2WK0

Crystal structure of the class A beta-lactamase BS3 inhibited by 6- beta-iodopenicillanate.

Summary for 2WK0

• Entry DOI: 10.2210/pdb2wk0/pdb
• Related: 1W7F
• Descriptor: BETA-LACTAMASE, (3S)-2,2-dimethyl-3,4-dihydro-2H-1,4-thiazine-3,6-dicarboxylic acid, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: hydrolase, beta- lactamase, iodopenicillanate, antibiotic resistance, bacillus licheniformis
• Biological source: BACILLUS LICHENIFORMIS
• Total number of polymer chains: 2
• Total formula weight: 60004.46

Authors

Sauvage, E.,Zervosen, A.,Dive, G.,Herman, R.,Kerff, F.,Amoroso, A.,Fonze, E.,Pratt, R.F.,Luxen, A.,Charlier, P. (deposition date: 2009-06-03, release date: 2009-12-01, Last modification date: 2023-12-13)

• Primary citation: Sauvage, E.,Zervosen, A.,Dive, G.,Herman, R.,Amoroso, A.,Joris, B.,Fonze, E.,Pratt, R.F.,Luxen, A.,Charlier, P.,Kerff, F.; Structural Basis of the Inhibition of Class a Beta-Lactamases and Penicillin-Binding Proteins by 6-Beta-Iodopenicillanate.; J.Am.Chem.Soc., 131:15262-, 2009; PubMed: 19919161; DOI: 10.1021/JA9051526

Experimental method

X-RAY DIFFRACTION (1.65 Å)