8ZHQ

SFTSV Gn in complex with JK-8/12 Fab

Summary for 8ZHQ

• Entry DOI: 10.2210/pdb8zhq/pdb
• EMDB information: 60112
• Descriptor: JK-12 Fab light chain, JK-8 Fab light chain, JK-8 Fab heavy chain, ... (8 entities in total)
• Functional Keywords: complex, neutralizing antibody, sftsv, viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 130843.87

Authors

Shang, H.,Guo, Y.,Zhang, N.,Liu, W.,Li, H. (deposition date: 2024-05-11, release date: 2025-01-08, Last modification date: 2025-07-23)

Primary citation

Zhang, S.,Shang, H.,Han, S.,Li, J.,Peng, X.,Wu, Y.,Yang, X.,Leng, Y.,Wang, F.,Cui, N.,Xu, L.,Zhang, H.,Guo, Y.,Xu, X.,Zhang, N.,Liu, W.,Li, H.
Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome.
Ebiomedicine, 111:105481-105481, 2024

PubMed Abstract: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phlebovirus that causes viral hemorrhagic fever. Pandemic concerns have arisen due to the increased human-to-human transmission and high mortality rate, highlighting the urgent need for specific therapeutics.

PubMed: 39644769
DOI: 10.1016/j.ebiom.2024.105481

Experimental method

ELECTRON MICROSCOPY (2.37 Å)