5UBT
 
 | | CRYSTAL STRUCTURE OF PI3K DELTA IN COMPLEX WITH A 7-(3-(PIPERAZIN-1-YL)PHENYL)PYRROLO[2,1-F][1,2,4] TRIAZIN-4-AMINE DERIVIATINE | | 分子名称: | 1-[4-(3-{4-amino-5-[1-(oxan-4-yl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)piperazin-1-yl]ethan-1-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | | 著者 | Sack, J.S. | | 登録日 | 2016-12-21 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
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5UF7
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5K9I
 | | Crystal structure of c-SRC in complex with a covalent lysine probe | | 分子名称: | 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Wan, X, Ouyang, S, Zhao, Q, Taunton, J. | | 登録日 | 2016-05-31 | | 公開日 | 2017-02-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes.
J. Am. Chem. Soc., 139, 2017
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8HBN
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8H9F
 | | Human ATP synthase state 1 subregion 3 | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, ATP synthase F(0) complex subunit B1, mitochondrial, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-08-30 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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2F9V
 | | HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines | | 分子名称: | (2S,8R,9S,15S)-15-CYCLOHEXYL-9,12-BIS(CYCLOPROPYLMETHYL)-8-HYDROXY-20-METHYL-4,7,11,14,17-PENTAOXO-2-PHENYL-18-OXA-3,6,10,12,13,16-HEXAAZAHENICOSAN-1-OIC ACID, NS3 protease/helicase, ZINC ION, ... | | 著者 | Bogen, S.L, Ruan, S, Liu, R, Agrawal, S, Pichardo, J, Prongay, A, Baroudy, B, Saksena, A, Girijavallabhan, V, Njoroge, F.G. | | 登録日 | 2005-12-06 | | 公開日 | 2007-01-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Depeptidization efforts on P3-P2 a-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity.
Bioorg.Med.Chem.Lett., 16, 2006
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8HFR
 | | NPC-trapped pre-60S particle | | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Li, Z.Q, Chen, S.J, Sui, S.F. | | 登録日 | 2022-11-12 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Nuclear export of pre-60S particles through the nuclear pore complex.
Nature, 618, 2023
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8H9I
 | | Human ATP synthase F1 domain, state2 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase subunit O, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9Q
 | | Human ATP synthase state 3b subregion 3 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase F(0) complex subunit C1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9P
 | | Human ATP synthase F1 domain, state 3b | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase subunit O, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9R
 | | Human ATP synthase state 3b subregion 2 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase subunit d, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9U
 | | Human ATP synthase state 3a (combined) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F(0) complex subunit B1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9V
 | | Human ATP synthase state 3b (combined) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F(0) complex subunit B1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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2F9U
 | | HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane | | 分子名称: | 1,1-DIMETHYLETHYL [1-CYCLOHEXYL-2-[3-[[[1-[2-[[2-[[2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO]-2-OXOETHYL]AMINO]-1,2-DIOXOETHYL]PENTYL]AMINO]CARBONYL]-2-AZABICYCLO[2.2.1]HEPTAN-2-YL]-2-OXOETHYL]CARBAMATE, NS3 protease/helicase', ZINC ION, ... | | 著者 | Venkatraman, S, Njoroge, F.G, Wu, W, Girijavallabhan, V, Prongay, A.J, Butkiewicz, N, Pichardo, J. | | 登録日 | 2005-12-06 | | 公開日 | 2006-06-06 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Novel Inhibitors of Hepatitis C NS3-NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid.
Bioorg.Med.Chem.Lett., 16, 2006
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8H9E
 | | Human ATP synthase F1 domain, state 1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase subunit O, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9S
 | | Human ATP synthase state 1 (combined) | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9N
 | | Human ATP synthase state 3a subregion 2 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase subunit d, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9K
 | | Human ATP synthase state 2 subregion 2 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase subunit d, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9L
 | | Human ATP synthase F1 domain, state 3a | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase subunit O, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9G
 | | Human ATP synthase state 1 subregion 2 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase subunit d, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9J
 | | Human ATP synthase state2 subregion 3 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase F(0) complex subunit C1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9T
 | | Human ATP synthase state 2 (combined) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase F(0) complex subunit B1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8H9M
 | | Human ATP synthase state 3a subregion 3 | | 分子名称: | ATP synthase F(0) complex subunit B1, mitochondrial, ATP synthase F(0) complex subunit C1, ... | | 著者 | Lai, Y, Zhang, Y, Liu, F, Gao, Y, Gong, H, Rao, Z. | | 登録日 | 2022-10-25 | | 公開日 | 2023-05-31 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of the human ATP synthase.
Mol.Cell, 83, 2023
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8ZHQ
 | | SFTSV Gn in complex with JK-8/12 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelopment polyprotein, ... | | 著者 | Shang, H, Guo, Y, Zhang, N, Liu, W, Li, H. | | 登録日 | 2024-05-11 | | 公開日 | 2025-01-08 | | 実験手法 | ELECTRON MICROSCOPY (2.37 Å) | | 主引用文献 | Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome.
Ebiomedicine, 111, 2024
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2OWI
 | | Solution structure of the RGS domain from human RGS18 | | 分子名称: | Regulator of G-protein signaling 18 | | 著者 | Higman, V.A, Leidert, M, Bray, J, Elkins, J, Soundararajan, M, Doyle, D.A, Gileadi, C, Phillips, C, Schoch, G, Yang, X, Brockmann, C, Schmieder, P, Diehl, A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Oschkinat, H, Ball, L.J, Structural Genomics Consortium (SGC) | | 登録日 | 2007-02-16 | | 公開日 | 2007-02-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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