7L8O
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![BU of 7l8o by Molmil](/molmil-images/mine/7l8o) | OXA-48 bound by Compound 4.3 | 分子名称: | 1,2-ETHANEDIOL, 9H-fluorene-2,7-disulfonate, Beta-lactamase, ... | 著者 | Taylor, D.M, Hu, L, Prasad, B.V.V, Palzkill, T. | 登録日 | 2020-12-31 | 公開日 | 2021-12-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. Acs Infect Dis., 7, 2021
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6VKD
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![BU of 6vkd by Molmil](/molmil-images/mine/6vkd) | Crystal Structure of Inhibitor JNJ-36689282 in Complex with Prefusion RSV F Glycoprotein | 分子名称: | 1-cyclopropyl-3-({1-[3-(methylsulfonyl)propyl]-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, CHLORIDE ION, Prefusion RSV F (DS-Cav1), ... | 著者 | McLellan, J.S. | 登録日 | 2020-01-20 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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5FI2
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![BU of 5fi2 by Molmil](/molmil-images/mine/5fi2) | Crystal structure of human GAC in complex with inhibitor UPGL_00009: 2-phenyl-~{N}-[5-[[(3~{R})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol- 2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide | 分子名称: | 2-phenyl-~{N}-[5-[[(3~{R})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | 著者 | Huang, Q, Cerione, R. | 登録日 | 2015-12-22 | 公開日 | 2016-05-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24, 2016
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7DX4
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![BU of 7dx4 by Molmil](/molmil-images/mine/7dx4) | The structure of FC08 Fab-hA.CE2-RBD complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Heavy chain of FC08 Fab, ... | 著者 | Cao, L, Wang, X. | 登録日 | 2021-01-18 | 公開日 | 2021-04-21 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2. Natl Sci Rev, 8, 2021
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3H0I
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5FI7
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![BU of 5fi7 by Molmil](/molmil-images/mine/5fi7) | Crystal structure of human GAC in complex with inhibitor UPGL_00015: 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide | 分子名称: | 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | 著者 | Huang, Q, Cerione, R. | 登録日 | 2015-12-22 | 公開日 | 2016-05-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24, 2016
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8YBQ
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![BU of 8ybq by Molmil](/molmil-images/mine/8ybq) | Choline transporter BetT - CHT bound | 分子名称: | BCCT family transporter, CHOLINE ION | 著者 | Yang, T.J, Nian, Y.W, Lin, H.J, Li, J, Zhang, J.R, Fan, M.R. | 登録日 | 2024-02-16 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Structure and mechanism of the osmoregulated choline transporter BetT. Sci Adv, 10, 2024
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4OHL
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![BU of 4ohl by Molmil](/molmil-images/mine/4ohl) | LEOPARD Syndrome-Associated SHP2/T468M mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | 登録日 | 2014-01-17 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
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4OHH
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![BU of 4ohh by Molmil](/molmil-images/mine/4ohh) | LEOPARD Syndrome-Associated SHP2/Q506P mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | 登録日 | 2014-01-17 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
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6J07
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![BU of 6j07 by Molmil](/molmil-images/mine/6j07) | Crystal structure of human TERB2 and TERB1 | 分子名称: | Telomere repeats-binding bouquet formation protein 1, Telomere repeats-binding bouquet formation protein 2, ZINC ION | 著者 | Wang, Y, Chen, Y, Wu, J, Huang, C, Lei, M. | 登録日 | 2018-12-21 | 公開日 | 2019-02-27 | 実験手法 | X-RAY DIFFRACTION (3.298 Å) | 主引用文献 | The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope. Nat Commun, 10, 2019
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7T6S
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![BU of 7t6s by Molmil](/molmil-images/mine/7t6s) | Structure of the human FPR2-Gi complex with compound C43 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhuang, Y.W. | 登録日 | 2021-12-14 | 公開日 | 2022-03-30 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
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7T6V
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![BU of 7t6v by Molmil](/molmil-images/mine/7t6v) | Structure of the human FPR2-Gi complex with fMLFII | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhuang, Y.W. | 登録日 | 2021-12-14 | 公開日 | 2022-03-30 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
