3FOC
 
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1X9G
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3HZR
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3HRK
 | | Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidyl-adenylate complex) | | 分子名称: | CHLORIDE ION, HISTIDYL-ADENOSINE MONOPHOSPHATE, Histidyl-tRNA synthetase | | 著者 | Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | | 登録日 | 2009-06-09 | | 公開日 | 2009-12-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
J.Mol.Biol., 397, 2010
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3HRI
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3I7B
 | | Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NM-PP1 | | 分子名称: | 1,2-ETHANEDIOL, 1-(1-methylethyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, ... | | 著者 | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | | 登録日 | 2009-07-08 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.988 Å) | | 主引用文献 | Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Nat.Struct.Mol.Biol., 17, 2010
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3I05
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3HV0
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3I7C
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3IBE
 | | Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma | | 分子名称: | 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | 著者 | Bard, J, Svenson, K. | | 登録日 | 2009-07-15 | | 公開日 | 2009-09-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.798 Å) | | 主引用文献 | ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.
J.Med.Chem., 52, 2009
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1UYA
 | | THE SOLUTION STRUCTURE OF THE A-FORM OF UROGUANYLIN-16 NMR, 10 STRUCTURES | | 分子名称: | UROGUANYLIN-16, ISOMER A | | 著者 | Marx, U.C, Adermann, K, Forssmann, W.-G, Roesch, P. | | 登録日 | 1997-09-11 | | 公開日 | 1998-03-18 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers.
J.Pept.Res., 52, 1998
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1UYB
 | | THE SOLUTION STRUCTURE OF THE B-FORM OF UROGUANYLIN-16 NMR, 10 STRUCTURES | | 分子名称: | UROGUANYLIN-16, ISOMER B | | 著者 | Marx, U.C, Adermann, K, Forssmann, W.-G, Roesch, P. | | 登録日 | 1997-09-11 | | 公開日 | 1998-03-18 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers.
J.Pept.Res., 52, 1998
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1XN4
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3IAL
 | | Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate | | 分子名称: | 5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, GLYCEROL, Prolyl-tRNA synthetase | | 著者 | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | | 登録日 | 2009-07-14 | | 公開日 | 2009-08-11 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr.,Sect.D, 68, 2012
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3I79
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1YZV
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4LYN
 | | Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide | | 分子名称: | (2S)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)-2-phenylpropanamide, Cyclin-dependent kinase 2 | | 著者 | Sack, J.S. | | 登録日 | 2013-07-31 | | 公開日 | 2013-10-02 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities
J.Med.Chem., 45, 2002
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4MFB
 | | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (JLJ555), a non-nucleoside inhibitor | | 分子名称: | 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}indolizine-2-carbonitrile, HIV-1 reverse transcriptase, p51 subunit, ... | | 著者 | Frey, K.M, Anderson, K.S. | | 登録日 | 2013-08-27 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Picomolar Inhibitors of HIV Reverse Transcriptase Featuring Bicyclic Replacement of a Cyanovinylphenyl Group.
J.Am.Chem.Soc., 135, 2013
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3I7F
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3K80
 | | Structure of essential protein from Trypanosoma brucei | | 分子名称: | Antibody, MP18 RNA editing complex protein | | 著者 | Wu, M. | | 登録日 | 2009-10-13 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.
J.Struct.Biol., 174, 2011
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8EGZ
 | | Engineered tyrosine synthase (TmTyrS1) derived from T. maritima TrpB with Ser bound as the amino-acrylate intermediate | | 分子名称: | 1,2-ETHANEDIOL, 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, POTASSIUM ION, ... | | 著者 | Porter, N.J, Almhjell, P.J, Arnold, F.H. | | 登録日 | 2022-09-13 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The beta-subunit of tryptophan synthase is a latent tyrosine synthase.
Nat.Chem.Biol., 2024
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8EH0
 | | Engineered tyrosine synthase (TmTyrS1) derived from T. maritima TrpB with Ser bound as the amino-acrylate intermediate and complexed with quinoline N-oxide | | 分子名称: | 1,2-ETHANEDIOL, 1-oxo-1lambda~5~-quinoline, 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, ... | | 著者 | Porter, N.J, Almhjell, P.J, Arnold, F.H. | | 登録日 | 2022-09-13 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The beta-subunit of tryptophan synthase is a latent tyrosine synthase.
Nat.Chem.Biol., 2024
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8EH1
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8EGY
 | | Engineered holo tyrosine synthase (TmTyrS1) derived from T. maritima TrpB | | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, POTASSIUM ION, ... | | 著者 | Porter, N.J, Almhjell, P.J, Arnold, F.H. | | 登録日 | 2022-09-13 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | The beta-subunit of tryptophan synthase is a latent tyrosine synthase.
Nat.Chem.Biol., 2024
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3TN2
 | | structure analysis of MIP1-beta P8A | | 分子名称: | C-C motif chemokine 4, ZINC ION | | 著者 | Guo, Q, Tang, W.J. | | 登録日 | 2011-09-01 | | 公開日 | 2012-09-05 | | 最終更新日 | 2018-08-22 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
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