6BBW
 
 | |
4ZOJ
 | |
4ZOF
 | |
6BWH
 | |
4ZOK
 | |
6BWG
 | |
5BO3
 | |
4ZTV
 | | Non-anthranilate-like inhibitor (TAMU-A7) complexed with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis in absence of PRPP | | 分子名称: | 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase | | 著者 | Evans, G.L, Eom, J, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2015-05-15 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis.
To be Published
|
|
5BO2
 | |
5BNE
 | |
3LOG
 | | Crystal structure of MbtI from Mycobacterium tuberculosis | | 分子名称: | CARBONATE ION, GLYCEROL, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ... | | 著者 | Bulloch, E.M.M, Lott, J.S, Baker, E.N, Johnston, J.M. | | 登録日 | 2010-02-03 | | 公開日 | 2011-02-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI).
Chemmedchem, 5, 2010
|
|
1BKA
 | | OXALATE-SUBSTITUTED DIFERRIC LACTOFERRIN | | 分子名称: | FE (III) ION, LACTOFERRIN, OXALATE ION | | 著者 | Baker, H.M, Smith, C.A, Baker, E.N. | | 登録日 | 1996-04-15 | | 公開日 | 1996-11-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Anion binding by transferrins: importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin.
Biochemistry, 35, 1996
|
|
1H5Y
 | | HisF protein from Pyrobaculum aerophilum | | 分子名称: | GLYCEROL, HISF, PHOSPHATE ION | | 著者 | Banfield, M.J, Lott, J.S, McCarthy, A.A, Baker, E.N. | | 登録日 | 2001-05-31 | | 公開日 | 2001-06-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of Hisf, a Histidine Biosynthetic Protein from Pyrobaculum Aerophilum
Acta Crystallogr.,Sect.D, 57, 2001
|
|
1H6A
 | |
1H6B
 | |
2IO6
 | | Wee1 kinase complexed with inhibitor PD330961 | | 分子名称: | 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE, Wee1-like protein kinase | | 著者 | Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. | | 登録日 | 2006-10-10 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.
Eur.J.Med.Chem., 43, 2008
|
|
1H6D
 | |
1H6C
 | |
2IN6
 | | Wee1 kinase complex with inhibitor PD311839 | | 分子名称: | 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID, Wee1-like protein kinase | | 著者 | Squire, C.J, Dickson, J.M, Ivanovic, I, Baker, E.N. | | 登録日 | 2006-10-05 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.
Eur.J.Med.Chem., 43, 2008
|
|
3RMJ
 | | Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis | | 分子名称: | 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J. | | 登録日 | 2011-04-20 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
|
|
1JC5
 | | Crystal Structure of Native Methylmalonyl-CoA Epimerase | | 分子名称: | Methylmalonyl-CoA Epimerase, SULFATE ION | | 著者 | Mc Carthy, A.A, Baker, H.M, Shewry, S.C, Patchett, M.L, Baker, E.N. | | 登録日 | 2001-06-07 | | 公開日 | 2001-07-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold.
Structure, 9, 2001
|
|
1JC4
 | | Crystal Structure of Se-Met Methylmalonyl-CoA Epimerase | | 分子名称: | Methylmalonyl-CoA epimerase, SULFATE ION | | 著者 | Mc Carthy, A.A, Baker, H.M, Shewry, S.C, Patchett, M.L, Baker, E.N. | | 登録日 | 2001-06-07 | | 公開日 | 2001-07-11 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold.
Structure, 9, 2001
|
|
1HXN
 | |
2CEV
 | | ARGINASE FROM BACILLUS CALDEVELOX, NATIVE STRUCTURE AT PH 8.5 | | 分子名称: | GUANIDINE, MANGANESE (II) ION, PROTEIN (ARGINASE) | | 著者 | Bewley, M.C, Jeffrey, P.D, Patchett, M.L, Kanyo, Z.F, Baker, E.N. | | 登録日 | 1999-03-10 | | 公開日 | 1999-04-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily.
Structure Fold.Des., 7, 1999
|
|
2O84
 | | Crystal structure of K206E mutant of N-lobe human transferrin | | 分子名称: | CARBONATE ION, FE (III) ION, POTASSIUM ION, ... | | 著者 | Baker, H.M, Nurizzo, D, Mason, A.B, Baker, E.N. | | 登録日 | 2006-12-12 | | 公開日 | 2007-01-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin.
Acta Crystallogr.,Sect.D, 63, 2007
|
|
