4MI0
| Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) | 分子名称: | Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION | 著者 | Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2013-08-30 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
|
|
6EQC
| Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon | 分子名称: | Hexon protein, scFv of 9C12 antibody | 著者 | Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. | 登録日 | 2017-10-12 | 公開日 | 2018-02-07 | 最終更新日 | 2018-02-14 | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | 主引用文献 | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun, 9, 2018
|
|
5J7F
| Structure of MDM2 with low molecular weight inhibitor with aliphatic linker. | 分子名称: | 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid, E3 ubiquitin-protein ligase Mdm2 | 著者 | Twarda-Clapa, A, Kubica, K, Guzik, K, Dubin, G, Holak, T.A. | 登録日 | 2016-04-06 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J. Med. Chem., 60, 2017
|
|
7ASD
| Structure of native royal jelly filaments | 分子名称: | (3beta,14beta,17alpha)-ergosta-5,24(28)-dien-3-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mattei, S, Ban, A, Picenoni, A, Leibundgut, M, Glockshuber, R, Boehringer, D. | 登録日 | 2020-10-27 | 公開日 | 2020-12-30 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of native glycolipoprotein filaments in honeybee royal jelly. Nat Commun, 11, 2020
|
|
5C5O
| Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S,R)-N-decalin type inhibitor | 分子名称: | (2S)-3-(1H-imidazol-5-yl)-2-({[(3S,4aR,8aS)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal, 3C-like proteinase | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | 登録日 | 2015-06-21 | 公開日 | 2016-06-22 | 最終更新日 | 2020-01-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Fused-ring structure of N-decalin as a novel scaffold for SARS 3CL protease inhibitors to be published
|
|
3VXU
| The complex between T36-5 TCR and HLA-A24 bound to HIV-1 Nef134-10(2F) peptide | 分子名称: | 10-mer peptide from Protein Nef, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | 著者 | Shimizu, A, Fukai, S, Yamagata, A, Iwamoto, A. | 登録日 | 2012-09-20 | 公開日 | 2013-10-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection SCI REP, 3, 2013
|
|
5C9D
| Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii | 分子名称: | ApRick protease, SODIUM ION | 著者 | Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A. | 登録日 | 2015-06-26 | 公開日 | 2015-10-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease Acta Crystallogr.,Sect.D, 71, 2015
|
|
7DIJ
| Falcilysin in complex with MK-4815 | 分子名称: | 1,2-ETHANEDIOL, 2-(aminomethyl)-3,5-ditert-butyl-phenol, ACETATE ION, ... | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | 登録日 | 2020-11-19 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol, 31, 2024
|
|
8BYM
| |
7DIA
| Falcilysin in complex with mefloquine | 分子名称: | (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | 登録日 | 2020-11-18 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol, 31, 2024
|
|
7DI7
| Falcilysin in complex with chloroquine | 分子名称: | ACETATE ION, Falcilysin, N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE, ... | 著者 | Lin, J.Q, El Sahili, A, Lescar, J. | 登録日 | 2020-11-18 | 公開日 | 2021-12-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol, 31, 2024
|
|
8BYT
| |
8BYS
| |
8CIL
| |
8BZ2
| |
5J6S
| Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand | 分子名称: | (2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Saridakis, E, Giastas, P, Mpakali, A, Deprez-Poulain, R, Stratikos, E. | 登録日 | 2016-04-05 | 公開日 | 2017-03-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett, 8, 2017
|
|
7N40
| Crystal structure of LIN9-RbAp48-LIN37, a MuvB subcomplex | 分子名称: | Histone-binding protein RBBP4, Isoform 2 of Protein lin-9 homolog, Protein lin-37 homolog | 著者 | Asthana, A, Ramanan, P, Tripathi, S.M, Rubin, S.M. | 登録日 | 2021-06-02 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes. Nat Commun, 13, 2022
|
|
7NH6
| Crystal structure of human carbonic anhydrase II with 3-(3-((1-(2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4-yl)methyl)ureido)benzenesulfonamide | 分子名称: | 3-(3-((1-(2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4-yl)methyl)ureido)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... | 著者 | Angeli, A, Ferraroni, M. | 登録日 | 2021-02-10 | 公開日 | 2022-02-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. J.Med.Chem., 64, 2021
|
|
3NI8
| Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum | 分子名称: | GLYCEROL, ISOPROPYL ALCOHOL, PFC0360w protein | 著者 | Wernimont, A.K, Hutchinson, A, Sullivan, H, MacKenzie, F, Kozieradzki, I, Cossar, D, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Pizzaro, J.C, Hills, T, Structural Genomics Consortium (SGC) | 登録日 | 2010-06-15 | 公開日 | 2010-08-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum To be Published
|
|
3NIE
| Crystal Structure of PF11_0147 | 分子名称: | MAP2 kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Wernimont, A.K, Hutchinson, A, Sullivan, H, MacKenzie, F, Kozieradzki, I, Chau, I, Lew, J, Senisterra, G, Cossar, D, Amani, M, Artz, J.D, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Hills, T, Structural Genomics Consortium (SGC) | 登録日 | 2010-06-15 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of PF11_0147 To be Published
|
|
3VXM
| The complex between C1-28 TCR and HLA-A24 bound to HIV-1 Nef134-10(2F) peptide | 分子名称: | 10-mer peptide from Protein Nef, Beta-2-microglobulin, C1-28 TCR alpha chain, ... | 著者 | Shimizu, A, Fukai, S, Yamagata, A, Iwamoto, A. | 登録日 | 2012-09-20 | 公開日 | 2013-10-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection SCI REP, 3, 2013
|
|
8CP6
| |
5J94
| Human cathepsin K mutant C25S in complex with the allosteric effector NSC13345 | 分子名称: | 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, Cathepsin K, SULFATE ION | 著者 | Novinec, M, Korenc, M, Lenarcic, B, Baici, A. | 登録日 | 2016-04-08 | 公開日 | 2016-04-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.22002459 Å) | 主引用文献 | A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods. Nat Commun, 5, 2014
|
|
5CMV
| Ultrafast dynamics in myoglobin: dark-state, CO-ligated structure | 分子名称: | CARBON MONOXIDE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Barends, T.R.M, Foucar, L, Ardevol, A, Nass, K.J, Aquila, A, Botha, S, Doak, R.B, Falahati, K, Hartmann, E, Hilpert, M, Heinz, M, Hoffmann, M.C, Koefinger, J, Koglin, J, Kovacsova, G, Liang, M, Milathianaki, D, Lemke, H.T, Reinstein, J, Roome, C.M, Shoeman, R.L, Williams, G.J, Burghardt, I, Hummer, G, Boutet, S, Schlichting, I. | 登録日 | 2015-07-17 | 公開日 | 2015-09-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation. Science, 350, 2015
|
|
5CND
| Ultrafast dynamics in myoglobin: 3 ps time delay | 分子名称: | CARBON MONOXIDE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Barends, T.R.M, Foucar, L, Ardevol, A, Nass, K.J, Aquila, A, Botha, S, Doak, R.B, Falahati, K, Hartmann, E, Hilpert, M, Heinz, M, Hoffmann, M.C, Koefinger, J, Koglin, J, Kovacsova, G, Liang, M, Milathianaki, D, Lemke, H.T, Reinstein, J, Roome, C.M, Shoeman, R.L, Williams, G.J, Burghardt, I, Hummer, G, Boutet, S, Schlichting, I. | 登録日 | 2015-07-17 | 公開日 | 2015-09-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation. Science, 350, 2015
|
|