4Z16
Crystal Structure of the Jak3 Kinase Domain Covalently Bound to N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide
Summary for 4Z16
Entry DOI | 10.2210/pdb4z16/pdb |
Descriptor | Tyrosine-protein kinase JAK3, N-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide (3 entities in total) |
Functional Keywords | tyrosine kinase, kinase domain, covalent inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : P52333 |
Total number of polymer chains | 4 |
Total formula weight | 145875.42 |
Authors | McNally, R.,Tan, L.,Gray, N.S.,Eck, M.J. (deposition date: 2015-03-26, release date: 2016-02-10, Last modification date: 2023-11-15) |
Primary citation | Tan, L.,Akahane, K.,McNally, R.,Reyskens, K.M.,Ficarro, S.B.,Liu, S.,Herter-Sprie, G.S.,Koyama, S.,Pattison, M.J.,Labella, K.,Johannessen, L.,Akbay, E.A.,Wong, K.K.,Frank, D.A.,Marto, J.A.,Look, T.A.,Arthur, J.S.,Eck, M.J.,Gray, N.S. Development of Selective Covalent Janus Kinase 3 Inhibitors. J.Med.Chem., 58:6589-6606, 2015 Cited by PubMed: 26258521DOI: 10.1021/acs.jmedchem.5b00710 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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