6YNJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ynj by Molmil](/molmil-images/mine/6ynj) | Crystal structure of YTHDC1 with compound DHU_DC1_046 | 分子名称: | (2~{R})-2-(2-chlorophenyl)-5,5-dimethyl-morpholine, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | 登録日 | 2020-04-13 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
|
|
6YNM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ynm by Molmil](/molmil-images/mine/6ynm) | Crystal structure of YTHDC1 with compound DHU_DC1_096 | 分子名称: | 1-[(2~{R},5~{S})-2-(3-chlorophenyl)-5-methyl-morpholin-4-yl]-3-methoxy-propan-2-ol, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A. | 登録日 | 2020-04-14 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure-based design of ligands of the m6A-RNA reader YTHDC1 Eur J Med Chem Rep, 5, 2022
|
|
8OFI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ofi by Molmil](/molmil-images/mine/8ofi) | Ivabradine bound to HCN4 channel | 分子名称: | Ivabradine, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Saponaro, A, Chaves-Sanjuan, A, Sharifzadeh, A.S, Clarke, O.B, Marabelli, C, Bolognesi, M, Thiel, G, Moroni, A. | 登録日 | 2023-03-15 | 公開日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural determinants of ivabradine block of the open pore of HCN4. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
4MND
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mnd by Molmil](/molmil-images/mine/4mnd) | Crystal structure of Archaeoglobus fulgidus IPCT-DIPPS bifunctional membrane protein | 分子名称: | CTP L-myo-inositol-1-phosphate cytidylyltransferase/CDP-L-myo-inositol myo-inositolphosphotransferase, EICOSANE, MAGNESIUM ION | 著者 | Nogly, P, Gushchin, I, Remeeva, A, Esteves, A.M, Ishchenko, A, Ma, P, Grudinin, S, Borges, N, Round, E, Moraes, I, Borshchevskiy, V, Santos, H, Gordeliy, V, Archer, M. | 登録日 | 2013-09-10 | 公開日 | 2014-07-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism. Nat Commun, 5, 2014
|
|
2JTV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jtv by Molmil](/molmil-images/mine/2jtv) | Solution Structure of protein RPA3401, Northeast Structural Genomics Consortium Target RpT7, Ontario Center for Structural Proteomics Target RP3384 | 分子名称: | Protein of Unknown Function | 著者 | Ignatchenko, A, Gutmanas, A, Lemak, A, Yee, A, Karra, M, Srisailam, S, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-08-07 | 公開日 | 2007-10-09 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of protein RPA3401, Northeast Structural Genomics Consortium Target RpT7, Ontario Center for Structural Proteomics Target RP3384 TO BE PUBLISHED
|
|
2WK0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wk0 by Molmil](/molmil-images/mine/2wk0) | Crystal structure of the class A beta-lactamase BS3 inhibited by 6- beta-iodopenicillanate. | 分子名称: | (3S)-2,2-dimethyl-3,4-dihydro-2H-1,4-thiazine-3,6-dicarboxylic acid, BETA-LACTAMASE, CHLORIDE ION, ... | 著者 | Sauvage, E, Zervosen, A, Dive, G, Herman, R, Kerff, F, Amoroso, A, Fonze, E, Pratt, R.F, Luxen, A, Charlier, P. | 登録日 | 2009-06-03 | 公開日 | 2009-12-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural Basis of the Inhibition of Class a Beta-Lactamases and Penicillin-Binding Proteins by 6-Beta-Iodopenicillanate. J.Am.Chem.Soc., 131, 2009
|
|
3ZKM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3zkm by Molmil](/molmil-images/mine/3zkm) | BACE2 FAB COMPLEX | 分子名称: | BETA-SECRETASE 2, DIMETHYL SULFOXIDE, FAB HEAVY CHAIN, ... | 著者 | Banner, D.W, Kuglstatter, A, Benz, J, Stihle, M, Ruf, A. | 登録日 | 2013-01-23 | 公開日 | 2013-05-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones Acta Crystallogr.,Sect.D, 69, 2013
|
|
6YN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yn5 by Molmil](/molmil-images/mine/6yn5) | Inducible lysine decarboxylase LdcI decamer, pH 7.0 | 分子名称: | Inducible lysine decarboxylase | 著者 | Jessop, M, Felix, J, Desfosses, A, Effantin, G, Gutsche, I. | 登録日 | 2020-04-10 | 公開日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Supramolecular assembly of the Escherichia coli LdcI upon acid stress. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
1OND
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ond by Molmil](/molmil-images/mine/1ond) | THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TROLEANDOMYCIN MACROLIDE ANTIBIOTIC | 分子名称: | 23S RIBOSOMAL RNA, 50S ribosomal protein L22, 50S ribosomal protein L32, ... | 著者 | Berisio, R, Schluenzen, F, Harms, J, Bashan, A, Auerbach, T, Baram, D, Yonath, A. | 登録日 | 2003-02-27 | 公開日 | 2003-04-15 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural insight into the role of the ribosomal tunnel in cellular regulation Nat.Struct.Biol., 10, 2003
|
|
6YD9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yd9 by Molmil](/molmil-images/mine/6yd9) | Ecoli GyrB24 with inhibitor 16a | 分子名称: | 1,2-ETHANEDIOL, DNA gyrase subunit B, N-[6-(3-azanylpropanoylamino)-1,3-benzothiazol-2-yl]-3,4-bis(chloranyl)-5-methyl-1H-pyrrole-2-carboxamide | 著者 | Barancokova, M, Skok, Z, Benek, O, Cruz, C.D, Tammela, P, Tomasic, T, Zidar, N, Masic, L.P, Zega, A, Stevenson, C.E.M, Mundy, J, Lawson, D.M, Maxwell, A.M, Kikelj, D, Ilas, J. | 登録日 | 2020-03-20 | 公開日 | 2020-12-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors. Acs Med.Chem.Lett., 11, 2020
|
|
1ORU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1oru by Molmil](/molmil-images/mine/1oru) | Crystal Structure of APC1665, YUAD protein from Bacillus subtilis | 分子名称: | CHLORIDE ION, SULFATE ION, yuaD protein | 著者 | Kim, Y, Joachimiak, A, Edwards, A, Skarina, T, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2003-03-15 | 公開日 | 2003-09-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structure of APC1665, YUAD protein from Bacillus subtilis To be Published
