3FC2

PLK1 in complex with BI6727

Summary for 3FC2

Entry DOI	10.2210/pdb3fc2/pdb
Descriptor	Serine/threonine-protein kinase PLK1, N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywords	protein kinase, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P53350
Total number of polymer chains	1
Total formula weight	38883.58
Authors	Bader, G. (deposition date: 2008-11-21, release date: 2009-05-12, Last modification date: 2023-12-27)
Primary citation	Rudolph, D.,Steegmaier, M.,Hoffmann, M.,Grauert, M.,Baum, A.,Quant, J.,Haslinger, C.,Garin-Chesa, P.,Adolf, G.R. BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity. Clin.Cancer Res., 15:3094-3102, 2009 Cited by PubMed: 19383823 DOI: 10.1158/1078-0432.CCR-08-2445 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation