2IKU

Crystal Structure of Human Renin Complexed with Inhibitors

Summary for 2IKU

• Entry DOI: 10.2210/pdb2iku/pdb
• Related: 2IKO 2IL2
• Descriptor: Renin, 6-ETHYL-5-[(2S)-1-(3-METHOXYPROPYL)-2-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]PYRIMIDINE-2,4-DIAMINE (3 entities in total)
• Functional Keywords: renin, inhibitors, drug design, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P00797
• Total number of polymer chains: 2
• Total formula weight: 75369.11

Authors

Mochalkin, I. (deposition date: 2006-10-02, release date: 2006-12-05, Last modification date: 2023-08-30)

• Primary citation: Sarver, R.W.,Peevers, J.,Cody, W.L.,Ciske, F.L.,Dyer, J.,Emerson, S.D.,Hagadorn, J.C.,Holsworth, D.D.,Jalaie, M.,Kaufman, M.,Mastronardi, M.,McConnell, P.,Powell, N.A.,Quin, J.,Van Huis, C.A.,Zhang, E.,Mochalkin, I.; Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.; Anal.Biochem., 360:30-40, 2007; PubMed: 17113558; DOI: 10.1016/j.ab.2006.10.017

Experimental method

X-RAY DIFFRACTION (2.6 Å)