1G8M
 
 | | CRYSTAL STRUCTURE OF AVIAN ATIC, A BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME IN PURINE BIOSYNTHESIS AT 1.75 ANG. RESOLUTION | | 分子名称: | AICAR TRANSFORMYLASE-IMP CYCLOHYDROLASE, GUANOSINE-5'-MONOPHOSPHATE, POTASSIUM ION | | 著者 | Greasley, S.E, Horton, P, Beardsley, G.P, Benkovic, S.J, Wilson, I.A. | | 登録日 | 2000-11-17 | | 公開日 | 2001-04-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
Nat.Struct.Biol., 8, 2001
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4HJU
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4HJT
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4EW1
 | | High resolution structure of human glycinamide ribonucleotide transformylase in apo form. | | 分子名称: | PHOSPHATE ION, SULFATE ION, Trifunctional purine biosynthetic protein adenosine-3 | | 著者 | Connelly, S, DeMartino, K, Boger, D.L, Wilson, I.A. | | 登録日 | 2012-04-26 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.522 Å) | | 主引用文献 | Biological and Structural Evaluation of 10R- and 10S-Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide Transformylase.
Biochemistry, 52, 2013
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4HLZ
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4EW3
 | | The structure of human glycinamide ribonucleotide transformylase in complex with 10R-methylthio-DDATHF. | | 分子名称: | N-({4-[(1R)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(methylsulfanyl)butyl]phenyl}carbonyl)-L-glutamic acid, PHOSPHATE ION, SULFATE ION, ... | | 著者 | Connelly, S, DeMartino, K, Boger, D.L, Wilson, I.A. | | 登録日 | 2012-04-26 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | | 主引用文献 | Biological and Structural Evaluation of 10R- and 10S-Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide Transformylase.
Biochemistry, 52, 2013
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4F3Z
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4JY4
 | | Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody | | 分子名称: | GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PGT121 heavy chain, ... | | 著者 | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | | 登録日 | 2013-03-29 | | 公開日 | 2013-05-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Plos Pathog., 9, 2013
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4JM2
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4DGV
 | | Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody HCV1, P2(1) form | | 分子名称: | E2 peptide, HCV1 Heavy Chain, HCV1 Light Chain, ... | | 著者 | Kong, L, Wilson, I.A, Law, M. | | 登録日 | 2012-01-26 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.805 Å) | | 主引用文献 | Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4HF5
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4GXV
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4GMS
 | | Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab S139/1 heavy chain, ... | | 著者 | Lee, P.S, Ekiert, D.C, Wilson, I.A. | | 登録日 | 2012-08-16 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4HG4
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4HJS
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4G6A
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4FQK
 | | Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8059 Heavy Chain, ... | | 著者 | Dreyfus, C, Laursen, N.S, Wilson, I.A. | | 登録日 | 2012-06-25 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (5.65 Å) | | 主引用文献 | Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
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4K3H
 | | Immunoglobulin lambda variable domain L5(L89S) fluorogen activationg protein in complex with malachite green | | 分子名称: | 4-{bis[4-(dimethylamino)phenyl]methyl}phenol, GLYCEROL, Immunoglobulin lambda variable domain L5(L89S), ... | | 著者 | Stanfield, R.L, Szent-Gyorgyi, C, Wilson, I.A. | | 登録日 | 2013-04-10 | | 公開日 | 2013-10-09 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Malachite Green Mediates Homodimerization of Antibody VL Domains to Form a Fluorescent Ternary Complex with Singular Symmetric Interfaces.
J.Mol.Biol., 425, 2013
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4FI7
 | | Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide | | 分子名称: | 3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin | | 著者 | Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W. | | 登録日 | 2012-06-08 | | 公開日 | 2013-02-20 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.402 Å) | | 主引用文献 | Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
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4FQM
 | | Structure of B/Brisbane/60/2008 Influenza Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... | | 著者 | Dreyfus, C, Laursen, N.S, Wilson, I.A. | | 登録日 | 2012-06-25 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
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4FQL
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4FQV
 | | Crystal structure of broadly neutralizing antibody CR9114 bound to H7 influenza hemagglutinin | | 分子名称: | Antibody CR9114 heavy chain, Antibody CR9114 light chain, Hemagglutinin HA1, ... | | 著者 | Ekiert, D.C, Dreyfus, C, Wilson, I.A. | | 登録日 | 2012-06-25 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (5.75 Å) | | 主引用文献 | Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
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4FI6
 | | Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide | | 分子名称: | 3-[5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin | | 著者 | Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W. | | 登録日 | 2012-06-08 | | 公開日 | 2013-02-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
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4K3D
 | | Crystal structure of bovine antibody BLV1H12 with ultralong CDR H3 | | 分子名称: | BOVINE ANTIBODY WITH ULTRALONG CDR H3, HEAVY CHAIN, LIGHT CHAIN, ... | | 著者 | Ekiert, D.C, Wang, F, Wilson, I.A. | | 登録日 | 2013-04-10 | | 公開日 | 2013-06-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Reshaping antibody diversity.
Cell(Cambridge,Mass.), 153, 2013
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4JM4
 | | Crystal Structure of PGT 135 Fab | | 分子名称: | PGT 135 Heavy Chain, PGT 135 Light Chain | | 著者 | Kong, L, Wilson, I.A. | | 登録日 | 2013-03-13 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | | 主引用文献 | Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat.Struct.Mol.Biol., 20, 2013
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