7SGD

Lassa virus glycoprotein construct(Josiah GPCysR4) recovered from GPC-I53-50 nanoparticle by localized reconstruction

Summary for 7SGD

Entry DOI	10.2210/pdb7sgd/pdb
EMDB information	25107 25108 25109
Descriptor	Josiah GPCysR4 I53-50A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	glycoprotein, lassa, josiah, vaccine design, nanoparticle, protein design, viral protein
Biological source	Lassa mammarenavirus More
Total number of polymer chains	6
Total formula weight	458243.61
Authors	Antanasijevic, A.,Brouwer, P.J.M.,Ward, A.B. (deposition date: 2021-10-05, release date: 2022-10-12, Last modification date: 2022-12-28)
Primary citation	Brouwer, P.J.M.,Antanasijevic, A.,Ronk, A.J.,Muller-Krauter, H.,Watanabe, Y.,Claireaux, M.,Perrett, H.R.,Bijl, T.P.L.,Grobben, M.,Umotoy, J.C.,Schriek, A.I.,Burger, J.A.,Tejjani, K.,Lloyd, N.M.,Steijaert, T.H.,van Haaren, M.M.,Sliepen, K.,de Taeye, S.W.,van Gils, M.J.,Crispin, M.,Strecker, T.,Bukreyev, A.,Ward, A.B.,Sanders, R.W. Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection. Cell Host Microbe, 30:1759-, 2022 Cited by PubMed: 36400021 DOI: 10.1016/j.chom.2022.10.018 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.97 Å)

Structure validation