168D

STABILIZING EFFECTS OF THE RNA 2'-SUBSTITUENT: CRYSTAL STRUCTURE OF AN OLIGODEOXYNUCLEOTIDE DUPLEX CONTAINING 2'-O-METHYLATED ADENOSINES

Summary for 168D

• Entry DOI: 10.2210/pdb168d/pdb
• Descriptor: DNA/RNA (5'-D(*GP*CP*GP*TP*)-R(*(A2M)P*)-D(*TP*AP*CP*GP*C)-3') (2 entities in total)
• Functional Keywords: a-dna/rna, double helix, modified, dna-rna hybrid complex, dna-rna hybrid
• Total number of polymer chains: 2
• Total formula weight: 6150.06

Authors

Lubini, P.,Zuercher, W.,Egli, M. (deposition date: 1994-04-08, release date: 1994-08-31, Last modification date: 2024-02-07)

Primary citation

Lubini, P.,Zurcher, W.,Egli, M.
Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.
Chem.Biol., 1:39-45, 1994

PubMed Abstract: The stability of hybrids of 2'-O-methyl-ribonucleotides with complementary RNA is considerably higher than that of the corresponding DNA.RNA duplexes. The 2'-O-modified ribonucleotides are thus an attractive class of compounds for antisense applications. Understanding how these substituents stabilize the structure of the hybrid duplex may be important in the design of ribonucleotides with novel properties.

PubMed: 9383369
DOI: 10.1016/1074-5521(94)90039-6

Experimental method

X-RAY DIFFRACTION (2 Å)