7TTM
| |
7TTX
| |
7TTY
| |
2A4G
| Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound | 分子名称: | ({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]-METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC ACID ISOBUTYL ESTER, NS3 protease/helicase, NS4a peptide, ... | 著者 | Arasappan, A, Njoroge, F.G, Chan, T.Y, Bennett, F, Bogen, S.L, Chen, K, Gu, H, Hong, L, Jao, E, Liu, Y.T, Lovey, R.G, Parekh, T, Pike, R.E, Pinto, P, Santhanam, B, Venkatraman, S, Vaccaro, H, Wang, H, Yang, X, Zhu, Z, Mckittrick, B, Saksena, A.K, Girijavallabhan, V, Pichardo, J, Butkiewicz, N, Ingram, R, Malcolm, B, Prongay, A.J, Yao, N, Marten, B, Madison, V, Kemp, S, Levy, O, Lim-Wilby, M, Tamura, S, Ganguly, A.K. | 登録日 | 2005-06-28 | 公開日 | 2006-07-04 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency. Bioorg.Med.Chem.Lett., 15, 2005
|
|
2A4Q
| HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound. | 分子名称: | (2R)-({N-[(3S)-3-({[(3S,6S)-6-CYCLOHEXYL-5,8-DIOXO-4,7-DIAZABICYCLO[14.3.1]ICOSA-1(20),16,18-TRIEN-3-YL]CARBONYL}AMINO)-2-OXOHEXANOYL]GLYCYL}AMINO)(PHENYL)ACETIC ACID, BETA-MERCAPTOETHANOL, NS3 protease/helicase', ... | 著者 | Chen, K.X, Njoroge, F.G, Prongay, A, Pichardo, J, Madison, V, Girijavallabhan, V. | 登録日 | 2005-06-29 | 公開日 | 2006-07-04 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease Bioorg.Med.Chem.Lett., 15, 2005
|
|
8K4Q
| |
8K79
| |
8K78
| |
7Y8R
| The nucleosome-bound human PBAF complex | 分子名称: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | 著者 | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | 登録日 | 2022-06-24 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of nucleosome-bound human PBAF complex. Nat Commun, 13, 2022
|
|
1C6X
| |
1C6Y
| |
5ZXD
| Crystal structure of ATP-bound human ABCF1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family F member 1 | 著者 | Qu, L, Jiang, Y, Liu, Z.J. | 登録日 | 2018-05-18 | 公開日 | 2018-07-25 | 最終更新日 | 2018-09-19 | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | 主引用文献 | Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins Structure, 26, 2018
|
|
2A4R
| HCV NS3 Protease Domain with a Ketoamide Inhibitor Covalently bound. | 分子名称: | NS3 protease/helicase, Ns4a peptide, ZINC ION, ... | 著者 | Bogen, S, Saksena, A.K, Arasappan, A, Gu, H, Njoroge, F.G, Girijavallabhan, V, Pichardo, J, Butkiewicz, N, Prongay, A, Madison, V. | 登録日 | 2005-06-29 | 公開日 | 2006-07-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Hepatitis C Virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency. Bioorg.Med.Chem.Lett., 15, 2005
|
|
8JFU
| AcrIIA15 in complex with palindromic DNA substrate | 分子名称: | AcrIIA15, DNA (5'-D(*AP*TP*TP*AP*TP*GP*AP*CP*AP*AP*AP*TP*GP*TP*CP*AP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*TP*GP*AP*CP*AP*TP*TP*TP*GP*TP*CP*AP*TP*AP*A)-3') | 著者 | Deng, X, Wang, Y. | 登録日 | 2023-05-18 | 公開日 | 2024-02-28 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | An anti-CRISPR that represses its own transcription while blocking Cas9-target DNA binding. Nat Commun, 15, 2024
|
|
8JFT
| |
8JFO
| |
8JG9
| |
8JFR
| N-terminal domain of AcrIIA15 in complex with palindromic DNA substrate | 分子名称: | AcrIIA15, DNA (5'-D(*AP*TP*TP*AP*TP*GP*AP*CP*AP*AP*AP*TP*GP*TP*CP*AP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*TP*GP*AP*CP*AP*TP*TP*TP*GP*TP*CP*AP*TP*AP*A)-3') | 著者 | Deng, X, Wang, Y. | 登録日 | 2023-05-18 | 公開日 | 2024-02-28 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | An anti-CRISPR that represses its own transcription while blocking Cas9-target DNA binding. Nat Commun, 15, 2024
|
|
7XSW
| Structure of SARS-CoV-2 antibody S309 with GX/P2V/2017 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, S309 Heavy Chain, S309 Lambda Chain, ... | 著者 | Jia, Y.F, Chai, Y, Wang, Q.H, Gao, G.F. | 登録日 | 2022-05-15 | 公開日 | 2023-01-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Cross-reaction of current available SARS-CoV-2 MAbs against the pangolin-origin coronavirus GX/P2V/2017. Cell Rep, 41, 2022
|
|
8GTP
| cryo-EM structure of Omicron BA.5 S protein in complex with XGv289 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, X.Y, Zhang, Y.Y, Chi, X.M, Huang, B.D, Wu, L.S, Zhou, Q. | 登録日 | 2022-09-08 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants. Cell Discov, 9, 2023
|
|
8GTO
| cryo-EM structure of Omicron BA.5 S protein in complex with XGv282 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, X.Y, Zhang, Y.Y, Chi, X.M, Huang, B.D, Wu, L.S, Zhou, Q. | 登録日 | 2022-09-08 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants. Cell Discov, 9, 2023
|
|
8GTQ
| cryo-EM structure of Omicron BA.5 S protein in complex with S2L20 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xia, X.Y, Zhang, Y.Y, Chi, X.M, Huang, B.D, Wu, L.S, Zhou, Q. | 登録日 | 2022-09-08 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants. Cell Discov, 9, 2023
|
|
7YOJ
| Structure of CasPi with guide RNA and target DNA | 分子名称: | CasPi, DNA (30-MER), DNA (5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*CP*CP*AP*G)-3'), ... | 著者 | Li, C.P, Wang, J, Liu, J.J. | 登録日 | 2022-08-01 | 公開日 | 2023-02-15 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | The compact Cas pi (Cas12l) 'bracelet' provides a unique structural platform for DNA manipulation. Cell Res., 33, 2023
|
|
8T1X
| |
8XC4
| Nipah virus attachment glycoprotein head domain in complex with a broadly neutralizing antibody 1E5 | 分子名称: | 1E5-VH, 1E5-VL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, P.F, Yu, C.M, Chen, W. | 登録日 | 2023-12-08 | 公開日 | 2024-01-24 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer. Nat Commun, 15, 2024
|
|