8WII
 
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with Obafluorin | | 分子名称: | Threonine--tRNA ligase, ZINC ION, ~{N}-[(2~{R},3~{S})-2-[(4-nitrophenyl)methyl]-4-oxidanylidene-oxetan-3-yl]-2,3-bis(oxidanyl)benzamide | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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3SJJ
 | | RB69 DNA Polymerase Triple Mutant (L561A/S565G/Y567A) Ternary Complex with dUpNpp and a Deoxy-terminated Primer in the presence of Mn2+ | | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3', 5'-D(*TP*CP*AP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', ... | | 著者 | Wang, M, Wang, J, Konigsberg, W.H. | | 登録日 | 2011-06-21 | | 公開日 | 2011-10-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
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8WIJ
 | | Crystal structure of E. coli ThrS catalytic domain mutant L489M in complex with Obafluorin | | 分子名称: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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8WIA
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463S | | 分子名称: | Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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8WIH
 | | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase.
Commun Biol, 7, 2024
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3T9N
 | | Crystal structure of a membrane protein | | 分子名称: | DODECYL-BETA-D-MALTOSIDE, Small-conductance mechanosensitive channel | | 著者 | Yang, M, Zhang, X, Ge, J, Wang, J. | | 登録日 | 2011-08-03 | | 公開日 | 2012-10-31 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.456 Å) | | 主引用文献 | Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
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6JVX
 | | Crystal structure of RBM38 in complex with RNA | | 分子名称: | RNA (5'-R(*UP*GP*UP*GP*UP*GP*UP*GP*UP*GP*UP*G)-3'), RNA-binding protein 38, SULFATE ION | | 著者 | Qian, K, Li, M, Wang, J, Zhang, M, Wang, M. | | 登録日 | 2019-04-17 | | 公開日 | 2020-01-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Structural basis for mRNA recognition by human RBM38.
Biochem.J., 477, 2020
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4DNW
 | | Crystal structure of UVB-resistance protein UVR8 | | 分子名称: | AT5g63860/MGI19_6 | | 著者 | Wu, D, Hu, Q, Yan, Z, Chen, W, Yan, C, Wang, J, Shi, Y. | | 登録日 | 2012-02-09 | | 公開日 | 2012-03-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.773 Å) | | 主引用文献 | Structural basis of ultraviolet-B perception by UVR8.
Nature, 484, 2012
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7JW3
 | | Crystal structure of Aedes aegypti Nibbler NTD domain | | 分子名称: | Exonuclease mut-7 homolog | | 著者 | Xie, W, Sowemimo, I, Hayashi, R, Wang, J, Brennecke, J, Ameres, S.L, Patel, D.J. | | 登録日 | 2020-08-24 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Structure-function analysis of microRNA 3'-end trimming by Nibbler.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2V5Z
 | | Structure of human MAO B in complex with the selective inhibitor safinamide | | 分子名称: | (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE], Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Binda, C, Wang, J, Pisani, L, Caccia, C, Carotti, A, Salvati, P, Edmondson, D.E, Mattevi, A. | | 登録日 | 2007-07-12 | | 公開日 | 2007-10-16 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.
J.Med.Chem., 50, 2007
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5A1Z
 | | Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C | | 分子名称: | ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - LIGHT CHAIN, ENVELOPE PROTEIN, ... | | 著者 | Fibriansah, G, Ibarra, K.D, Ng, T.S, Smith, S.A, Tan, J.L, Lim, X.N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe Jr, J.E, Lok, S.M. | | 登録日 | 2015-05-06 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | | 主引用文献 | Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
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7JW6
 | | Crystal structure of Drosophila Nibbler EXO domain | | 分子名称: | Exonuclease mut-7 homolog | | 著者 | Xie, W, Sowemimo, I, Hayashi, R, Wang, J, Brennecke, J, Ameres, S.L, Patel, D.J. | | 登録日 | 2020-08-24 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure-function analysis of microRNA 3'-end trimming by Nibbler.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5EFI
 | | Crystal structure of mouse CD1d in complex with the p99p lipopeptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | | 著者 | Girardi, E, Wang, J, Zajonc, D.M. | | 登録日 | 2015-10-23 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of an alpha-Helical Peptide and Lipopeptide Bound to the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule CD1d.
