4Z16
Crystal Structure of the Jak3 Kinase Domain Covalently Bound to N-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Tyrosine-protein kinase JAK3 | polymer | 316 | 35960.8 | 4 | UniProt (P52333) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | A, B, C, D | N-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | non-polymer | 508.0 | 4 | Chemie (4LH) | |||
| 3 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 811 - 1124 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Gly 809 | - | expression tag |
| Ser 810 | - | expression tag |
| Pro 896 | Gln 896 | see remark 999 |
| Glu 897 | Ser 897 | see remark 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143843.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2032.1 | |
| All* | Total formula weight | 145875.4 |
