1O0O
| Ribonuclease A in complex with adenosine-2',5'-diphosphate | 分子名称: | ADENOSINE-2'-5'-DIPHOSPHATE, Ribonuclease pancreatic | 著者 | Leonidas, D.D, Oikonomakos, N.G, Chrysina, E.D, Kosmopoulou, M.N, Vlassi, M. | 登録日 | 2003-02-24 | 公開日 | 2003-12-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors PROTEIN SCI., 12, 2003
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2KV0
| 2-Aminopurine incorporation perturbs the dynamics and structure of DNA | 分子名称: | DNA (5'-D(*CP*GP*AP*CP*GP*TP*TP*TP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*AP*(2PR)P*AP*CP*GP*TP*CP*G)-3') | 著者 | Dallmann, A, Dehmel, L, Peters, T, Muegge, C, Griesinger, C.P, Tuma, J, Ernsting, N.P. | 登録日 | 2010-03-03 | 公開日 | 2011-01-19 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | 2-Aminopurine incorporation perturbs the dynamics and structure of DNA. Angew.Chem.Int.Ed.Engl., 49, 2010
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1O6B
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3LS3
| Padron0.9-ON (fluorescent state) | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Padron0.9, ... | 著者 | Brakemann, T, Weber, G, Trowitzsch, S, Wahl, M.C, Jakobs, S. | 登録日 | 2010-02-12 | 公開日 | 2010-03-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Molecular basis of the light-driven switching of the photochromic fluorescent protein Padron. J.Biol.Chem., 285, 2010
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4FZ3
| Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin | 分子名称: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ZINC ION, ... | 著者 | Liu, D, Wu, J, Zhang, D, Chen, K, Jiang, H, Liu, H. | 登録日 | 2012-07-06 | 公開日 | 2013-03-20 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate J.Med.Chem., 56, 2013
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3U6I
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3U6H
| Crystal structure of c-Met in complex with pyrazolone inhibitor 26 | 分子名称: | Hepatocyte growth factor receptor, N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | 著者 | Bellon, S.F, Whittington, D.A, Long, A.L. | 登録日 | 2011-10-12 | 公開日 | 2012-02-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives. J.Med.Chem., 55, 2012
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3ST2
| Dreiklang - equilibrium state | 分子名称: | Dreiklang, PHOSPHATE ION | 著者 | Brakemann, T, Weber, G, Andresen, M, Stiel, A.C, Jakobs, S, Wahl, M.C. | 登録日 | 2011-07-08 | 公開日 | 2011-09-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat.Biotechnol., 29, 2011
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1R3H
| Crystal Structure of T10 | 分子名称: | Beta-2-microglobulin, MHC H2-TL-T10-129 | 著者 | Rudolph, M.G, Wilson, I.A. | 登録日 | 2003-10-02 | 公開日 | 2004-03-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10. Acta Crystallogr.,Sect.D, 60, 2004
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3ST4
| Dreiklang - on state | 分子名称: | Dreiklang, PHOSPHATE ION | 著者 | Brakemann, T, Weber, G, Andresen, M, Stiel, A.C, Jakobs, S, Wahl, M.C. | 登録日 | 2011-07-08 | 公開日 | 2011-09-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat.Biotechnol., 29, 2011
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3FC2
| PLK1 in complex with BI6727 | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Bader, G. | 登録日 | 2008-11-21 | 公開日 | 2009-05-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity. Clin.Cancer Res., 15, 2009
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1IBR
| COMPLEX OF RAN WITH IMPORTIN BETA | 分子名称: | GTP-binding nuclear protein RAN, Importin beta-1 subunit, MAGNESIUM ION, ... | 著者 | Vetter, I.R, Arndt, A, Kutay, U, Goerlich, D, Wittinghofer, A. | 登録日 | 1999-05-14 | 公開日 | 1999-06-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural view of the Ran-Importin beta interaction at 2.3 A resolution Cell(Cambridge,Mass.), 97, 1999
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3ST3
| Dreiklang - off state | 分子名称: | Dreiklang, PHOSPHATE ION | 著者 | Brakemann, T, Weber, G, Andresen, M, Stiel, A.C, Jakobs, S, Wahl, M.C. | 登録日 | 2011-07-08 | 公開日 | 2011-09-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat.Biotechnol., 29, 2011
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1B9Q
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7B5K
| E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain. | 分子名称: | 16S rRNA, 2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid, 23S rRNA, ... | 著者 | Albers, S, Beckert, B, Matthies, M, Schuster, R, Riedner, M, Seuring, C, Sanyal, S, Torda, A, Wilson, N.D, Ignatova, Z. | 登録日 | 2020-12-03 | 公開日 | 2021-05-26 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Harnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities Nat Commun, 2021
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3DNE
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3RJM
| CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c | 分子名称: | Caspase-2, Peptide inhibitor (ACE)VDV(3PX)D-CHO | 著者 | Abendroth, J, Lorimer, D, Stewart, L, Maillard, M, Kiselyov, A.S. | 登録日 | 2011-04-15 | 公開日 | 2011-09-21 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg.Med.Chem., 19, 2011
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1ANR
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3DND
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3GX4
| Crystal Structure Analysis of S. Pombe ATL in complex with DNA | 分子名称: | Alkyltransferase-like protein 1, COBALT HEXAMMINE(III), DNA (5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3'), ... | 著者 | Tubbs, J.L, Arvai, A.S, Tainer, J.A. | 登録日 | 2009-04-01 | 公開日 | 2009-06-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature, 459, 2009
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3GVA
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3GYH
| Crystal Structure Analysis of S. Pombe ATL in complex with damaged DNA containing POB | 分子名称: | 1-PYRIDIN-3-YLBUTAN-1-ONE, Alkyltransferase-like protein 1, DNA (5'-D(*CP*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*G)-3'), ... | 著者 | Tubbs, J.L, Arvai, A.S, Tainer, J.A, Shin, D.S. | 登録日 | 2009-04-03 | 公開日 | 2009-06-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature, 459, 2009
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3H42
| Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody | 分子名称: | Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Piper, D.E, Walker, N.P.C, Romanow, W.G, Thibault, S.T, Tsai, M.M, Yang, E. | 登録日 | 2009-04-17 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc.Natl.Acad.Sci.USA, 106, 2009
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1B9P
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1VGU
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