7YJN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yjn by Molmil](/molmil-images/mine/7yjn) | Cryo-EM structure of the monomeric atSPT-ORM1 (ORM1-N17A) complex | 分子名称: | Long chain base biosynthesis protein 1, Long chain base biosynthesis protein 2a, ORMDL family protein, ... | 著者 | Xie, T, Liu, P, Gong, X. | 登録日 | 2022-07-20 | 公開日 | 2023-04-05 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Sci Adv, 9, 2023
|
|
7YJK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yjk by Molmil](/molmil-images/mine/7yjk) | Cryo-EM structure of the dimeric atSPT-ORM1 complex | 分子名称: | Long chain base biosynthesis protein 1, Long chain base biosynthesis protein 2a, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, ... | 著者 | Xie, T, Liu, P, Gong, X. | 登録日 | 2022-07-20 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Sci Adv, 9, 2023
|
|
7FJO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fjo by Molmil](/molmil-images/mine/7fjo) | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with three T6 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, T6 heavy chain, ... | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | 登録日 | 2021-08-04 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
|
|
7FJN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fjn by Molmil](/molmil-images/mine/7fjn) | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ... | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | 登録日 | 2021-08-04 | 公開日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
|
|
6JWG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jwg by Molmil](/molmil-images/mine/6jwg) | Crystal structure of Formate dehydrogenase mutant C256I/E261P/S381I from Pseudomonas sp. 101 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Formate dehydrogenase, GLYCEROL | 著者 | Feng, Y, Guo, X, Xue, S, Zhao, Z. | 登録日 | 2019-04-20 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.081 Å) | 主引用文献 | Structure-Guided Design of Formate Dehydrogenase for Regeneration of a Non-Natural Redox Cofactor. Chemistry, 26, 2020
|
|
7FJS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7fjs by Molmil](/molmil-images/mine/7fjs) | Crystal structure of T6 Fab bound to theSARS-CoV-2 RBD of B.1.351 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, T6 heavy chain, ... | 著者 | Wang, X, Zhang, L, Zhang, S, Liang, Q. | 登録日 | 2021-08-04 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
|
|
8JNC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jnc by Molmil](/molmil-images/mine/8jnc) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-maltophilin | 分子名称: | (1Z,3E,5S,8R,9S,10S,11R,13R,15R,16S,18Z,24S,25S)-11-ethyl-2,24-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-7,20,27,28-tetraone, Cytochrome P450, FORMIC ACID, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-06 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
5GWV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gwv by Molmil](/molmil-images/mine/5gwv) | Structure of MoeN5-Sso7d fusion protein in complex with a substrate analogue | 分子名称: | (2R)-3-dimethoxyphosphoryloxy-2-[(2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoic acid, MoeN5,DNA-binding protein 7d | 著者 | Ko, T.-P, Guo, R.-T, Chen, C.-C. | 登録日 | 2016-09-14 | 公開日 | 2017-09-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun., 511, 2019
|
|
5GWW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5gww by Molmil](/molmil-images/mine/5gww) | Structure of MoeN5-Sso7d fusion protein in complex with a permethylated substrate analogue | 分子名称: | MoeN5,DNA-binding protein 7d, methyl (2R)-3-dimethoxyphosphoryloxy-2-[(2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoate | 著者 | Ko, T.-P, Guo, R.-T, Chen, C.-C. | 登録日 | 2016-09-14 | 公開日 | 2017-09-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochem. Biophys. Res. Commun., 511, 2019
|
|
8JNP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jnp by Molmil](/molmil-images/mine/8jnp) | Crystal structure of cytochrome P450 CftA from Streptomyces torulosus NRRL B-3889, in complex with the substrate ikarugamycin | 分子名称: | (1Z,3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1(2),3,13,18-tetraene-20,27,28-trione, Cytochrome P450 CftA, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Jiang, P, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-06 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
8JNQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jnq by Molmil](/molmil-images/mine/8jnq) | Crystal structure of cytochrome P450 CftA from Streptomyces torulosus NRRL B-3889, in complex with a substrate compound c | 分子名称: | (1Z,3E,5E,7S,8R,10S,11R,13R,15R,16E,18E,25S)-11-ethyl-2,7-dihydroxy-10-methyl-21,26-diazatetracyclo[23.2.1.09,13.08,15]octacosa-1(2),3,5,16,18-pentaene-20,27,28-trione, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Jiang, P, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-06 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
8JOO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8joo by Molmil](/molmil-images/mine/8joo) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate ikarugamycin | 分子名称: | (1Z,3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1(2),3,13,18-tetraene-20,27,28-trione, Cytochrome P450, FORMIC ACID, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-08 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