J.Biol.Chem., 291, 2016
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5TPQ
 | | E. coli alkaline phosphatase D101A, D153A, R166S, E322A, K328A mutant | | 分子名称: | Alkaline phosphatase, PHOSPHATE ION, ZINC ION | | 著者 | Sunden, F, AlSadhan, I, Lyubimov, A.Y, Doukov, T, Swan, J, Herschlag, D. | | 登録日 | 2016-10-20 | | 公開日 | 2017-11-01 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.
J. Biol. Chem., 292, 2017
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2V60
 | | Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-carboxaldehyde-coumarin | | 分子名称: | 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Binda, C, Wang, J, Pisani, L, Caccia, C, Carotti, A, Salvati, P, Edmondson, D.E, Mattevi, A. | | 登録日 | 2007-07-12 | | 公開日 | 2007-10-16 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50, 2007
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4Y6K
 | | Complex structure of presenilin homologue PSH bound to an inhibitor | | 分子名称: | N-{(2R,4S,5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-leucyl-L-phenylalaninamide, Uncharacterized protein PSH | | 著者 | Dang, S, Wu, S, Wang, J, Shi, Y. | | 登録日 | 2015-02-13 | | 公開日 | 2015-03-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.855 Å) | | 主引用文献 | Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH
Proc.Natl.Acad.Sci.USA, 112, 2015
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2V61
 | | Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin | | 分子名称: | 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Binda, C, Wang, J, Pisani, L, Caccia, C, Carotti, A, Salvati, P, Edmondson, D.E, Mattevi, A. | | 登録日 | 2007-07-13 | | 公開日 | 2007-10-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50, 2007
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4YCW
 | | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... | | 著者 | Fang, P, Wang, J, Guo, M. | | 登録日 | 2015-02-20 | | 公開日 | 2015-06-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor
Chem.Biol., 22, 2015
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6JVY
 | | Crystal structure of RBM38 in complex with single-stranded DNA | | 分子名称: | DNA (5'-D(*TP*GP*TP*GP*TP*GP*TP*GP*TP*GP*TP*G)-3'), RNA-binding protein 38, SULFATE ION | | 著者 | Qian, K, Li, M, Wang, J, Zhang, M, Wang, M. | | 登録日 | 2019-04-17 | | 公開日 | 2020-01-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | | 主引用文献 | Structural basis for mRNA recognition by human RBM38.
Biochem.J., 477, 2020
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4YCU
 | | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase | | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, LYSINE, ... | | 著者 | Fang, P, Wang, J, Guo, M. | | 登録日 | 2015-02-20 | | 公開日 | 2015-06-10 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem. Biol., 22, 2015
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4YCV
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5AX8
 | | Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase | | 分子名称: | Aspartate aminotransferase, mitochondrial | | 著者 | Jiang, X, Wang, J, Chang, H, Zhou, Y. | | 登録日 | 2015-07-20 | | 公開日 | 2016-03-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.989 Å) | | 主引用文献 | Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
Biosci Trends, 10, 2016
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2VRM
 | | Structure of human MAO B in complex with phenyethylhydrazine | | 分子名称: | AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, PHENYLETHANE | | 著者 | Binda, C, Wang, J, Li, M, Hubalek, F, Mattevi, A, Edmondson, D.E. | | 登録日 | 2008-04-09 | | 公開日 | 2008-04-22 | | 最終更新日 | 2014-01-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases a and B
Biochemistry, 47, 2008
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3U83
 | | Crystal structure of nectin-1 | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, Poliovirus receptor-related protein 1 | | 著者 | Zhang, N, Yan, J, Lu, G, Guo, Z, Fan, Z, Wang, J, Shi, Y, Qi, J, Gao, G.F. | | 登録日 | 2011-10-15 | | 公開日 | 2012-03-21 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.499 Å) | | 主引用文献 | Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.
Nat Commun, 2, 2011
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5XOU
 | | Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 7T8 on the guide strand | | 分子名称: | DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*TP*GP*GP*TP*TP*GP*T)-3'), MAGNESIUM ION, ... | | 著者 | Sheng, G, Wang, J, Zhao, H, Wang, Y. | | 登録日 | 2017-05-31 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
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