|
|
7QCR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qcr by Molmil](/molmil-images/mine/7qcr) | MLLT4/Afadin PDZ domain in complex with the C-terminal peptide from protein E of SARS-CoV-2 | 分子名称: | Afadin, Envelope small membrane protein, SULFATE ION | 著者 | Zhu, Y, Alvarez, F, Haouz, A, Mechaly, A, Caillet-Saguy, C. | 登録日 | 2021-11-25 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins. Front Microbiol, 13, 2022
|
|
7QCT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qct by Molmil](/molmil-images/mine/7qct) | PDZ2 of LNX2 with SARS-CoV-2_E PBM complex | 分子名称: | Envelope small membrane protein, Ligand of Numb protein X 2 | 著者 | Zhu, Y, Alvarez, F, Haouz, A, Mechaly, A, Caillet-Saguy, C. | 登録日 | 2021-11-25 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.197 Å) | 主引用文献 | Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins. Front Microbiol, 13, 2022
|
|
6YN6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yn6 by Molmil](/molmil-images/mine/6yn6) | Inducible lysine decarboxylase LdcI stacks, pH 5.7 | 分子名称: | Inducible lysine decarboxylase | 著者 | Felix, J, Jessop, M, Desfosses, A, Effantin, G, Gutsche, I. | 登録日 | 2020-04-10 | 公開日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Supramolecular assembly of the Escherichia coli LdcI upon acid stress. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
1OTK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1otk by Molmil](/molmil-images/mine/1otk) | Structural Genomics, Protein paaC | 分子名称: | Phenylacetic acid degradation protein paaC | 著者 | Zhang, R, Joachimiak, A, Edwards, A, Savchenko, A, Skarina, T, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2003-03-21 | 公開日 | 2003-10-14 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The 2 A crystal structure of protein paaC from E. Coli To be Published
|
|
7QCS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qcs by Molmil](/molmil-images/mine/7qcs) | PALS1/MPP5 PDZ domain in complex with SARS-CoV-2_E PBM peptide | 分子名称: | Envelope small membrane protein, Protein PALS1 | 著者 | Zhu, Y, Alvarez, F, Haouz, A, Mechaly, A, Caillet-Saguy, C. | 登録日 | 2021-11-25 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.804 Å) | 主引用文献 | Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins. Front Microbiol, 13, 2022
|
|
1OU0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ou0 by Molmil](/molmil-images/mine/1ou0) | precorrin-8X methylmutase related protein | 分子名称: | precorrin-8X methylmutase related protein | 著者 | Cuff, M.E, Joachimiak, A, Korolev, S, Savchenko, A, Edwards, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2003-03-24 | 公開日 | 2003-10-07 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of a predicted precorrin-8x methylmutase from Thermoplasma acidophilum. Proteins, 58, 2004
|
|
1P8C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1p8c by Molmil](/molmil-images/mine/1p8c) | Crystal structure of TM1620 (APC4843) from Thermotoga maritima | 分子名称: | conserved hypothetical protein | 著者 | Kim, Y, Joachimiak, A, Brunzelle, J.S, Korolev, S.V, Edwards, A, Xu, X, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2003-05-06 | 公開日 | 2003-09-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure Analysis of Thermotoga maritima protein TM1620 (APC4843) To be Published
|
|
6Y4W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y4w by Molmil](/molmil-images/mine/6y4w) | Crystal structure of p38 in complex with SR69 | 分子名称: | 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(cyclohexylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 | 著者 | Chaikuad, A, Roehm, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-23 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
|
|
6Y6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y6h by Molmil](/molmil-images/mine/6y6h) | Crystal structure of STK17b (DRAK2) in complex with UNC-AP-194 probe | 分子名称: | 1,2-ETHANEDIOL, 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Drewry, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-26 | 公開日 | 2020-03-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63, 2020
|
|
7T9Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t9z by Molmil](/molmil-images/mine/7t9z) | |
7TA1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ta1 by Molmil](/molmil-images/mine/7ta1) | Human Ornithine Aminotransferase (hOAT) soaked with gamma-Aminobutyric acid | 分子名称: | 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID, Ornithine aminotransferase, mitochondrial, ... | 著者 | Butrin, A, Wawrzak, Z, Liu, D. | 登録日 | 2021-12-20 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase. J.Biol.Chem., 298, 2022
|
|
6PAJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6paj by Molmil](/molmil-images/mine/6paj) | |
7TA0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ta0 by Molmil](/molmil-images/mine/7ta0) | Human Ornithine Aminotransferase (hOAT) soaked with 5-aminovaleric acid | 分子名称: | 5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid, Ornithine aminotransferase, mitochondrial, ... | 著者 | Butrin, A, Liu, D. | 登録日 | 2021-12-20 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase. J.Biol.Chem., 298, 2022
|
|
6Y6F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y6f by Molmil](/molmil-images/mine/6y6f) | Crystal structure of STK17B (DRAK2) in complex with PKIS43 | 分子名称: | 1,2-ETHANEDIOL, 2-[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Drewry, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-26 | 公開日 | 2020-03-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63, 2020
|
|