8JUA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jua by Molmil](/molmil-images/mine/8jua) | Multifunctional cytochrome P450 enzyme IkaD from Streptomyces sp. ZJ306, in complex with epoxyikarugamycin | 分子名称: | (1Z,3E,5S,7R,8R,10R,11R,12S,13R,15S,16R,17S,19Z,26S)-11-ethyl-2-hydroxy-10-methyl-22,27-diaza-14 oxahexacyclo[24.2.1.05,17.07,16.013,15.08,12]nonacosa-1(2),3,19-triene-21,28,29-trione, Cytochrome P450, FORMIC ACID, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-26 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.00001121 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
8JNO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jno by Molmil](/molmil-images/mine/8jno) | Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-deOH-HSAF | 分子名称: | (1Z,3E,5S,7S,8R,9S,10S,11R,13R,15R,16S,18Z,25S)-11-ethyl-2,7-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-20,27,28-trione, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Zhang, Y.L, Zhang, L.P, Zhang, C.S. | 登録日 | 2023-06-06 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
5I89
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i89 by Molmil](/molmil-images/mine/5i89) | Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02857790 | 分子名称: | (4R)-6-(3-cyclopropyl-1-methyl-1H-indazol-5-yl)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, ACETATE ION, CALCIUM ION, ... | 著者 | Setser, J.W, Poy, F, Bellon, S.F. | 登録日 | 2016-02-18 | 公開日 | 2016-04-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | 主引用文献 | Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett., 7, 2016
|
|
5I83
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i83 by Molmil](/molmil-images/mine/5i83) | Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02773986 | 分子名称: | (4R)-4-methyl-7-[(1R)-1-phenylethoxy]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, CREB-binding protein, THIOCYANATE ION | 著者 | Jayaram, H, Poy, F, Setser, J.W, Bellon, S.F. | 登録日 | 2016-02-18 | 公開日 | 2016-04-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett., 7, 2016
|
|
5I8B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5i8b by Molmil](/molmil-images/mine/5i8b) | CBP in complex with Cpd23 ((R)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one) | 分子名称: | (4R)-6-[3-(benzyloxy)phenyl]-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Murray, J.M. | 登録日 | 2016-02-18 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.5218 Å) | 主引用文献 | Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett., 7, 2016
|
|
7CWQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cwq by Molmil](/molmil-images/mine/7cwq) | Crystal structure of a novel cutinase from Burkhoderiales bacterium RIFCSPLOWO2_02_FULL_57_36 | 分子名称: | DLH domain-containing protein, SULFATE ION | 著者 | Han, X, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | 登録日 | 2020-08-30 | 公開日 | 2021-05-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis. Nat Catal, 4, 2021
|
|
7CUV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cuv by Molmil](/molmil-images/mine/7cuv) | |
7CY0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7cy0 by Molmil](/molmil-images/mine/7cy0) | Crystal structure of S185H mutant PET hydrolase from Ideonella sakaiensis | 分子名称: | ACETIC ACID, Poly(ethylene terephthalate) hydrolase | 著者 | Han, X, Liu, W.D, Zheng, Y.Y, Chen, C.C, Guo, R.T. | 登録日 | 2020-09-03 | 公開日 | 2021-05-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis. Nat Catal, 4, 2021
|
|
4DXA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4dxa by Molmil](/molmil-images/mine/4dxa) | Co-crystal structure of Rap1 in complex with KRIT1 | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Krev interaction trapped protein 1, MAGNESIUM ION, ... | 著者 | Li, X, Zhang, R, Boggon, T.J. | 登録日 | 2012-02-27 | 公開日 | 2012-05-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1). J.Biol.Chem., 287, 2012
|
|
7E30
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7e30 by Molmil](/molmil-images/mine/7e30) | Crystal structure of a novel alpha/beta hydrolase in apo form in complex with citrate | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CITRIC ACID, SULFATE ION, ... | 著者 | Gao, J, Han, X, Zheng, Y.Y, Liu, W.D. | 登録日 | 2021-02-07 | 公開日 | 2022-02-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase. Acs Catalysis, 12, 2022
|
|
7E31
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7e31 by Molmil](/molmil-images/mine/7e31) | Crystal structure of a novel alpha/beta hydrolase mutant in apo form | 分子名称: | TRIETHYLENE GLYCOL, alpha/beta hydrolase | 著者 | Gao, J, Han, X, Zheng, Y.Y, Liu, W.D. | 登録日 | 2021-02-07 | 公開日 | 2022-02-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Multiple Substrate Binding Mode-Guided Engineering of a Thermophilic PET Hydrolase. Acs Catalysis, 12, 2022
|
|
7XY7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xy7 by Molmil](/molmil-images/mine/7xy7) | Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | 登録日 | 2022-05-31 | 公開日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Sci Adv, 8, 2022
|
|
7XY6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xy6 by Molmil](/molmil-images/mine/7xy6) | Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM | 分子名称: | 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | 登録日 | 2022-05-31 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Sci Adv, 8, 2022
|
|