5A1Z

Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C

Summary for 5A1Z

Entry DOI	10.2210/pdb5a1z/pdb
EMDB information	2996
Descriptor	ENVELOPE PROTEIN, MEMBRANE GLYCOPROTEIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ... (4 entities in total)
Functional Keywords	virus, dengue virus, human antibody, cryo-em, neutralization
Biological source	DENGUE VIRUS 2 More
Cellular location	Host endoplasmic reticulum membrane ; Multi-pass membrane protein : G9FRP5
Total number of polymer chains	12
Total formula weight	264791.42
Authors	Fibriansah, G.,Ibarra, K.D.,Ng, T.S.,Smith, S.A.,Tan, J.L.,Lim, X.N.,Ooi, J.S.G.,Kostyuchenko, V.A.,Wang, J.,de Silva, A.M.,Harris, E.,Crowe Jr, J.E.,Lok, S.M. (deposition date: 2015-05-06, release date: 2015-07-15, Last modification date: 2018-02-07)
Primary citation	Fibriansah, G.,Ibarra, K.D.,Ng, T.S.,Smith, S.A.,Tan, J.L.,Lim, X.N.,Ooi, J.S.,Kostyuchenko, V.A.,Wang, J.,de Silva, A.M.,Harris, E.,Crowe, J.E.,Lok, S.M. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers. Science, 349:88-91, 2015 Cited by PubMed: 26138979 DOI: 10.1126/science.aaa8651 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (6.9 Å)

Structure validation