7SGF
| Lassa virus glycoprotein construct (Josiah GPC-I53-50A) in complex with LAVA01 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Antanasijevic, A, Brouwer, P.J.M, Ward, A.B. | 登録日 | 2021-10-05 | 公開日 | 2022-10-12 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (4.41 Å) | 主引用文献 | Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection. Cell Host Microbe, 30, 2022
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7SIE
| Structure of AAP A-domain (residues 351-605) from Staphylococcus epidermidis | 分子名称: | Accumulation associated protein, CALCIUM ION, CHLORIDE ION | 著者 | Atkin, K.E, Brentnall, A.S, Dodson, E.J, Whelan, F, Clark, L, Turkenburg, J.P, Potts, J.R. | 登録日 | 2021-10-13 | 公開日 | 2022-10-19 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Staphylococcal Periscope proteins Aap, SasG, and Pls project noncanonical legume-like lectin adhesin domains from the bacterial surface. J.Biol.Chem., 299, 2023
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7SGE
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4YYU
| Ficin C crystal form I | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ficin isoform C, SULFATE ION | 著者 | Azarkan, M, Baeyens-Volant, D, Loris, R. | 登録日 | 2015-03-24 | 公開日 | 2016-04-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.177 Å) | 主引用文献 | Crystal structure of four variants of the protease Ficin from the common fig To Be Published
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3GW8
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7SJK
| Structure of PLS A-domain (residues 391-656) from Staphylococcus aureus | 分子名称: | CALCIUM ION, Pls Plasmin sensitive surface protein | 著者 | Clark, L, Whelan, F, Atkin, K.E, Brentnall, A.S, Dodson, E.J, Turkenburg, J.P, Potts, J.R. | 登録日 | 2021-10-18 | 公開日 | 2022-10-26 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.208 Å) | 主引用文献 | Staphylococcal Periscope proteins Aap, SasG, and Pls project noncanonical legume-like lectin adhesin domains from the bacterial surface. J.Biol.Chem., 299, 2023
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4Z16
| Crystal Structure of the Jak3 Kinase Domain Covalently Bound to N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide | 分子名称: | N-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide, Tyrosine-protein kinase JAK3 | 著者 | McNally, R, Tan, L, Gray, N.S, Eck, M.J. | 登録日 | 2015-03-26 | 公開日 | 2016-02-10 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Development of Selective Covalent Janus Kinase 3 Inhibitors. J.Med.Chem., 58, 2015
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7SGD
| Lassa virus glycoprotein construct(Josiah GPCysR4) recovered from GPC-I53-50 nanoparticle by localized reconstruction | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Antanasijevic, A, Brouwer, P.J.M, Ward, A.B. | 登録日 | 2021-10-05 | 公開日 | 2022-10-12 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | 主引用文献 | Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection. Cell Host Microbe, 30, 2022
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3DRP
| HIV reverse transcriptase in complex with inhibitor R8e | 分子名称: | 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile, Reverse transcriptase/ribonuclease H, p51 RT | 著者 | Yan, Y, Prasad, S. | 登録日 | 2008-07-11 | 公開日 | 2008-10-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses. J.Med.Chem., 51, 2008
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3E01
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4YQL
| Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds | 分子名称: | 4-amino-N-[(1S,2R)-2-(4-sulfamoylphenyl)cyclopropyl]-1,2,5-oxadiazole-3-carboxamide, tRNA (guanine-N(1)-)-methyltransferase | 著者 | Elkins, P.A, Bonnette, W.G, Madauss, K.P. | 登録日 | 2015-03-13 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds To Be Published
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4YWF
| AbyA5 | 分子名称: | AbyA5 | 著者 | Byrne, M.J, Race, P.R. | 登録日 | 2015-03-20 | 公開日 | 2016-06-29 | 最終更新日 | 2019-06-19 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis. Angew.Chem.Int.Ed.Engl., 58, 2019
