8EH1
Engineered tyrosine synthase (TmTyrS1) derived from T. maritima TrpB with Ser bound as the amino-acrylate intermediate and complexed with 4-hydroxyquinoline
Summary for 8EH1
Entry DOI | 10.2210/pdb8eh1/pdb |
Descriptor | Engineered tyrosine synthase (TmTyrS1), 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, quinolin-4-ol, ... (5 entities in total) |
Functional Keywords | tyrosine synthase, engineered enzyme, noncanonical amino acid synthase, biosynthetic protein |
Biological source | Thermotoga maritima |
Total number of polymer chains | 2 |
Total formula weight | 88404.47 |
Authors | Porter, N.J.,Almhjell, P.J.,Arnold, F.H. (deposition date: 2022-09-13, release date: 2023-10-04, Last modification date: 2024-07-03) |
Primary citation | Almhjell, P.J.,Johnston, K.E.,Porter, N.J.,Kennemur, J.L.,Bhethanabotla, V.C.,Ducharme, J.,Arnold, F.H. The beta-subunit of tryptophan synthase is a latent tyrosine synthase. Nat.Chem.Biol., 2024 Cited by PubMed: 38744987DOI: 10.1038/s41589-024-01619-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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