8DGG
| Structure of glycosylated LAG-3 homodimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Silberstein, J.L, Mathews, I.I, Frank, J.A, Chan, K.-W, Fernandez, D, Du, J, Wang, J, Kong, X.-P, Cochran, J.R. | 登録日 | 2022-06-23 | 公開日 | 2022-08-17 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (3.78 Å) | 主引用文献 | Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
2QKW
| Structural basis for activation of plant immunity by bacterial effector protein AvrPto | 分子名称: | Avirulence protein, Protein kinase | 著者 | Xing, W.M, Zou, Y, Liu, Q, Hao, Q, Zhou, J.M, Chai, J.J. | 登録日 | 2007-07-11 | 公開日 | 2007-08-21 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The structural basis for activation of plant immunity by bacterial effector protein AvrPto Nature, 449, 2007
|
|
5GZR
| Zika virus E protein complexed with a neutralizing antibody Z23-Fab | 分子名称: | Z23 Fab heavy chain, Z23 Fab light chain, structural protein E, ... | 著者 | Gao, G.G, Shi, Y, Peng, R, Liu, S. | 登録日 | 2016-10-01 | 公開日 | 2016-11-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (9.4 Å) | 主引用文献 | Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Sci Transl Med, 8, 2016
|
|
4R1D
| The crystal structure of Tle4-Tli4 complex | 分子名称: | CALCIUM ION, Uncharacterized protein | 著者 | Lu, D. | 登録日 | 2014-08-05 | 公開日 | 2014-12-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.749 Å) | 主引用文献 | The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa. Acta Crystallogr.,Sect.D, 70, 2014
|
|
6M1K
| USP7 in complex with a novel inhibitor | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 7, methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-oxidanyl-piperidin-1-yl]methyl]-3-chloranyl-benzoate | 著者 | Liu, S.J, Zhou, X.Y, Li, M.L, Sun, H.B, Wen, X.A. | 登録日 | 2020-02-26 | 公開日 | 2021-03-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.255 Å) | 主引用文献 | N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies. Eur.J.Med.Chem., 199, 2020
|
|
8EX1
| |
8EX0
| |
8EX2
| |
3J1P
| |
3GYP
| Rtt106p | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Histone chaperone RTT106 | 著者 | Liu, Y, Huang, H, Shi, Y, Teng, M. | 登録日 | 2009-04-04 | 公開日 | 2009-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.406 Å) | 主引用文献 | Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010
|
|
3GYO
| Se-Met Rtt106p | 分子名称: | Histone chaperone RTT106 | 著者 | Liu, Y, Huang, H, Shi, Y, Teng, M. | 登録日 | 2009-04-04 | 公開日 | 2009-12-08 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural analysis of Rtt106p reveals a DNA-binding role required for heterochromatin silencing J.Biol.Chem., 285, 2010
|
|
4WX0
| |
4WWZ
| UndA complexed with 2,3-dodecenoic acid | 分子名称: | (2E)-dodec-2-enoic acid, FE (III) ION, OXYGEN MOLECULE, ... | 著者 | Li, X, Cate, J.D.H. | 登録日 | 2014-11-13 | 公開日 | 2014-12-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4WWJ
| UndA, an oxygen-activating, non-heme iron dependent desaturase/decarboxylase | 分子名称: | FE (III) ION, GLYCEROL, SULFATE ION, ... | 著者 | Li, X, Cate, J.D.H. | 登録日 | 2014-11-11 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
6FND
| Crystal structure of Toxoplasma gondii AKMT | 分子名称: | 1,2-ETHANEDIOL, Apical complex lysine methyltransferase, DI(HYDROXYETHYL)ETHER, ... | 著者 | Pivovarova, Y, Dong, G. | 登録日 | 2018-02-02 | 公開日 | 2018-11-14 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Structure of a Novel Dimeric SET Domain Methyltransferase that Regulates Cell Motility. J. Mol. Biol., 430, 2018
|
|
8ELO
| |
8ELQ
| |
8ELP
| |
8WGW
| Local refinement of RBD-ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Wei, X, Zhang, Z. | 登録日 | 2023-09-22 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
|
|
8WGV
| BA.2(S375) Spike (S6P)/hACE2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Wei, X, Zhang, Z. | 登録日 | 2023-09-22 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. Nat.Immunol., 25, 2024
|
|
3H3B
| Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain | 分子名称: | Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 | 著者 | Zhou, H, Liu, Y, Niu, L, Zhu, J, Teng, M. | 登録日 | 2009-04-16 | 公開日 | 2010-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21. J.Biol.Chem., 286, 2011
|
|
1LSL
| Crystal Structure of the Thrombospondin-1 Type 1 Repeats | 分子名称: | Thrombospondin 1, alpha-L-fucopyranose, beta-L-fucopyranose | 著者 | Tan, K, Duquette, M, Liu, J, Dong, Y, Zhang, R, Joachimiak, A, Lawler, J, Wang, J.-H. | 登録日 | 2002-05-17 | 公開日 | 2002-12-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the TSP-1 type 1 repeats: a novel
layered fold and its biological implication. J.Cell Biol., 159, 2002
|
|
6LT0
| cryo-EM structure of C9ORF72-SMCR8-WDR41 | 分子名称: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | 著者 | Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. | 登録日 | 2020-01-21 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7DPV
| SARS-CoV-2 3CL protease (3CLpro) in complex with 7-O-methyl-dihydromyricetin | 分子名称: | (2S,3S)-3,5-dihydroxy-7-methoxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one, 3C-like proteinase | 著者 | Su, H.X, Zhao, W.F, Xie, H, Li, M.J, Xu, Y.C. | 登録日 | 2020-12-21 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nat Commun, 12, 2021
|
|
7DPU
| SARS-CoV-2 3CL protease (3CLpro) in complex with 7-O-methyl-myricetin | 分子名称: | 3C-like proteinase, 7-methoxy-3,5-bis(oxidanyl)-2-[3,4,5-tris(oxidanyl)phenyl]chromen-4-one, GLYCEROL | 著者 | Su, H.X, Zhao, W.F, Xie, H, Li, M.J, Xu, Y.C. | 登録日 | 2020-12-21 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nat Commun, 12, 2021
|
|