8SKQ
 
 | |
3DVL
 | |
8SV4
 | | 7-Deazapurines and 5-Halogenpyrimidine DNA duplex | | 分子名称: | 1,2-ETHANEDIOL, 2-[2-(2-ethoxyethoxy)ethoxy]ethanol, ACETATE ION, ... | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
|
|
8SV3
 | | 7-Deazapurines and 5-Halogenpyrimidine DNA duplex | | 分子名称: | GLYCEROL, MAGNESIUM ION, Modified DNA, ... | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2023-05-15 | | 公開日 | 2023-10-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
|
|
9CIH
 | | Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide across O4-methyl threofuranosyl thymidine in DNA template at extension stage | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), DNA (5'-D(*CP*AP*TP*GP*(A1A0L)P*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-03 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
|
|
8THQ
 | | Nonamer RNA bound to hAgo2-PAZ | | 分子名称: | Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3') | | 著者 | Pallan, P.S, Harp, J.M, Egli, M. | | 登録日 | 2023-07-17 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.
J.Am.Chem.Soc., 2024
|
|
9CHW
 | | Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite threofuranosyl thymidine in DNA template | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(TFT)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-02 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
|
|
9CIQ
 | | Crystal structure of human polymerase eta with incoming threofuranosyl thymine nucleoside triphosphate opposite template dA | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | 著者 | Patra, A, Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-04 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
|
|
9CJ9
 | | Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite O4-methyl threofuranosyl thymidine in DNA template at insertion stage | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(TFT)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-05 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
|
|
9CI9
 | | Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide across threofuranosyl thymidine in DNA template at extension stage | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), DNA (5'-D(*CP*AP*TP*GP*(TFT)P*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Stone, M.P, Egli, M. | | 登録日 | 2024-07-02 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.
Biochemistry, 63, 2024
|
|
168D
 | |
8EVF
 | | HUMAN DNA POLYMERASE ETA EXTENSION COMPLEX WITH AN INCOMING DCTP | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*G)-3'), ... | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2022-10-20 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | | 主引用文献 | The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta.
J.Biol.Chem., 299, 2023
|
|
8EVE
 | | HUMAN DNA POLYMERASE ETA INSERTION COMPLEX | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2022-10-20 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta.
J.Biol.Chem., 299, 2023
|
|
8UB1
 | |
8UAY
 | | Structure of Arginyl-5'-O-adenosine phosphoramidate/RNase A | | 分子名称: | (2S)-2-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}-5-carbamimidamidopentanoic acid (non-preferred name), DI(HYDROXYETHYL)ETHER, Ribonuclease pancreatic | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2023-09-22 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.
Angew.Chem.Int.Ed.Engl., 63, 2024
|
|
8UAZ
 | | Structure of Glutamyl-5'-O-adenosine phosphoramidate/RNase A | | 分子名称: | (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}pentanedioic acid (non-preferred name), DI(HYDROXYETHYL)ETHER, Ribonuclease pancreatic | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2023-09-22 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.
Angew.Chem.Int.Ed.Engl., 63, 2024
|
|
8UAX
 | | Structure of Alanyl-5'-O-adenosine phosphoramidate/RNase A | | 分子名称: | (2S)-2-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}propanoic acid (non-preferred name), DI(HYDROXYETHYL)ETHER, Ribonuclease pancreatic | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2023-09-22 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.
Angew.Chem.Int.Ed.Engl., 63, 2024
|
|
8UB2
 | |
8UB0
 | | Structure of Histidine-5'-O-adenosine phosphoramidate/RNase A | | 分子名称: | (2S)-2-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}-3-(1H-imidazol-4-yl)propanoic acid (non-preferred name), ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2023-09-22 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.
Angew.Chem.Int.Ed.Engl., 63, 2024
|
|
7JJE
 | |
7JJF
 | |
7JY2
 | | Z-DNA joint X-ray/Neutron | | 分子名称: | Chains: A,B | | 著者 | Harp, J.M, Coates, L, Egli, M. | | 登録日 | 2020-08-28 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | NEUTRON DIFFRACTION (1.5 Å), X-RAY DIFFRACTION | | 主引用文献 | Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography.
Nucleic Acids Res., 49, 2021
|
|
7JJD
 | |
8UJT
 | | Crystal structure of human polymerase eta with incoming dAMPnPP nucleotide opposite urea lesion | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(XB9)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Egli, M, Stone, M.P. | | 登録日 | 2023-10-11 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta.
Biochemistry, 63, 2024
|
|
8UJV
 | | Crystal structure of human polymerase eta with incoming dCMPnPP nucleotide opposite urea lesion | | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(UD8)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | 著者 | Tomar, R, Egli, M, Stone, M.P. | | 登録日 | 2023-10-11 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase eta.
Biochemistry, 63, 2024
|
|
