A.
登録日1999-04-02
公開日2003-11-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A 0201) COMPLEX WITH A NONAMERIC PEPTIDE FROM MELANOMA-ASSOCIATED ANTIGEN 3 (RESIDUES 271-279)
To be Published
1E7N
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BU of 1e7n by Molmil
The N-terminal domain of beta-B2-crystallin resembles the putative ancestral homodimer
分子名称: BETA-CRYSTALLIN B2
著者Clout, N.J, Basak, A, Wieligmann, K, Bateman, O.A, Jaenicke, R, Slingsby, C.
登録日2000-08-31
公開日2000-10-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The N-Terminal Domain of Betab2-Crystallin Resembles the Putative Ancestral Homodimer.
J.Mol.Biol., 304, 2000
2J9I
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Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re- engineering for a tissue-specific role in the vertebrate eye lens.
分子名称: GLUTAMATE-AMMONIA LIGASE DOMAIN-CONTAINING PROTEIN 1
著者Wyatt, K, White, H.E, Wang, L, Bateman, O.A, Slingsby, C, Orlova, E.V, Wistow, G.
登録日2006-11-09
公開日2006-12-13
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (17 Å)
主引用文献Lengsin is a Survivor of an Ancient Family of Class I Glutamine Synthetases Re-Engineered by Evolution for a Role in the Vertebrate Lens.
Structure, 14, 2006
2IOV
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BU of 2iov by Molmil
Bright-state structure of the reversibly switchable fluorescent protein Dronpa
分子名称: Fluorescent protein Dronpa
著者Stiel, A.C, Trowitzsch, S, Weber, G, Andresen, M, Eggeling, C, Hell, S.W, Jakobs, S, Wahl, M.C.
登録日2006-10-11
公開日2006-12-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献1.8 A bright-state structure of the reversibly switchable fluorescent protein Dronpa guides the generation of fast switching variants
Biochem.J., 402, 2007
1DSL
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GAMMA B CRYSTALLIN C-TERMINAL DOMAIN
分子名称: GAMMA B CRYSTALLIN
著者Norledge, B.V, Mayr, E.-M, Glockshuber, R, Bateman, O.A, Slingsby, C, Jaenicke, R, Driessen, H.P.C.
登録日1996-02-01
公開日1996-07-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins.
Nat.Struct.Biol., 3, 1996
1HA4
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BU of 1ha4 by Molmil
GammaS crystallin C terminal domain from Homo Sapiens
分子名称: GAMMA CRYSTALLIN S
著者Purkiss, A.G, Slingsby, C, Bateman, O.A, Goodfellow, J.M.
登録日2001-03-27
公開日2001-11-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The X-Ray Crystal Structure of Human Gamma S-Crystallin C-Terminal Domain
J.Biol.Chem., 277, 2002
1GAM
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GAMMA B CRYSTALLIN TRUNCATED C-TERMINAL DOMAIN
分子名称: GAMMA B CRYSTALLIN
著者Norledge, B.V, Mayr, E.-M, Glockshuber, R, Bateman, O.A, Slingsby, C, Jaenicke, R, Driessen, H.P.C.
登録日1996-02-02
公開日1996-07-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins.
Nat.Struct.Biol., 3, 1996
1HDF
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BU of 1hdf by Molmil
Evolution of the eye lens beta-gamma-crystallin domain fold
分子名称: CALCIUM ION, SPHERULIN 3A
著者Clout, N.J, Kretschmar, M, Jaenicke, R, Slingsby, C.
登録日2000-11-13
公開日2000-12-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structure of the Calcium-Loaded Spherulin 3A Dimer Sheds Light on the Evolution of the Eye Lens Betagamma-Crystallin Domain Fold
Structure, 9, 2001
1HY0
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BU of 1hy0 by Molmil
CRYSTAL STRUCTURE OF WILD TYPE DUCK DELTA 1 CRYSTALLIN (EYE LENS PROTEIN)
分子名称: DELTA CRYSTALLIN I, SULFATE ION
著者Sampaleanu, L.M, Vallee, F, Slingsby, C, Howell, P.L.
登録日2001-01-17
公開日2001-04-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural studies of duck delta 1 and delta 2 crystallin suggest conformational changes occur during catalysis.
Biochemistry, 40, 2001
6U82
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Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer containing bulge and loop
分子名称: DNA (38-MER), Double homeobox protein 4
著者Shi, K, Aihara, H.
登録日2019-09-04
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD.
Faseb J., 34, 2020
6U81
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Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*CP*CP*CP*AP*TP*TP*AP*CP*GP*C)-3'), ...
著者Shi, K, Aihara, H.
登録日2019-09-04
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD.
Faseb J., 34, 2020
6E99
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BU of 6e99 by Molmil
Crystal structure of Protein Kinase A in complex with the PKI peptide and an amino-pyridinylbenzamide based inhibitor.
分子名称: 2-[(2-aminoethyl)amino]-N-[(1R)-1-(3-methoxyphenyl)ethyl]-4-(pyridin-4-yl)benzamide, PKI peptide, cAMP-dependent protein kinase catalytic subunit alpha
著者Judge, R.A, Hobson, A.D.
登録日2018-07-31
公開日2018-11-14
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
6E9L
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Crystal structure of Protein Kinase A in complex with the PKI peptide and a pyridinylbenzamide based inhibitor
分子名称: N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide, PKI peptide, cAMP-dependent protein kinase catalytic subunit alpha
著者Judge, R.A, Hobson, A.D.
登録日2018-08-01
公開日2018-11-14
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
6E9W
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Crystal structure of Rock1 with a pyridinylbenzamide based inhibitor
分子名称: N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide, Rho-associated protein kinase 1, SULFATE ION
著者Judge, R.A, Hobson, A.D.
登録日2018-08-01
公開日2018-11-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
6ED6
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Crystal structure of Rock2 with a pyridinylbenzamide based inhibitor
分子名称: N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide, Rho-associated protein kinase 2
著者Judge, R.A, Hobson, A.D.
登録日2018-08-08
公開日2018-11-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design.
J. Med. Chem., 61, 2018
4DAY
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Crystal structure of the RMI core complex with MM2 peptide from FANCM
分子名称: Fanconi anemia group M protein, RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2
著者Hoadley, K.A, Keck, J.L.
登録日2012-01-13
公開日2012-03-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome.
Proc.Natl.Acad.Sci.USA, 109, 2012
4E44
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Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer
分子名称: Centromere protein S, Centromere protein X
著者Fox III, D, Zhao, Y, Yang, W, Weidong, W.
登録日2012-03-12
公開日2013-03-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
To be Published
4E45
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Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase hFANCM
分子名称: Centromere protein S, Centromere protein X, Fanconi anemia group M protein, ...
著者Fox III, D, Zhao, Y, Yang, W, Weidong, W.
登録日2012-03-12
公開日2013-03-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
To be Published
6BKY
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Novel Binding Modes of Inhibition of Wild-Type IDH1: Allosteric Inhibition with Cmpd2
分子名称: (2S)-2-hydroxybutanedioic acid, 4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-ONE, Isocitrate dehydrogenase [NADP] cytoplasmic, ...
著者Jakob, C.G, Qiu, W.
登録日2017-11-09
公開日2018-07-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
J. Med. Chem., 61, 2018

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