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7T6U
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![BU of 7t6u by Molmil](/molmil-images/mine/7t6u) | Structure of the human FPR2-Gi complex with CGEN-855A | 分子名称: | B9-scFv, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhuang, Y.W. | 登録日 | 2021-12-14 | 公開日 | 2022-03-30 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
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7T6T
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![BU of 7t6t by Molmil](/molmil-images/mine/7t6t) | Structure of the human FPR1-Gi complex with fMLFII | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Zhuang, Y.W. | 登録日 | 2021-12-14 | 公開日 | 2022-03-30 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2. Nat Commun, 13, 2022
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4D8D
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5U5T
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![BU of 5u5t by Molmil](/molmil-images/mine/5u5t) | Crystal structure of EED in complex with H3K27Me3 peptide and 3-(benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide | 分子名称: | (3R)-3-[(2H-1,3-benzodioxol-4-yl)methyl]piperidine-1-carboximidamide, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... | 著者 | Bussiere, D, Shu, W. | 登録日 | 2016-12-07 | 公開日 | 2017-01-11 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60, 2017
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7TCQ
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8IUF
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![BU of 8iuf by Molmil](/molmil-images/mine/8iuf) | Cryo-EM structure of Euglena gracilis super-complex I+III2+IV, composite | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | 著者 | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | 登録日 | 2023-03-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8J9I
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![BU of 8j9i by Molmil](/molmil-images/mine/8j9i) | Cryo-EM structure of Euglena gracilis complex I, turnover state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Wu, M.C, He, Z.X, Tian, H.T, Hu, Y.Q, Han, F.Z, Zhou, L. | 登録日 | 2023-05-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8J9H
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![BU of 8j9h by Molmil](/molmil-images/mine/8j9h) | Cryo-EM structure of Euglena gracilis respiratory complex I, deactive state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | 著者 | Wu, M.C, He, Z.X, Tian, H.T, Hu, Y.Q, Han, F.Z, Zhou, L. | 登録日 | 2023-05-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8J9J
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![BU of 8j9j by Molmil](/molmil-images/mine/8j9j) | Cryo-EM structure of Euglena gracilis complex I, NADH state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Wu, M.C, He, Z.X, Tian, H.T, Hu, Y.Q, Han, F.Z, Zhou, L. | 登録日 | 2023-05-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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8IUJ
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![BU of 8iuj by Molmil](/molmil-images/mine/8iuj) | Cryo-EM structure of Euglena gracilis super-complex III2+IV2, composite | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | 著者 | Wu, M.C, Tian, H.T, He, Z.X, Hu, Y.Q, Zhou, L. | 登録日 | 2023-03-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Euglena's atypical respiratory chain adapts to the discoidal cristae and flexible metabolism. Nat Commun, 15, 2024
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5U5K
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8YBR
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![BU of 8ybr by Molmil](/molmil-images/mine/8ybr) | Choline transporter BetT | 分子名称: | BCCT family transporter | 著者 | Yang, T.J, Nian, Y.W, Lin, H.J, Li, J, Zhang, J.R, Fan, M.R. | 登録日 | 2024-02-16 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | 主引用文献 | Structure and mechanism of the osmoregulated choline transporter BetT. Sci Adv, 10, 2024
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4DJV
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![BU of 4djv by Molmil](/molmil-images/mine/4djv) | Structure of BACE Bound to 2-imino-5-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3-methyl-5-phenylimidazolidin-4-one | 分子名称: | (2E,5R)-2-imino-5-(3'-methoxybiphenyl-3-yl)-3-methyl-5-phenylimidazolidin-4-one, Beta-secretase 1, L(+)-TARTARIC ACID | 著者 | Strickland, C, Cumming, J. | 登録日 | 2012-02-02 | 公開日 | 2012-03-21 | 最終更新日 | 2012-04-04 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor. Bioorg.Med.Chem.Lett., 22, 2012
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