8XAI
 
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5Z9R
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7E27
 | | Structure of PfFNT in complex with MMV007839 | | 分子名称: | (Z)-4,4,5,5,5-pentakis(fluoranyl)-1-(4-methoxy-2-oxidanyl-phenyl)-3-oxidanyl-pent-2-en-1-one, Formate-nitrite transporter | | 著者 | Yan, C.Y, Jiang, X, Deng, D, Peng, X, Wang, N, Zhu, A, Xu, H, Li, J. | | 登録日 | 2021-02-04 | | 公開日 | 2021-08-18 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.
Plos Biol., 19, 2021
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7E26
 | | Structure of PfFNT in apo state | | 分子名称: | Formate-nitrite transporter | | 著者 | Yan, C.Y, Jiang, X, Deng, D, Peng, X, Wang, N, Zhu, A, Xu, H, Li, J. | | 登録日 | 2021-02-04 | | 公開日 | 2021-08-18 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.
Plos Biol., 19, 2021
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7E4I
 | | Cryo-EM structure of the yeast mitochondrial SAM-Tom40/Tom5/Tom6 complex at 3.0 angstrom | | 分子名称: | Mitochondrial import receptor subunit TOM40, Mitochondrial import receptor subunit TOM5, Mitochondrial import receptor subunit TOM6, ... | | 著者 | Wang, Q, Guan, Z.Y, Qi, L.B, Yan, C.Y, Yin, P. | | 登録日 | 2021-02-13 | | 公開日 | 2021-09-01 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
Science, 373, 2021
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7E4H
 | | Cryo-EM structure of the yeast mitochondrial SAM-Tom40 complex at 3.0 angstrom | | 分子名称: | Mitochondrial import receptor subunit TOM40, Sorting assembly machinery 35 kDa subunit, Sorting assembly machinery 37 kDa subunit, ... | | 著者 | Wang, Q, Guan, Z.Y, Qi, L.B, Yan, C.Y, Yin, P. | | 登録日 | 2021-02-13 | | 公開日 | 2021-09-01 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
Science, 373, 2021
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3H7V
 | | CRYSTAL STRUCTURE OF O-SUCCINYLBENZOATE SYNTHASE FROM THERMOSYNECHOCOCCUS ELONGATUS BP-1 complexed with MG in the active site | | 分子名称: | MAGNESIUM ION, O-SUCCINYLBENZOATE SYNTHASE | | 著者 | Fedorov, A.A, Fedorov, E.V, Sauder, J.M, Burley, S.K, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2009-04-28 | | 公開日 | 2009-05-12 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family.
Proc.Natl.Acad.Sci.USA, 111, 2014
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8J1X
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8J1W
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7VG2
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7VG3
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6IF2
 | | Complex structure of Rab35 and its effector RUSC2 | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Iporin, MAGNESIUM ION, ... | | 著者 | Lin, L, Zhu, J, Zhang, R. | | 登録日 | 2018-09-18 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.
Structure, 27, 2019
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7YUT
 | | MtaLon-Apo for the spiral oligomers of hexamer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUX
 | | MtaLon-ADP for the spiral oligomers of hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-18 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUU
 | | MtaLon-ADP for the spiral oligomers of trimer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUV
 | | MtaLon-ADP for the spiral oligomers of tetramer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUW
 | | MtaLon-ADP for the spiral oligomers of pentamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-18 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUM
 | | MtaLon-Apo for the spiral oligomers of tetramer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUH
 | | MtaLon-Apo for the spiral oligomers of trimer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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7YUP
 | | MtaLon-Apo for the spiral oligomers of pentamer | | 分子名称: | Lon protease | | 著者 | Li, S, Hsieh, K, Kuo, C, Lee, S, Ho, M, Wang, C, Zhang, K, Chang, C.I. | | 登録日 | 2022-08-17 | | 公開日 | 2023-10-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
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3FUP
 | | Crystal structures of JAK1 and JAK2 inhibitor complexes | | 分子名称: | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Tyrosine-protein kinase JAK2 | | 著者 | Williams, N.K, Bamert, R.S, Patel, O, Fantino, E, Rossjohn, J, Lucet, I.S. | | 登録日 | 2009-01-14 | | 公開日 | 2009-02-10 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.
J.Mol.Biol., 387, 2009
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8GP7
 | | Structure of Trioxacarcin A covalently bound to RET G4-DNA | | 分子名称: | DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), Trioxacarcin A, bound form | | 著者 | Yin, S, Cao, C. | | 登録日 | 2022-08-25 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Trioxacarcin A Interactions with G-Quadruplex DNA Reveal Its Potential New Targets as an Anticancer Agent.
J.Med.Chem., 66, 2023
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7E2W
 | | Crystal structure of isocitrate dehydrogenase from Ostreococcus tauri in complex with isocitrate and magnesium(II) | | 分子名称: | CITRATE ANION, GLYCEROL, ISOCITRIC ACID, ... | | 著者 | Zhu, G.P, Tang, W.G, Wang, P. | | 登録日 | 2021-02-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of NAD + -linked isocitrate dehydrogenase from the green alga Ostreococcus tauri and its evolutionary relationship with eukaryotic NADP + -linked homologs.
Arch.Biochem.Biophys., 708, 2021
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7DNR
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6IF3
 | | Complex structure of Rab35 and its effector ACAP2 | | 分子名称: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Lin, L, Zhu, J, Zhang, R. | | 登録日 | 2018-09-18 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.
Structure, 27, 2019
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