7DJT
 
 | | Human SARM1 inhibitory state bounded with inhibitor dHNN | | 分子名称: | NAD(+) hydrolase SARM1, O3-methyl O5-(2-methylpropyl) 2,6-dimethyl-4-[2-(oxidanylamino)phenyl]pyridine-3,5-dicarboxylate | | 著者 | Cai, Y, Zhang, H. | | 登録日 | 2020-11-21 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate.
Elife, 10, 2021
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7CRH
 | | Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex | | 分子名称: | (1S)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Yan, W, Shao, Z.H. | | 登録日 | 2020-08-13 | | 公開日 | 2021-03-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
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7CKW
 | | Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex | | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | | 著者 | Yan, W, Shao, W. | | 登録日 | 2020-07-20 | | 公開日 | 2021-03-03 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
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7CKY
 | | Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex | | 分子名称: | 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione, CHOLESTEROL, D(1A) dopamine receptor, ... | | 著者 | Yan, W, Shao, Z. | | 登録日 | 2020-07-20 | | 公開日 | 2021-03-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
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7CKZ
 | | Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex | | 分子名称: | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... | | 著者 | Yan, W, Shao, Z. | | 登録日 | 2020-07-20 | | 公開日 | 2021-03-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
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7CKX
 | | Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex | | 分子名称: | (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | | 著者 | Yan, W, Shao, Z. | | 登録日 | 2020-07-20 | | 公開日 | 2021-03-03 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
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2HU5
 | | Binding of inhibitors by Acylaminoacyl-peptidase | | 分子名称: | Acylamino-acid-releasing enzyme, GLYCEROL, GLYCINE, ... | | 著者 | Kiss, A.L, Hornung, B, Radi, K, Gengeliczki, Z, Sztaray, B, Harmat, V, Polgar, L. | | 登録日 | 2006-07-26 | | 公開日 | 2007-05-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
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2HU7
 | | Binding of inhibitors by Acylaminoacyl peptidase | | 分子名称: | ACETYL GROUP, Acylamino-acid-releasing enzyme, GLYCEROL, ... | | 著者 | Kiss, A.L, Hornung, B, Radi, K, Gengeliczki, Z, Sztaray, B, Harmat, V, Polgar, L. | | 登録日 | 2006-07-26 | | 公開日 | 2007-05-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
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2HU8
 | | Binding of inhibitors by Acylaminoacyl peptidase | | 分子名称: | 2-AMINOBENZOIC ACID, Acylamino-acid-releasing enzyme, GLYCINE, ... | | 著者 | Kiss, A.L, Hornung, B, Radi, K, Gengeliczki, Z, Sztaray, B, Harmat, V, Polgar, L. | | 登録日 | 2006-07-26 | | 公開日 | 2007-05-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Acylaminoacyl Peptidase from Aeropyrum pernix K1 Thought to Be an Exopeptidase Displays Endopeptidase Activity
J.Mol.Biol., 368, 2007
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7F7G
 | | a linear Peptide Inhibitors in complex with GK domain | | 分子名称: | DLG4 GK domain, UNK-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYS-ALA-ILE-GLN-UNK | | 著者 | Shang, Y, Huang, X, Li, X, Zhang, M. | | 登録日 | 2021-06-29 | | 公開日 | 2022-02-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.446 Å) | | 主引用文献 | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
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7F7I
 | | Stapled Peptide Inhibitor in complex with PSD95 GK domain | | 分子名称: | ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2, Disks large homolog 4 | | 著者 | Shang, Y, Huang, X, Li, X, Zhang, M. | | 登録日 | 2021-06-29 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.595 Å) | | 主引用文献 | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
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