3FC2
PLK1 in complex with BI6727
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK1 | polymer | 335 | 37634.8 | 1 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (Human) | Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13 |
| 2 | B (A) | N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide | non-polymer | 618.8 | 1 | Chemie (IBI) | |||
| 3 | C, D, F, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | E, I (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | G (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | J (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | K (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | L (A) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 13 - 345 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 11 | - | expression tag |
| Pro 12 | - | expression tag |
| Val 210 | Thr 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37634.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1248.8 | |
| All* | Total formula weight | 38883.6 |
