7GL1
 
 | | Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-8293a91a-8 (Mpro-P1507) | | 分子名称: | (3S)-5-chloro-1'-(6-fluoroisoquinolin-4-yl)-2H-spiro[[1]benzofuran-3,3'-pyrrolidin]-2'-one, 3C-like proteinase, CHLORIDE ION, ... | | 著者 | Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.709 Å) | | 主引用文献 | Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
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7E9B
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7ROV
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2IKO
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2IL2
 | | Crystal Structure of Human Renin Complexed with Inhibitor | | 分子名称: | CITRIC ACID, N-[2-({2-AMINO-6-ETHYL-5-[4-(3-METHOXYPROPYL)-2,2-DIMETHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-YL]PYRIMIDIN-4-YL}AMINO)ETHYL]NAPHTHALENE-2-SULFONAMIDE, Renin | | 著者 | Mochalkin, I. | | 登録日 | 2006-10-02 | | 公開日 | 2006-12-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Anal.Biochem., 360, 2007
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2IKU
 | | Crystal Structure of Human Renin Complexed with Inhibitors | | 分子名称: | 6-ETHYL-5-[(2S)-1-(3-METHOXYPROPYL)-2-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]PYRIMIDINE-2,4-DIAMINE, Renin | | 著者 | Mochalkin, I. | | 登録日 | 2006-10-02 | | 公開日 | 2006-12-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Anal.Biochem., 360, 2007
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6K0R
 | | Ruvbl1-Ruvbl2 with truncated domain II in complex with phosphorylated Cordycepin | | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Zhang, W, Chen, L, Li, W, Ju, D, Huang, N, Zhang, E. | | 登録日 | 2019-05-07 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | | 主引用文献 | Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals.
Sci Transl Med, 12, 2020
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8HPB
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8HQB
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2V37
 | | Solution structure of the N-terminal extracellular domain of human T- cadherin | | 分子名称: | CADHERIN-13 | | 著者 | Dames, S.A, Bang, E.J, Ahrens, T, Haeussinger, D, Grzesiek, S. | | 登録日 | 2007-06-13 | | 公開日 | 2008-06-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Insights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domain.
J. Biol. Chem., 283, 2008
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3EKC
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4YJN
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7DZE
 | | Fabp ground state captured by XFELs | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7DZH
 | | intermediate of FABP with a delay time of 100 ns | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7DZF
 | | Intermediate of FABP with a delay time of 10 ns | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7DZG
 | | Intermediate of FABP with a delay time of 30 ns | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7DZI
 | | intermediate of FABP with a delay time of 300 ns | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7DZJ
 | | Fabp protein before hv | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7DZK
 | | Fabp protein after hv | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7DZL
 | | A69C-M71L mutant of Fabp protein | | 分子名称: | Fatty acid-binding protein, liver, PALMITIC ACID | | 著者 | Li, H, Yu, L.-J, Liu, X, Shen, J.-R, Wang, J. | | 登録日 | 2021-01-25 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.
Nat.Chem., 14, 2022
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7UVF
 | | Crystal structure of ZED8 Fab complex with CD8 alpha | | 分子名称: | CHLORIDE ION, GLYCEROL, Immunoglobulin heavy chain, ... | | 著者 | Yu, C, Davies, C, Koerber, J.T, Williams, S. | | 登録日 | 2022-05-01 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Preclinical development of ZED8, an 89 Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy.
Eur J Nucl Med Mol Imaging, 50, 2023
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8GJI
 | | De novo design of high-affinity protein binders to bioactive helical peptides | | 分子名称: | GCG binder, Glucagon | | 著者 | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | | 登録日 | 2023-03-15 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
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8GJG
 | | De novo design of high-affinity protein binders to bioactive helical peptides | | 分子名称: | gluc_A04_0005, gluc_A04_0005 Binder | | 著者 | Leung, P.J.Y, Bera, A.K, Torres, S.V, Baker, D, Kang, A. | | 登録日 | 2023-03-15 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
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4YK0
 | | Crystal structure of the CBP bromodomain in complex with CPI098 | | 分子名称: | (4R)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, CREB-binding protein | | 著者 | Bellon, S.F, Jayaram, H. | | 登録日 | 2015-03-03 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J.Biol.Chem., 291, 2016
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4YSJ
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