7SEG
| Crystal structure of the complex of CD16A bound by an anti-CD16A Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Kiefer, J.R, Wallweber, H.A, Polson, A.G. | 登録日 | 2021-09-30 | 公開日 | 2021-11-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.156 Å) | 主引用文献 | A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma. Leukemia, 36, 2022
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7S06
| Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta | 著者 | Li, H, Li, H. | 登録日 | 2021-08-30 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
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7YR6
| Cryo-EM structure of Pseudomonas aeruginosa RsmZ RNA in complex with two RsmA protein dimers | 分子名称: | RsmZ RNA, Translational regulator CsrA | 著者 | Jia, X, Pan, Z, Yuan, Y, Luo, B, Luo, Y, Mukherjee, S, Jia, G, Ling, X, Yang, X, Wu, Y, Liu, T, Wei, X, Bujnick, J.M, Zhao, K, Su, Z. | 登録日 | 2022-08-09 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence. Cell Res., 33, 2023
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5YIM
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7TMD
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7TMB
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7TMG
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5GOG
| Lys29-linked di-ubiquitin | 分子名称: | D-ubiquitin, Ubiquitin | 著者 | Gao, S, Pan, M, Zheng, Y. | 登録日 | 2016-07-27 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.977 Å) | 主引用文献 | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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5YIJ
| Structure of a Legionella effector with substrates | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SdeA, Ubiquitin | 著者 | Feng, Y, Mu, Y, Wang, H. | 登録日 | 2017-10-05 | 公開日 | 2018-05-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature, 557, 2018
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5E4H
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7S05
| Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Li, H, Li, H. | 登録日 | 2021-08-30 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
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5DYJ
| Mysosin heavy chain kinase A catalytic domain mutant - D663A | 分子名称: | ADENOSINE MONOPHOSPHATE, GLYCEROL, Myosin heavy chain kinase A, ... | 著者 | van Staalduinen, L.M, Yang, Y, Jia, Z. | 登録日 | 2015-09-24 | 公開日 | 2016-06-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) alpha-kinase domain apoenzyme reveals a novel autoinhibited conformation. Sci Rep, 6, 2016
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5XOB
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6K0Y
| Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor | 分子名称: | 1,2-ETHANEDIOL, Antibody Heavy Chain, Antibody Light Chain, ... | 著者 | Liu, J.X, Wang, G.Q. | 登録日 | 2019-05-08 | 公開日 | 2019-12-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor. Sci Rep, 9, 2019
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5GO8
| Linear tetra-ubiquitin | 分子名称: | D-ubiquitin, ubiquitin | 著者 | Gao, S, Pan, M, Zheng, Y. | 登録日 | 2016-07-26 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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5GOD
| Lys27-linked di-ubiquitin | 分子名称: | D-ubiquitin, MAGNESIUM ION, Ubiquitin | 著者 | Gao, S, Pan, M, Zheng, Y. | 登録日 | 2016-07-26 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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5GO7
| Linear tri-ubiquitin | 分子名称: | D-ubiquitin, Ubiquitin | 著者 | Gao, S, Pan, M, Zheng, Y. | 登録日 | 2016-07-26 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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5GOC
| Lys11-linked diubiquitin | 分子名称: | D-ubiquitin, SODIUM ION, Ubiquitin | 著者 | Gao, S, Pan, M, Zheng, Y. | 登録日 | 2016-07-26 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.733 Å) | 主引用文献 | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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4F1S
| Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor | 分子名称: | N-(5-{[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]amino}-2-chloropyridin-3-yl)methanesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | 登録日 | 2012-05-07 | 公開日 | 2012-08-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold. Bioorg.Med.Chem.Lett., 22, 2012
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6U9K
| MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153) | 分子名称: | 5'-([(3S)-3-amino-3-carboxypropyl]{[1-(3,3-diphenylpropyl)azetidin-3-yl]methyl}amino)-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ... | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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6U9N
| MLL1 SET N3861I/Q3867L bound to inhibitor 14 (TC-5139) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(4-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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6U9R
| MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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6UBF
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6U9M
| MLL1 SET N3861I/Q3867L bound to inhibitor 16 (TC-5109) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ... | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2019-09-09 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase. Acs Med.Chem.Lett., 11, 2020
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6VG7
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