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3GM7
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4XAB
| Crystal Structure of EvdO2 from Micromonospora carbonacea var. aurantiaca | 分子名称: | EvdO2, IMIDAZOLE, NICKEL (II) ION | 著者 | McCulloch, K.M, McCranie, E.K, Sarwar, M, Mathieu, J.L, Gitschlag, B.L, Du, Y, Bachmann, B.O, Iverson, T.M. | 登録日 | 2014-12-13 | 公開日 | 2015-08-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc.Natl.Acad.Sci.USA, 112, 2015
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4XAQ
| mGluR2 ECD and mGluR3 ECD with ligands | 分子名称: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, CHLORIDE ION, Metabotropic glutamate receptor 2, ... | 著者 | Clawson, D.K. | 登録日 | 2014-12-15 | 公開日 | 2015-02-04 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures. J.Med.Chem., 58, 2015
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4XI3
| Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene | 分子名称: | Bazedoxifene, Estrogen receptor | 著者 | Fanning, S.W, Mayne, C.G, Toy, W, Carlson, K, Greene, B, Nowak, J, Walter, R, Panchamukhi, S, Tajhorshid, E, Nettles, K.W, Chandarlapaty, S, Katzenellenbogen, J, Greene, G.L. | 登録日 | 2015-01-06 | 公開日 | 2016-01-13 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.491 Å) | 主引用文献 | The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife, 7, 2018
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4XAA
| Crystal Structure of AviO1 from Streptomyces viridochromogenes Tue57 | 分子名称: | NICKEL (II) ION, Putative oxygenase | 著者 | McCulloch, K.M, McCranie, E.K, Sarwar, M, Mathieu, J.L, Gitschlag, B.L, Du, Y, Bachmann, B.O, Iverson, T.M. | 登録日 | 2014-12-13 | 公開日 | 2015-08-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc.Natl.Acad.Sci.USA, 112, 2015
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4XCB
| Crystal Structure of HygX from Streptomyces hygroscopicus with nickel, 2-oxoglutarate, and hygromycin B bound | 分子名称: | 2-OXOGLUTARIC ACID, HYGROMYCIN B VARIANT, NICKEL (II) ION, ... | 著者 | McCulloch, K.M, McCranie, E.K, Sarwar, M, Mathieu, J.L, Gitschlag, B.L, Du, Y, Bachmann, B.O, Iverson, T.M. | 登録日 | 2014-12-17 | 公開日 | 2015-08-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc.Natl.Acad.Sci.USA, 112, 2015
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3H0Q
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3GN2
| Structure of Pteridine Reductase 1 (PTR1) from TRYPANOSOMA BRUCEI in ternary complex with cofactor (NADP+) and inhibitor (DDD00066730) | 分子名称: | 1-(3,4-dichlorobenzyl)-1H-benzimidazol-2-amine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Tulloch, L.B, Brenk, R, Hunter, W.N. | 登録日 | 2009-03-16 | 公開日 | 2009-12-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening. J.Med.Chem., 52, 2009
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3GOE
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2V59
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4X9W
| PLK-1 polo-box domain in complex with Bioactive Imidazolium-containing phosphopeptide macrocycle 4C | 分子名称: | Macrocyclic phosphopeptide 4C, Serine/threonine-protein kinase PLK1 | 著者 | Grant, R.A, Qian, W.-J, Yaffe, M.B, Burke, T.R. | 登録日 | 2014-12-11 | 公開日 | 2015-07-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers, 104, 2015
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4XAR
| mGluR2 ECD and mGluR3 ECD complex with ligands | 分子名称: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, IODIDE ION, Metabotropic glutamate receptor 3 | 著者 | Clawson, D.K. | 登録日 | 2014-12-15 | 公開日 | 2015-02-11 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures. J.Med.Chem., 58, 2015
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4XBZ
| Crystal Structure of EvdO1 from Micromonospora carbonacea var. aurantiaca | 分子名称: | EvdO1, GLYCEROL, NICKEL (II) ION | 著者 | McCulloch, K.M, McCranie, E.K, Sarwar, M, Mathieu, J.L, Gitschlag, B.L, Du, Y, Bachmann, B.O, Iverson, T.M. | 登録日 | 2014-12-17 | 公開日 | 2015-08-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc.Natl.Acad.Sci.USA, 112, 2015
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